Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MPPE1P1
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Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:89109888-89111376  UCSC
Coordinates (T2T) chr14:83333549-83335034  UCSC
Coordinates (hg19) chr14:89576232-89577720  UCSC
Strand -
Parental Sequence NM_001330563.2
Parental seq. overlap 1338 bp
Parental seq. overlap (%) 40.8%
Genomic Region Intergenic
Retrocopy Summary MPPE1P1, located on chr14:89109888-89111376, is a retrocopy of the parental gene MPPE1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MPPE1
Full Name metallophosphoesterase 1
Also known as Cdc1|PGAP5
Coordinate chr18:11882622-11908661
Strand -
Gene summary Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MPPE1P1
Bonobo Pan paniscus MPPE1P1
Gorilla Gorilla gorilla MPPE1P1
Orangutan Pongo abelii MPPE1P1
Gibbon Nomascus leucogenys MPPE1P1
Green monkey Chlorocebus sabaeus MPPE1P1
Crab-eating macaque Macaca fascicularis MPPE1P1
Rhesus Macaca mulatta MPPE1P1
Baboon Papio anubis MPPE1P1
Golden snub-nosed monkey Rhinopithecus roxellana MPPE1P1
Marmoset Callithrix jacchus MPPE1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.050.10.150.2
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>MPPE1P1
TACCAATCTCTCTCTCTTTAAAAGGTGAGGTGAATCGGTGATTTTCCTGAAAAATTACAGGTACCCAGCTAAGATCTGAATGCCATCACCCTACCCAGGGCTCTGCAGTTTTCTCATGGTGAACCCTTGATGGATTTGTTAGTTGCTTGAGAAATGGCTATGAGTGGATTGAGGTTTGGAAGACAGAGTTTTCATCCGTTGAAGAGGAAGAGTTGATTGCTGTTGAAATTCATTGTCTTCTCTGTGCTTCTGTTTTGTGAATTTTTAATCTATTACTTAGTGATCTTTTGGTGTAATTGGCCTGAAGCGAAAACCGCAGCCTATGATGGTGAACAGGCCACGTGTGAGCCTGTGCTCAAAGCCATGTTTTTGGCTGACACCCACTTGCTTAGGGAATTCCTAGGTCACTGGCTGGACAAATTACGAAGGGAATGGCAGGTGGAGAGAGCCTTCCAGACAGCTCTGTGGTTGCTGCAGCCGGAAGTCGTCTTCATCCTGGAGGATGTCTTTGATGAAGGGAAGTGGAGCACCTCTGAGGCCTGGGTGGATGATGTGGAGCAGTTTCGGAAAATGTTCAGACACCCAAGTCATGTGCAGCTGAAGGTAGTTGCTGGAAACCATGACACTGGCTTCCACTATGAGACGAACACATACGAAGTAGAACGGTTTGAGAAAGTGTTCATCTCTGAAAGCCTGTTTTCTTGGAAAGGATTAACTTCATGATGGTCAACAGCATGGCACTGAAGGGGGACAGCTGTGGCATCTGTTCTGAAGCAGAAGCAGAGCTCACTGAAGTTTCTTACAGACTGAACTGCTCCCAAGAGCGTTATCCTCTGTATTGGAGAAGCGACACTAACTGTTCTGGGGAAGATGTTGCTCCTCCGGAGGAAAAGAACACCCCATTAAGGAGAATTATGATGTGCTTTCTCGGGAGGCATCGCAAAAGCTGCTGTGTTGACTCCAGCCACACCTGGTCCTCAGCGGCCACACGCACAGCACCTGCGAGGTGCACCACGGGGGATGAATCCCCGAGCTCAGCCTCTCATCTTTCAGTTGGAGGAACAGAAACAACCCCAGTTTCATTATGGGTAGCATCACACCCACAGACTATGCCCTCTCCAAGTGCCACCTACCACCTGAGGACGTGGTCTTGATCATCTACTGTGGAGTGGTGGGCTTCCTTGTGGTTCTGACACTTACTCACTTTGAGCTTTTAGCCTCACCTTTTCTTTCTGAGGTTTGAACCTGCTCAGAAAGCATAAGACAAGGTGAAAAGCAAGCAACATATGCACTTAGTAATAAATATCAAAGCCCAAGAAATGGAACTTTGGGCAGAGATCATGTTAGACTCAAGTGGATAATGAGACCAAATATAGGCCATCTCTGCATATCACAGAAATTCTCAATCACTGAAACGAGTTACTGCAGAACAAGTAGTAGATTGTACTGTTCTCATGCTATAAAAATGGAACAGCTACTCTa
>NM_001330563.2
GCAGTTCCCGGGTCCCTCGGCCACCGAAGCCACCCTGCCCTGGTGAAAGGGCTCCCGCACCGCCCGGTGCTCCCCATCTGCCTGGCGTTGTGCGCAGAGCTGGAAAGCATGGCTGTTATAAATGAATTCTGATTTTGGGGAGCAGATGCCAACTTAGAGCCTCGTACCAATCTCTCTGTCTTTAAAAGATGAGGTGACTTGGTGATTTTCCTGGAAAATTATAGGTGCCCAGCTAAGACCTGAATGCCATCACCCTCCCCAGGGCTCTGCAGTTTTCTCGTGGTGAACCCTTGATGGATTTGTTGTTGCTTGAGAAATGGCGATGATCGAATTGGGGTTTGGAAGACAGAATTTTCATCCATTAAAGAGGAAGAGTTCATTGCTGTTGAAACTCATAGCTGTTGTCTTTGCTGTGCTTCTATTTTGTGAATTTTTAATCTATTACTTAGCGATCTTTCAGTGTAATTGGCCTGAAGTGAAAACCACAGCCTCTGATGGTGAACAGACCACACGTGAGCCTGTGCTCAAAGCCATGTTTTTGGCTGACACCCATTTGCTTGGGGAATTCCTAGGCCACTGGCTGGACAAATTACGAAGGGAATGGCAGATGGAGAGAGCGTTCCAGACAGCTCTGTGGTTGCTGCAGCCGGAAGTCGTCTTCATCCTGGGGGATATCTTTGATGAAGGGAAGTGGAGCACCCCTGAGGCCTGGGCGGATGATGTGGAGCGGTTTCAGAAAATGTTCAGACACCCAAGTCATGTACAGCTGAAGGTAGTTGCTGGAAACCATGACATTGGCTTCCATTATGAGATGAACACATACAAAGTAGAACGCTTTGAGAAAGTGTTCAGCTCTGAAAGACTGTTTTCTTGGAAAGGCATTAACTTTGTGATGGTCAACAGCGTGGCGCTGAACGGGGATGGCTGTGGCATCTGCTCTGAAACAGAAGCAGAGCTCATTGAAGTTTCTCACAGACTGAACTGCTCCCGAGAGCATTATCCTCTGTATCGGAGAAGTGATGCTAACTGTTCTGGGGAAGACGCTGCTCCTGCAGAGGAAAGGGACATCCCATTTAAGGAGAACTATGACGTGCTTTCACGGGAGGCATCACAAAAGCTGCTGTGGTGGCTCCAGCCGCGCCTGGTTCTCAGTGGCCACACGCACAGCGCCTGCGAGGTGCACCACGGGGGCCGAGTCCCCGAGCTCAGCGTCCCATCTTTCAGTTGGAGGAACAGAAACAACCCCAGTTTCATCATGGGTAGCATCACGCCCACAGACTACACCCTCTCCAAGTGCTACCTCCCACGTGAGGATGTGGTTTTGATCATCTACTGTGGAGTGGTGGGCTTCCTTGTGGTCCTCACACTCACTCACTTTGGGCTTCTAGCCTCACCTTTTCTTTCTGGTTTGAACTTGCTCGGAAAGCGTAAGACAAGATGAAGAGCAGGCGCCATTATAAATATCAAAGCCCAAGAAATGGAACTTTGGGCAGAGATCATGTTAGAATCAAGTGGATGATGAGACCAATTACAGGCCGTCTCTCTGCACAGCACAGAAATTCTCAATCACTGAAATGAGTAACTGCAAAATAAATAGTTGATTGTACTGTTCTCATGCTATAAAAGTGGACAGGTACTCTACAACAAATCTGTTTTCTCATTTTTATCAAATATATGTATCATCAAAGGTTGCATCTGTACAGTATGTAAATGCTATTAATGTCGTCACTCACATGCACGACAGTCCTTGTTCCCCCAGGAAGGGCCTGGTGGCCCCAGCACACACTTGGGATTATGTGTATACATAAATAAATATTGGGCTGTTTCCCTCTTCCTGTGAAGTGGTTCTCAAATTCCTATGTACTGTAAAGCTGTACCCTTAAAAGTACAGATGTggccgggcacagtggctcacacctgtaatcccagcactttgggaggctgaggcgggtggatcacttgaggtcaggagttcaagaccagcctggccaacatggtgaaacctcgtctccgctagaaatacaaaaattagccaagcatggtagcaagtgcctataataccagctgaggctgaggcaggagaatcccttgagcccgggaggcggaggttgcagtgagccaagatcatgccactgcactccagcctgggcaacagagtgagactccgtctcaaaaaatatatttaaaaaaaaaaaaGTACAGATGTGATGTGCAGAACATATTGTTTTCGTAGATTTTTATACTTGATCAATTAATGGAATCAGATTTTTAGATAAGTGTAATTTTCTCTATAGGAGACCACGTTGCTACATCTGTTAATGCCTGTCAGTGATCAAAAGAAACTTAAAAAGTGGAATGGGATATGGCTTTTGGTACCTGAAAATAAATGCTTTAATAATTGTAAGCCAGATAAAAGTTATTCTTTTTGTTTTTTTTCTTAACAGTCTGGCTGTTGTTTGAATTAAACTCTTAAACAGGATGTTTAGTTAGAGGGTAATTGTTGAGTAATGATGCATACAACAGCATACTTCCCTTTCTTGCTGGGGGTGCAGCTTTTCAGTTTTCTTGTTTTACTTTGACAGTGCAAGGGGAACTGAAAATAATTTCCATTGTATTATTTATCTTAGTTCAGCTGAGGGCTTTATGAGACAGTGGATGGGGAGGCAGTAAGACGGTGATGAGATAAAATGTGTGTGTTGCACTGACTGTCTATAAAGTTATCCTTTCTTCATGAAAAAGTAGCATTTAAATCTGGATGAGTTTATAAAGGATTACAAAATGCTGATTTATAGAGTAAACTTTAAAATATTAAAGACTAAAGACTAAAAGAAGAGTAATAATGAAGTAATGTAGGCTGTCACTTCTCTAGATTTGTATTGTTGAAAATTTAACTTTGGACATCTTTATAGATTATTATTTTAGACCTACAAAAACTACCCTCAACTCTGTGGCTACAGCTAGAATATGAAGCATCATTGCTACACCAGTTCTTACTTTCTAGATATTGTTGGTGTGTCATAATGTTTGAGGCTGTATTTGTAAGTCTTGCAAGTGTGAGAAAGAGCCGTATCTTTTGACTTTATACTTCAGATTAAGGTTTTGTAATGTTTCTTCTTCAAAAGGCAAGTGAAGCTGTCATCCTCATTCTCCTAGGCCAGACACAAACATTGACACGTCAAGGttttttttttttttttttttggcctgagtctcactttgatgtccaggctggagtgcgatggcacgacctcggctcactgcaat

Publications

PMID - Link Title
No publications available for this retrocopy