Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PTBP1P
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:65279228-65281274  UCSC
Coordinates (T2T) chr14:59484081-59486127  UCSC
Coordinates (hg19) chr14:65745946-65747992  UCSC
Strand +
Parental Sequence NM_031991.4
Parental seq. overlap 1599 bp
Parental seq. overlap (%) 50.7%
Genomic Region Intergenic
Retrocopy Summary PTBP1P, located on chr14:65279228-65281274, is a retrocopy of the parental gene PTBP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PTBP1
Full Name polypyrimidine tract binding protein 1
Also known as HNRNP-I|HNRNPI|HNRPI|PTB|PTB-1|PTB-T|PTB2|PTB3|PTB4|pPTB
Coordinate chr19:797452-812316
Strand +
Gene summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PTBP1P1
Orangutan Pongo abelii PTBP1P1
Gibbon Nomascus leucogenys PTBP1P1
Green monkey Chlorocebus sabaeus PTBP1P1
Crab-eating macaque Macaca fascicularis PTBP1P1
Rhesus Macaca mulatta PTBP1P1
Golden snub-nosed monkey Rhinopithecus roxellana PTBP1P2
Marmoset Callithrix jacchus HNRNPCP14
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PTBP1P
TGCCTCCACTCCATCCCCCACGGGTCTGCTGTGTGTGCCATGGACGGCATTGTCCCAGATATAGCAGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTGCTTGTGTCACTAACAGACCATTTATCATGAGCAGCAACTCGGCCTCTGCAGCAAATGGACATGGCAGCAAGAAGTTCAAAGGTGACAGCAGAAGCGCCGGTGTCCCCTCCAGAGTGACCCACATCCAGAAGCTCCCATCGACGTCATCGAAGGGGAGGTGATCTCCCTGGAGCTGCCCTTTGGGAAGGTTACTAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATCAAGATGAGCACGGAGGAGGCTGCCAACACCATGGTGAATTACTACACCTCGGTGACGCCCGTGCTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGGGCTGAAGACCGACAGCTCTCCCAACCAGGCGCGGGACCCGGCAGCCCTCAGGCCGTGAACTCGGTCCAGTCGGGGAACCTGGCCTGGACTGCCCCGGCGGCAGCCGTAGACGCAGGGATGGCGATGGCCGGGCAGAGCCTGGTGCTCAGGATCATCGTGGAGAACCTCTTCTACCCCACGACCCTGGATGTGCTGCACCAGATTTTCTCCAAGTTCGGCACAGTGAAGACCATCACATTCATCAAGGACAACCAGTTCCAGGCCCTGCTGCAGTACACGGACCCCGAGAACGCCCAGCATACCAAGCTGTCGCTGGATTGGCAGAACACCTACAACGCCTGCCACACGCTGTGCATCGACTTCTCCAAGCTCATCAGCCTCAACGTAAAGTACAACAACGACAAGAGCCGCGACTACCACGCCCGGACCTGCCCTCCGGGGACAGCTAGCCCTCGCTGGACCAGACATGGCCGTGGCCTTCGACCTTTCAGTTCCCAACATCCACGGAGCCCTGGCCCCCCGGCCATCCCCTCGGCGGTGGCGGCAGCTGCAGCGGCAGGCCAGATCGCCATCCTGGGCCTGGCGGGGACAGGAAATTCTGTCTTGCTGGTCAGCGGCCTCAACCCAGAGAGAGTCACACCCCAAAGCCTCTGCCCAAAGCCTCTTTATTCTTTTCAGCGTCTACGGGGACGTGCAGCGCGTGAAGATCCCGTTCAATAAGAAGGAGAACGCTCTGGTTCAGATGGCGGACGGCAACCAGGCCCAGCTGGCCATGAGCCACCTGAACTGGCACAAGCTGCACGGGAAGCCCATCCGCATCTCATCCGTATCACGCCCTTGAAGCACCAGAACGTGCAGCTGCCCCGCGAGGGCCGGGAGGACCAGGGCCTGACCAAGGACTATGGCAACTCGCCCCTGCACCGCTTCAAGAAGCCAGGCTTCAAGAACTTCCAGAACATATTCCCGCCCTCGGCCACCGTGCACCTCTCCAACATCCCGCCCTCAGTATCCGAGGAAGATCTCAAGGTCCTCTCCTCCAGCCATGGGGGCATAGTCATAGGATTCAAGTTCTTCCAGAAGAACCGCAAGATGGCGCTGATCCAAATGCGCTCCGTGGAGGAGGCGGTCCAGACCCCCATTGCCCTACACAACCACGACATCTGGGAGAACCACCACCTGCGGGTCTCCTTCTCCAAGTCCACCATCTATGGGCACAGGCCCACCACAGCCGGGCCCCCTGGCGACAACTTCCATCATTCCAAAAAAAGCGACTTTAAAAAGCAGCTGAAGTGACCTTAACTGACCAGAGA
>NM_031991.4
ATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGCGGGCCCAGGCGGCCCTGCAGGCGGTGAACTCGGTCCAGTCGGGGAACCTGGCCTTGGCTGCCTCGGCGGCGGCCGTGGACGCAGGGATGGCGATGGCCGGGCAGAGCCCCGTGCTCAGGATCATCGTGGAGAACCTCTTCTACCCTGTGACCCTGGATGTGCTGCACCAGATTTTCTCCAAGTTCGGCACAGTGTTGAAGATCATCACCTTCACCAAGAACAACCAGTTCCAGGCCCTGCTGCAGTATGCGGACCCCGTGAGCGCCCAGCACGCCAAGCTGTCGCTGGACGGGCAGAACATCTACAACGCCTGCTGCACGCTGCGCATCGACTTTTCCAAGCTCACCAGCCTCAACGTCAAGTACAACAATGACAAGAGCCGTGACTACACACGCCCAGACCTGCCTTCCGGGGACAGCCAGCCCTCGCTGGACCAGACCATGGCCGCGGCCTTCGGCCTTTCCGTTCCGAACGTCCACGGCGCCCTGGCCCCCCTGGCCATCCCCTcggcggcggcggcagctgcggcggcAGGTCGGATCGCCATCCCGGGCCTGGCGGGGGCAGGAAATTCTGTATTGCTGGTCAGCAACCTCAACCCAGAGAGAGTCACACCCCAAAGCCTCTTTATTCTTTTCGGCGTCTACGGTGACGTGCAGCGCGTGAAGATCCTGTTCAATAAGAAGGAGAACGCCCTAGTGCAGATGGCGGACGGCAACCAGGCCCAGCTGGCCATGAGCCACCTGAACGGGCACAAGCTGCACGGGAAGCCCATCCGCATCACGCTCTCGAAGCACCAGAACGTGCAGCTGCCCCGCGAGGGCCAGGAGGACCAGGGCCTGACCAAGGACTACGGCAACTCACCCCTGCACCGCTTCAAGAAGCCGGGCTCCAAGAACTTCCAGAACATATTCCCGCCCTCGGCCACGCTGCACCTCTCCAACATCCCGCCCTCAGTCTCCGAGGAGGATCTCAAGGTCCTGTTTTCCAGCAATGGGGGCGTCGTCAAAGGATTCAAGTTCTTCCAGAAGGACCGCAAGATGGCACTGATCCAGATGGGCTCCGTGGAGGAGGCGGTCCAGGCCCTCATTGACCTGCACAACCACGACCTCGGGGAGAACCACCACCTGCGGGTCTCCTTCTCCAAGTCCACCATCTAGGGGCACAGGCCCCCACGGCCGGGCCCCCTGGCGACAACTTCCATCATTCCAGAGAAAAGCCACTTTAAAAACAGCTGAAGTGACCTTAGCAGACCAGAGATTTTATTTTTTTAAAGAGAAATCAGTTTACCTGTTTTTAAAAAAATTAAATCTAGTTCACCTTGCTCACCCTGCGGTGACAGGGACAGCTCAGGCTCTTGGTGACTGTGGCAGCGGGAGTTCCCGGCCCTCCACACCCGGGGCCAGACCCTCGGGGCCATGCCTTGGTGGGGCCTGTGTCGGGCGTGGGGCCTGCAGGTGGGCGCCCCGACCACGACTTGGCTTCCTTGTGCCTTAAAAAACCTGCCTTCCTGCAGCCACACACCCACCCGGGGTGTCCTGGGGACCCAAGGGGTGGGGGGGTCACACCAGAGAGAGGCAGGGGGCCTGGCCGGCTCCTGCAGGATCATGCAGCTGGGGCGCGGCGGCCGCGGCTGCGACACCCCAACCCCAGCCCTCTAATCAAGTCACGTGATTCTCCCTTCACCCCGCCCCCAGGGCCTTCCCTTCTGCCCCCAGGCGGGCTCCCCGCTGCTCCAGCTGCGGAGCTGGTCGACATAATCTCTGTATTATATACTTTGCAGTTGCAGACGTCTGTGCCTAGCAATATTTCCAGTTGACCAAATATTCTAATCTTTTTTCATTTATATGCAAAAGAAATAGTTTTAAGTAACTTTTTATAGCAAGATGATACAATGGTATGAGTGTAATCTAAACTTCCTTGTGGTATTACCTTGTATGCTGTTACTTTTATTTTATTCCTTGTAATTAAGTCACAGGCAGGACCCAGTTTCCAGAGAGCAGGCGGGGCCGCCCAGTGGGTCAGGCACAGGGAGCCCCGGTCCTATCTTAGAGCCCCTGAGCTTCAGGGAAGGGGCGGGCGTGTCGCCGCCTCTGGCATCGCCTCCGGTTGCCTTACACCACGCCTTCACCTGCAGTCGCCTAGAAAACTTGCTCTCAAACTTCAGGGTTTTTTCTTCCTTCAAATTTTGGACCAAAGTCTCATTTCTGTGTTTTGCCTGCCTCTGATGCTGGGACCCGGAAGGCGGGCGCTCCTCCTGTCTTCTCTGTGCTCTTTCTACCGCCCCCGCGTCCTGTCCCGGGGGCTCTCCTAGGATCCCCTTTCCGTAAAAGCGTGTAACAAGGGTGTAAATATTTATAATTTTTTATACCTGTTGTGAGACCCGAGGGGCGGCGGCGCGGTTTTTTATGGTGACACAAATGTATATTTTGCTAACAGCAATTCCAGGCTCAGTATTGTGACCGCGGAGCCACAGGGGACCCCACGCACATTCCGTTGCCTTACCCGATGGCTTGTGACGCGGAGAGAACCGATTAAAACCGTTTGAGAAACTCCTCCCTTGTCTAGCCCTGTGTTCGCTGTGGACGCTGTAGAGGCAGGTTGGCCAGTCTGTACCTGGACTTCGAATAAATCTTCTGTATCCTC

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