Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RRAGAP1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:44888573-44889043  UCSC
Coordinates (T2T) chr14:39080532-39081002  UCSC
Coordinates (hg19) chr14:45357776-45358246  UCSC
Strand -
Parental Sequence NM_006064.5
Parental seq. overlap 384 bp
Parental seq. overlap (%) 18.7%
Genomic Region Intergenic
Retrocopy Summary RRAGAP1, located on chr14:44888573-44889043, is a retrocopy of the parental gene RRAGB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RRAGB
Full Name Ras related GTP binding B
Also known as RAGB|bA465E19.1
Coordinate chrX:55717747-55758774
Strand +
Gene summary Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RRAGBP2
Bonobo Pan paniscus RRAGBP2
Gorilla Gorilla gorilla RRAGBP2
Orangutan Pongo abelii RRAGBP2
Gibbon Nomascus leucogenys RRAGBP1
Green monkey Chlorocebus sabaeus RRAGBP2
Crab-eating macaque Macaca fascicularis RRAGBP1
Rhesus Macaca mulatta RRAGBP1
Baboon Papio anubis RRAGBP1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104656747P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RRAGAP1
GTTTGTCTCACCCACTAGAGTGTGCTTATTTGCAAACATCCACCTGGGATGAAAAGCGCTACAAAGCCTGGTCCAGTATTGCTTATCAGCTGATTCCCAATGTTCAGCAACTGAAGATGAACACAAGGAATTTTGCCCGAATTCTTGAAGTCGATGAAGTTCTACTGTTTGAAAGAGCTACATTCTTGGTTATTTCCCATTACCAGTGCAAAGAGCATCACGATGGCCACAGATTTGAGAAGATCAGCAACATTATTAAGCAGTTCAGCTGAGCTGCAATAAATTGGTCCCTTCTTTCCGGAGTATGGAAGTTATGAATTCTAACTTCACCTCATTCATTGACATCTTCACATCAAACATCTAGGTGACGGTTGTTACGTCAGATCCGTAGATGCCTTCTGTAGCTACTCTGATCAACAGTCGAAAAACCAGGAAACACTGAAAATCTGGAGAATGGATGGCCCCAAGCAC
>NM_006064.5
AGATGCCCACGTGATCCTGGCCTGCAGTTGGGTGGCTGCGGTGAGATACCTGGGTTCCTGAAGGGCGGGTGGTTAGGTCGTAACTACTGCCCCCGCCGGCTGACTCTCCGAGCGGCCGGGCTCGGAAGCCACGAGCCAGCTGAGGCGTTCTCCGCTTAGTGCCTACGGCATGGGTCAGCTCTTTCTGCCACCTCCGCCTTCGCGGTCCTCACCTCTTTGCGGGTGAAGTTACCTTTGGGTTTCCAGACCTTGGGGGCCTGAGGCCCAAACTCGGGACGAACCCCTAACCCACCTCTCTTTTCCTGTCATTCTCCAACTCTTACTTTGTACCACGGAATCACTTGGCCTTAAAGCTAGCCAGCTCGGCCGTGCCTTGAGGCCAGGTTCGAGAGATAAAGGTAACCGTGGGGAAAGCGGCCCCCCAGTGGACAAAGGCGGAGGCAAGAATAGAGCAGGCCTGAGGGCCATAGGCGATGAGAATAGGCAGTTGAGGGGTGAAAAAGAaaacaaacaaacaacaacaacaaacCCTGAAGAGTACTGAAGATTTAGAAGGGACTGGAAAGGACTTGTTGCGCAATGGAAGAATCTGACTCTGAGAAAACGACGGAGAAAGAAAATCTGGGGCCGAGAATGGATCCACCACTAGGGGAACCGGAAGGATCGCTTGGGTGGGTGCTACCAAATACAGCCATGAAGAAAAAGGTGCTGTTGATGGGTAAAAGTGGGTCTGGTAAGACCAGCATGAGGTCTATTATCTTTGCAAATTATATTGCCAGAGACACACGTCGCCTTGGCGCAACAATTGATGTAGAACATTCTCATGTTCGATTTCTGGGAAACCTGGTATTGAACCTGTGGGATTGTGGTGGGCAAGACACCTTCATGGAAAATTATTTCACTAGCCAACGGGACAACATCTTCCGAAATGTGGAGGTTCTGATTTATGTCTTTGATGTGGAGAGCCGCGAACTGGAAAAGGACATGCACTATTACCAATCATGCCTGGAGGCCATTCTGCAGAATTCTCCAGATGCCAAAATATTTTGCTTGGTACACAAAATGGATCTGGTACAGGAGGATCAACGGGACCTGATTTTTAAAGAGCGAGAAGAAGATTTGAGGCGTTTGTCTCGCCCATTGGAATGTTCTTGTTTCCGAACATCTATCTGGGATGAAACCCTCTATAAGGCTTGGTCCAGCATAGTTTATCAGCTGATTCCCAATGTTCAGCAGCTGGAAATGAACCTAAGGAATTTTGCTGAAATTATCGAAGCTGATGAAGTACTTCTTTTTGAGAGAGCTACTTTTCTGGTAATTTCTCACTATCAGTGTAAAGAGCAGCGTGATGCCCATAGATTTGAGAAAATAAGCAACATTATTAAGCAGTTCAAGCTGAGCTGCAGCAAGCTGGCTGCCTCTTTCCAGAGTATGGAAGTCAGGAACTCTAACTTCGCTGCTTTCATTGACATCTTTACATCCAACACTTATGTGATGGTTGTGATGTCTGATCCGTCCATTCCTTCTGCAGCTACTCTGATCAACATCCGCAATGCCAGGAAACACTTTGAAAAGCTGGAAAGAGTGGATGGACCAAAGCAGTGTCTTCTCATGCGCTAAACATTGATGAATATTGTTTCACACAAAAATTAAAAGTTTCCTAATTAATGTTGTATTCATATATGTAGGCTCTGAAATGTTGTGATGCTTATTGCTTCTGTATTTCTTCTCTACTCCCTAGTCTTAATGTTTAACCTTGAATGCTATTAACTTAAATAGCCATTGAGGAGTTAGAAGATGAATTGTTCATGAAGTCGGTGTTACATAAAAGTAGGTGATATGTAAGTTTTCTGATAACAAGGTTCTAATAGTGTTTAAATGTACTGGTAACCTGGTTCCAATAGTTGTGTTTGCCCAAGCCTTTCTCGGCATCATCTTGTATTCCTTATCAGATAGTAAGTAACCTGTAAGTTTGGAGTATTACTGTTTTCTCAGCATGCATTAAAAATATTCCTTAACTTCAATTGTAAATAAACTTTTGGTGTTAGGGA

Publications

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