Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DPPA5P4
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:75292007-75292349  UCSC
Coordinates (T2T) chr14:69501400-69501742  UCSC
Coordinates (hg19) chr14:75758710-75759052  UCSC
Strand -
Parental Sequence NM_001025290.3
Parental seq. overlap 311 bp
Parental seq. overlap (%) 47.1%
Genomic Region Intergenic
Retrocopy Summary DPPA5P4, located on chr14:75292007-75292349, is a retrocopy of the parental gene DPPA5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DPPA5
Full Name developmental pluripotency associated 5
Also known as ESG1
Coordinate chr6:73353063-73354276
Strand -
Gene summary This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DPPA5P2
Bonobo Pan paniscus DPPA5P2
Gorilla Gorilla gorilla DPPA5P2
Orangutan Pongo abelii DPPA5P2
Gibbon Nomascus leucogenys DPPA5P4
Green monkey Chlorocebus sabaeus DPPA5P2
Crab-eating macaque Macaca fascicularis DPPA5P1
Rhesus Macaca mulatta DPPA5P1
Baboon Papio anubis DPPA5P3
Golden snub-nosed monkey Rhinopithecus roxellana DPPA5P2
Marmoset Callithrix jacchus RPS15AP38
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DPPA5P4
AATCCCTTACATCGAGCAGATGAGCAAGGCCATGCTCCAGCTGAAGGCTCTGGAGTCTTCAGACCTCACCGAGGTCGTGGTTTACAGCTCCTATTGGTACAAGCTCCAAACCAAGTGGATGCTCCAGTCCATGGCTGAGTGGCACTGCCAGCACCAGGAGCAAGGGATGCTCAAACTTGCAGAAGCCATGAATGCCCTCAAACTAGACCCTTGGATGAAGCGAACCAGCTTCCGGCCAATGTGATGGAGGCCAGGATGTAGAGATTAGGTTGTGGCCAGAGCCGGAGTGGTTCCAGCTTGGTTTAAACTCTGCTCCAGCCTGATGAATTAAGGAAAAACCATC
>NM_001025290.3
GATTAGGCCTGGTTTGCGCTGGAGAGTGGTCTTGGTTGTGAGGGTCATAAGATGGGAACTCTCCCGGCACGTAGACATATCCCGCCGTGGGTGAAAGTTCCCGAAGACCTGAAAGATCCAGAGGTGTTCCAGGTCCAGACGCGGCTGCTGAAAGCCATTTTCGGCCCGGACGGATCTCGAATCCCTTACATCGAGCAGGTGAGCAAGGCCATGCTCGAGCTGAAGGCTCTGGAGTCTTCAGACCTCACCGAGGTCGTGGTTTACGGCTCCTATTTGTACAAGCTCCGGACCAAGTGGATGCTCCAGTCCATGGCTGAGTGGCACCGCCAGCGCCAGGAGCGAGGGATGCTCAAACTTGCCGAAGCCATGAATGCCCTCGAACTAGGCCCTTGGATGAAGTGAACCAGTTTCCAGCCAATGCAATGAAGCCGGGTTGCAGAGATTAGGTTGTGGCCAGAGCTAGAGTGATTCCTTAAGCTTGTTTTAAAATCTGCTCCAGCCTAAAGAGTTAAGGGAAAACCATTTGTTCCCTTAAAGAGTTAAGGGAAAACCCTTGGCTCTGAGTCTTGTTGTGAATATTTCTTTGATGATTGTTAATAAAAAGTGTTTTTTCTTTTTTCCCATTTTTAAAAATAACAATAAAGTTTTAAATAAGTTGA

Publications

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