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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NT5CP2
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:73539328-73539763  UCSC
Coordinates (T2T) chr14:67746838-67747273  UCSC
Coordinates (hg19) chr14:74006032-74006467  UCSC
Strand -
Parental Sequence NM_014595.3
Parental seq. overlap 354 bp
Parental seq. overlap (%) 39.2%
Genomic Region Intragenic (HEATR4)
Intragenic (ACOT1)
Retrocopy Summary NT5CP2, located on chr14:73539328-73539763, is a retrocopy of the parental gene NT5C. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NT5C
Full Name 5', 3'-nucleotidase, cytosolic
Also known as DNT|DNT1|HEL74|P5N2|PN-I|PN-II|UMPH2|cdN|dNT-1
Coordinate chr17:75130228-75131965
Strand -
Gene summary This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NT5CP1
Bonobo Pan paniscus NT5CP1
Gorilla Gorilla gorilla NT5CP1
Orangutan Pongo abelii NT5CP1
Gibbon Nomascus leucogenys NT5CP1
Green monkey Chlorocebus sabaeus NT5CP1
Crab-eating macaque Macaca fascicularis NT5CP1
Rhesus Macaca mulatta NT5CP1
Baboon Papio anubis NT5CP1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NT5CP2
GTGCTGATGGACAGGGACCGCGTGCTGGCAGCTTCCAGACGGCATCCTGTGGGGCTTCAGCCGCCGCTTCTCAGGGAGCTGCATGTGACACTGCAGCAGCACCGCAGCTTCCTGGTCTGGAAGCAGTACCTCACCCTGCTGCCGGACCTGGTGGATAAAGTGGCCCATGGGTGTGAAGCCCTAGGCTTTTCCCTAGTCTTGAAGCCCAACCCCAGAGGGCCTTGCAAGAGATGAAGCACATGCAAAACACCGAGGTCTTCACACTGCACCAGCCCCTGCCAAAGTATGACCACTGTGTGGGTGAGAAGCACCGCTGGGTAGAGCAGCACCTGGAGTCCCAGCTTGTGGAGTGAATTATCCTGACAATGGACAAGACCGTGGTCTTTGGGGACTTGCTCACTGATGACAAGGATACCATTCGAGGCCAAGAGGAGAG
>NM_014595.3
AGACCCCGAGAGCTCGCAGCTCCGGCCCGGCGGCGATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCCGGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAACGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAAGTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCCTTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGCCCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTGGGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGACCTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCACATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTGCTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGGGAATGAGCGGGGATGCCGCGGGCAGCAGCTGGAGCTAAAGGAAGGGCAGGCCCACAGGGGCCACCGCAGAGCCGAGTCGGGGCGGCATCGTGCTGGTGCCTCTGGCCCCGTGGAGTGGAGCAGGCAGATACCGTTAAGCGCTGTGCTACCGGGCCCCAGGCCCAGCCACCCGGTACCTCCCGAGAGGCTGTCCCTGGACCCTGGCTGGCATGGAAATACAGTGGGAAAACCAGTCGGGACCTTTAATAAAAGACCTTGGCTTTCTA

Publications

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