Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FDPSP3
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:54884855-54886223  UCSC
Coordinates (T2T) chr14:49090053-49091421  UCSC
Coordinates (hg19) chr14:55351573-55352941  UCSC
Strand -
Parental Sequence NM_001135822.2
Parental seq. overlap 686 bp
Parental seq. overlap (%) 46.4%
Genomic Region Intragenic (GCH1)
Retrocopy Summary FDPSP3, located on chr14:54884855-54886223, is a retrocopy of the parental gene FDPS. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FDPS
Full Name farnesyl diphosphate synthase
Also known as FPPS|FPS|POROK9
Coordinate chr1:155308801-155320665
Strand +
Gene summary This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FDPSP6
Bonobo Pan paniscus FDPSP4
Gorilla Gorilla gorilla FDPSP4
Orangutan Pongo abelii FDPSP5
Gibbon Nomascus leucogenys FDPSP1
Green monkey Chlorocebus sabaeus FDPSP2
Crab-eating macaque Macaca fascicularis FDPSP7
Rhesus Macaca mulatta FDPSP4
Baboon Papio anubis FDPSP4
Golden snub-nosed monkey Rhinopithecus roxellana FDPSP2
Marmoset Callithrix jacchus FDPSP24
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FDPSP3
TTGTGCTGCAAGCTTTCTTCCTGGTGGCAGATGACATCAGGGATTCATCCCTCACCTTGCTGGGGGCAGATCTGCTTGTATCAGAAGCCAGGTGTAGGTTTGGATGCCATCAATGATGCTATGCTTCTAGAAGCATCTATCTATCACCTGTTGAAGCTCTGTTGCTGAGAGCAACCCCATTACCTGAACCTGAAAAAGCACTTCCTGTGGAGTTCCTATTAGACAGAGATCAGGCAGACCCTGGACCCCATCACAGCCCCCCAGAGCAATGTGGATCTTGACTGGTTCACTGAAAAGAGGTACAAATCACTGTCAAGTATAAGACAGCTTTCTACTTCTTCTACCATCCTGAAGCTGCAGCCATGTCTATGGCAGGCGTCAGTGTGGGGAAGGAATGGGCCAATGACAGGAAGATCCTGCTGGAGTTAGGAGTTCTTTCAGATTCAGGATGATTACCTTGACCTCTTTGGGGACCCTACTGTCACCACTGGCAGAGTTTGTACTGACATCCAGGACAACAGATGACAACAAATGCAGCTGACTGGTGGTTCAGTGTCTGCAATGGGCCACACCGGAACAGCACCAGATCATGCAGAAGAATTACAGGGAGGAGGCACTATATGAGGAGCTGGATCTGCTGACCATGTTCTTGGTATGTGGAAGATGGTTACAGCCACCTTATGGGTCTCATTGAGCAGTGTGTTGCACCACTGCCCCCAGCCACCTTCCTGGGGCTAGCGTACAAAATCTCCAAGCAGGAACAAAATGAATGGAGACCAGAAATCCAGATATGTATGCCCAAGAAAAGCAGAATTTTATCCAGGACTTCTCCCAGGTTGTCAGGATGCTGACTGAGGATGAGATGGGGCACCCAGAGACAGGAGAGTCTATTACCTGGCTCAAAGAGGTCCTGGAGTACACTGCCACTGGAGACAAGTACCACTAGGGTTTGATGATGCTGGTAGCATTCCAGGAGCTGGCAGAGCCCAGGAAACAGGATGCTGATAGTCTCCAGCAGGTCCTGTCTGGGCTGTTGTGTGAACTGCTGTAAGCTTGCCCGTTt
>NM_001135822.2
GGGAACTACTCGACCCACAGAGCCGATCGCGGAGCGGATTCTGCTTTTAGGAGTACCCGCCAACAAGCGGGACCGAGCAGGAATCCGTATCTGGGAACAGAATGAACGGAGACCAGAATTCAGATGTTTATGCCCAAGAAAAGCAGGATTTCGTTCAGCACTTCTCCCAGATCGTTAGGGTGCTGACTGAGGATGAGATGGGGCACCCAGAGATAGGAGATGCTATTGCCCGGCTCAAGGAGGTCCTGGAGTACAATGCCATTGGAGGCAAGTATAACCGGGGTTTGACGGTGGTAGTAGCATTCCGGGAGCTGGTGGAGCCAAGGAAACAGGATGCTGATAGTCTCCAGCGGGCCTGGACTGTGGGCTGGTGTGTGGAACTGCTGCAAGCTTTCTTCCTGGTGGCAGATGACATCATGGATTCATCCCTTACCCGCCGGGGACAGATCTGCTGGTATCAGAAGCCGGGCGTGGGTTTGGATGCCATCAATGATGCTAACCTCCTGGAAGCATGTATCTACCGCCTGCTGAAGCTCTATTGCCGGGAGCAGCCCTATTACCTGAACCTGATCGAGCTCTTCCTGCAGAGTTCCTATCAGACTGAGATTGGGCAGACCCTGGACCTCCTCACAGCCCCCCAGGGCAATGTGGATCTTGTCAGATTCACTGAAAAGAGGTACAAATCTATTGTCAAGTACAAGACAGCTTTCTACTCCTTCTACCTTCCTATAGCTGCAGCCATGTACATGGCAGGAATTGATGGCGAGAAGGAGCACGCCAATGCCAAGAAGATCCTGCTGGAGATGGGGGAGTTCTTTCAGATTCAGGATGATTACCTTGACCTCTTTGGGGACCCCAGTGTGACCGGCAAAATTGGCACTGACATCCAGGACAACAAATGCAGCTGGCTGGTGGTTCAGTGTCTGCAACGGGCCACTCCAGAACAGTACCAGATCCTGAAGGAAAATTACGGGCAGAAGGAGGCTGAGAAAGTGGCCCGGGTGAAGGCGCTATATGAGGAGCTGGATCTGCCAGCAGTGTTCTTGCAATATGAGGAAGACAGTTACAGCCACATTATGGCTCTCATTGAACAGTACGCAGCACCCCTGCCCCCAGCCGTCTTTCTGGGGCTTGCGCGCAAAATCTACAAGCGGAGAAAGTGACCTAGAGATTGCAAGGGCGGGGAGAGGAGGCTCTCAATAAATAATCGTGTAACCTT

Publications

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