Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PSMA3P1
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:60179466-60180096  UCSC
Coordinates (T2T) chr14:54385762-54386392  UCSC
Coordinates (hg19) chr14:60646184-60646814  UCSC
Strand +
Parental Sequence NM_002788.4
Parental seq. overlap 551 bp
Parental seq. overlap (%) 57.6%
Genomic Region Intergenic
Retrocopy Summary PSMA3P1, located on chr14:60179466-60180096, is a retrocopy of the parental gene PSMA3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PSMA3
Full Name proteasome 20S subunit alpha 3
Also known as HC8|PSC3
Coordinate chr14:58244843-58272004
Strand +
Gene summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PSMA3P2
Bonobo Pan paniscus PSMA3P2
Gorilla Gorilla gorilla PSMA3P2
Orangutan Pongo abelii PSMA3P2
Gibbon Nomascus leucogenys PSMA3P1
Green monkey Chlorocebus sabaeus PSMA3P2
Crab-eating macaque Macaca fascicularis PSMA3P3
Rhesus Macaca mulatta PSMA3P3
Baboon Papio anubis PSMA3P3
Golden snub-nosed monkey Rhinopithecus roxellana PSMA3P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PSMA3P1
GGATCGGAATGTTGGAATGCTGGCAGCAGGTTTGTAGGCAGATGCTTGTTCTTTAGCAGACATAGCAAGAGAAGAAGTTTCCAACTTTAAATCTGACTTTGGTTATAACACTCCACTAAAACATCTTGCAAACAGAGTGGACATGTATGTACATGCATATACACTCTACAGTGCTGTTAGATCTTTTGCCTTCAGTTTCATGTTAGGGTCTTACAGTATGAATGACAGTGCACAATTTTCCATGATTGACTCATCAGGTGTTTTATATGGTTATTGGGCCTGTGCCACTGGCAAAGCCAGGCAAGCTGTAAAACAGAAATAGAAAAGCTTCAGATGAAAGAAATGACCTGCTATGATACTGTTACAGAAGTTGCTCAAGTAATTTACATAGTACATGATGACGCTAAGGATAAAGTTTACGAACTCAGCTGGGTTAGTGGTTTAACTAAAGGAAGACATGAAATTGTTTCAAAAGATATAAGGGAATAAGCAGATAAATATGCTAAAGAATCCTTGAGTGAAGAAGACAGGTCAGATGATGATAATATGTAAAATTTACTCCAGTATCTATTCTATGTTAAATTCCTATTACAATCCCGCGTAACTATATAGCCCTGTGGATTACACATAC
>NM_002788.4
ACTAGTTTGCGGCATCCTGTGGTATAGGGGAAGCGCTCCGGGCCTGGAATCCCTACGCGTCCCTTTGGGTTTAGCACGATGAGCTCAATCGGCACTGGGTATGACCTGTCAGCCTCTACATTCTCTCCTGACGGAAGAGTTTTTCAAGTTGAATATGCTATGAAGGCTGTGGAAAATAGTAGTACAGCTATTGGAATCAGATGCAAAGATGGTGTTGTCTTTGGGGTAGAAAAATTAGTCCTTTCTAAACTTTATGAAGAAGGTTCCAACAAAAGACTTTTTAATGTTGATCGGCATGTTGGAATGGCAGTAGCAGGTTTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAAGCTTCCAACTTCAGATCTAACTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCCATGTATGTGCATGCATATACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGGTCTTACAGTGTGAATGACGGTGCGCAACTCTACATGATTGACCCATCAGGTGTTTCATACGGTTATTGGGGCTGTGCCATCGGCAAAGCCAGGCAAGCTGCAAAGACGGAAATAGAGAAGCTTCAGATGAAAGAAATGACCTGCCGTGATATCGTTAAAGAAGTTGCAAAAATAATTTACATAGTACATGACGAAGTTAAGGATAAAGCTTTTGAACTAGAACTCAGCTGGGTTGGTGAATTAACTAATGGAAGACATGAAATTGTTCCAAAAGATATAAGAGAAGAAGCAGAGAAATATGCTAAGGAATCTCTGAAGGAAGAAGATGAATCAGATGATGATAATATGTAACATTTACTCCAGCATCTATTGTATTTTAAATTTCTACTCCAGTCCAATGTAACTATTTAGCCCTGGATTATACATACTGTCCAATTTTCATTAAATTTTTGTCTTATAA

Publications

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