Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAGOH3P
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:68861724-68862793  UCSC
Coordinates (T2T) chr14:63068587-63069658  UCSC
Coordinates (hg19) chr14:69328441-69329510  UCSC
Strand +
Parental Sequence NM_018048.5
Parental seq. overlap 707 bp
Parental seq. overlap (%) 27%
Genomic Region Intergenic
Retrocopy Summary MAGOH3P, located on chr14:68861724-68862793, is a retrocopy of the parental gene MAGOHB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAGOHB
Full Name mago homolog B, exon junction complex subunit
Also known as MGN2|mago|magoh
Coordinate chr12:10604190-10613609
Strand -
Gene summary Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAGOHBP1
Bonobo Pan paniscus MAGOHBP1
Gorilla Gorilla gorilla MAGOHBP1
Orangutan Pongo abelii MAGOHBP1
Gibbon Nomascus leucogenys MAGOHBP1
Green monkey Chlorocebus sabaeus MAGOHBP2
Crab-eating macaque Macaca fascicularis MAGOHBP1
Rhesus Macaca mulatta MAGOHBP1
Baboon Papio anubis MAGOHBP1
Golden snub-nosed monkey Rhinopithecus roxellana MAGOHBP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAGOH3P
AGTTGTCTGGGTTTTCAGCGGGCTTCCCAGGGACAAAAATGGTTATGGCTAGCGATTTCTACCTGCGCTACTACGTAGGGCACAAGGGCAAGTTTGGGCATGAGTTTTTGGAGTCCGAATTTCAGCTGGATGGAAAGCTTAGATATGCCAACAGTAGCAATTACAAAAATGACGTCATGATCAGAAAAGAGGCTTACGTGCACAAGAGTTTAATGGAAGAACTGAAGAGAATTATTGATGACAATGAAATCACAAAAGAAGATGATGGTTTGTGGCCTCCCCCTGACAGGGCTGGCCGACAGGAGCTTGAAATTGTAATTGGAGATGAGCACATATCcCACATATCTTTTACCACATCAAAAATAGGTTCTCTTATTGATGTAAATCAGTCAAAGGATCCCGAAGGCCTTCGAGTATTTTACTATTTGGTACAAGACTTGAATTGTTTAGTTTTCAGTCTCATTGGATTACACTTCAAGATTAACCCAATTTAAATTGTATGTTTTTCAAGCTGTTTGTATATTTAATTAAGGGATGGGAGGGGTTATTTGTCATTTACAATATTGGTTTTTTTTATTAATGTGAAGCTAACAAAAAAAATTGTATGTAAACTGAAAATAAGAAAATACATTAGCAGGCTTAATGGTTACCCTTACTTGAGTCCACATGGGTTGGACAGTCCCCACTGTCCCCACATTAAATTCTGTAAATAAAAGCCACCTTTTGTTAAAAATTTGCTCTAATAAAACATACCAAATCCTG
>NM_018048.5
ATTCCGCGCGATGACGTCACTGCAAGGCGCCGGGGGACACGTTGGCTGCGTTTTCGGCGGGCTTCCCGGGTACAAAAATGGCTGTGGCTAGCGATTTCTACCTGCGCTACTACGTAGGGCACAAGGGCAAGTTTGGGCACGAGTTTCTGGAGTTCGAATTTCGGCCGGACGGAAAGCTTAGATATGCCAACAACAGCAATTACAAAAATGATGTCATGATCAGAAAAGAGGCTTATGTGCACAAGAGTGTAATGGAAGAACTGAAGAGAATTATTGATGACAGTGAAATTACAAAAGAAGATGATGCTTTGTGGCCTCCCCCTGATAGGGTTGGCCGACAGGAGCTTGAAATTGTAATTGGAGATGAGCACATATCTTTTACCACATCAAAAATAGGTTCTCTTATTGATGTAAATCAGTCAAAGGATCCTGAAGGCCTTCGAGTATTTTACTATTTGGTACAAGACTTGAAATGTTTAGTTTTCAGTCTTATTGGATTACACTTCAAGATTAAACCAATTTAAATTGTATGTTTTCAGGCTGTTTGTATATTTAATTAAGGGATGGGAGGGGTTATTTGTCATTTACAGTATTGGGGTTTTTATGAATGTGAAGCAAACAAAAAAAATTTGTATGTAAACTGAAAATAAGAAAATACATTAGCAAGCTTAATGGTTATCCTTACTTGAGTCCATATGGGTTGGACAGTCCCCACACACATTAAATTCTGTAAATGAAAGCCACCTTTTGTTAAAAATTTGCTCTAATAAAACATACCAAATCCTGGTTGCAGAGTAGTTTTTTGTTTTTTCCAGGAGGCTATGTCTCTAATTCACTTTAGAGATAATAAGAAATTGTTCTGGTAGATATATCCTGTGACAGAAGATACTTTAGGTGGAACTATGTAGCCAGATTCCCATCCATGAAAGGCAAGTGTAGATTGTCCCTTATTTCCTTCATACATGATTGGATTTAATTTTGGGGGGCTTATACAAGGTCTAGTTTTTTTTTACAGTTATGACAAACCCCTCAGGGATTATTCACATTTAAATATTTTCAGTTATAAGCAGTGAGGTCCTAAAGTGTTACAAGAGTACAGTCTACCCCATGTTAGGCATATCTTTGATTATGTCTTTATTCCTTATTTCACAATGTATTTGGTGTGTAGGGGAGGGGGGAGAACTAAATGAGTTTTCAGCTTTATAAATTGTTAAACATTTAGACAAACATATATGTATGTATGAATGTACATAAATATTTTTAACTCCTATTGACCACGAGTCTCACTTCAGTTTCCCAGTTCCTTTCAACCTCTTTCTGATAGATTTCCTCTTTCATTACTTTTAGTAACCATGTTCCTTGTTTCCTTTTATTCTTCCATCTGAAGCCCCACTCTTAAAAAGTTGCACTGTTCCAGTAGTTATAATCCACTTGCCCTAGGAACAAGTTAGCACTGAATTTTGGGTGGAATAATTAGTTTCTGAAGGCTTGCCAGGACTCCTGAGCAGGTAGGCTCTAGAGTCGGgcagtccaataacttttttgcaataatggaaacgttctatgtgcagtccaatagggtagcaactggccaaatgaggcctactgattacttgaggtgtgccttgtataactgaATTTATGGTGCTATTTAAACAATTTTTTTCTAACGTGAAAAGGATAAAACATTAAAAACTCTTGagaactataaagtgaacacctatatgcctacccctacctagattctatacttaacatcttttttactgtaatatctctattataATAAATCTTGGTTTTTCACTTAACTGGTGTAATTGGTGCCAATAAACTACTTTTTTTGTAGTGCtatttaattttgattaaatttaggtagccacgtgtctagcggctaccgtttggacagtatagctctagagcatGGCTTGGTAACCTGTTTGCCATGGAGCACTAGATGGTCCTTTTCACTCCTCAAAATGCATGCCCATTGTCTTCAGGTTTGCCATGGAAAGTCAAATGATTTCCACTTCATTATGCAAGTACGCTATCATCTTCAGGTCTTTTGTATGTAAAATGTTTCTGTTCCAGTTGTAGACCTTGATGATTGTGCAGTATGAAATCGTATTGTAATTTTCTTGCATTTAGATGTCAACCTCAGAAACAGGAACAATCGTCTTTTGAACTTCCAGTAGGCCCACAGTTGTTGGTTGTTCCTCAAAACAGGTTGTGGCTCCTGTTGAATAAGATGATCCATTAAAAACTGAACAAGGTTGAGGAGAAATAGTGCTTACGTTGAAAAATCTTTAAGTCTTTGTCCCCGTTCTCTAACTTCCTTACGTTTTCGTTTATTTAGCTCTATCCCCACTATCTACTAGAATTTCTCATATTTAAACCAAGATGGGAGACTAGGTCATTAGGAAAATATTACCGTCTACAATTTTCTTATACTTTGATCTGTCTTTTATTTGATTGTAAGTTGCTGATGGACAGTGATCATTAGAAACTGAATTTTGTATAATACTAGTTTTATATGAAACTAGATTTTTATTGCGCTCAGGTTATGTTCCTTTTACCTCCTTCCTTAATAAAGAGACCACTTGAAATAA

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