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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS18P23
Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:90766494-90767028  UCSC
Coordinates (T2T) chr14:84991965-84992499  UCSC
Coordinates (hg19) chr14:91232838-91233372  UCSC
Strand +
Parental Sequence NM_022551.3_4
Parental seq. overlap 496 bp
Parental seq. overlap (%) 90.3%
Genomic Region Intragenic (TTC7B)
Retrocopy Summary RPS18P23, located on chr14:90766494-90767028, is a retrocopy of the parental gene RPS18. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS18
Full Name ribosomal protein S18
Also known as D6S218E|HKE3|KE-3|KE3|S18
Coordinate chr6:33272075-33276511
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPS18P13
Bonobo Pan paniscus RPS18P14
Gorilla Gorilla gorilla RPS18P13
Orangutan Pongo abelii RPS18P13
Gibbon Nomascus leucogenys RPS18P17
Green monkey Chlorocebus sabaeus RPS18P16
Crab-eating macaque Macaca fascicularis RPS18P12
Rhesus Macaca mulatta RPS18P12
Baboon Papio anubis RPS18P10
Golden snub-nosed monkey Rhinopithecus roxellana RPS18P6
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS18P23
GACAGGAGGCCTACGTGCCACCTCTTGTACTGCCGCCATGTCTCTAGTGATCCCTGAAAAGTTCCAGCATATTTTGTGAGTACTCAACACCATCATCGATGGGCAGTGGAAAACAGCCTTTACCATCCCTGCCATTAAGGGTGTGGGCCAAAGATATGTTCATGTGGTGTTGAGGAAAGCAGACATTGACTGCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGGAACGTGTGATCACCATTATGCAGAATCCATGCCAGTACAAGATCCCAGACTGGTTCTTGAACACACAGAAGGATGTAAAGGATGGAAAATATAGCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCATGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGTGCCACTCCTGGGGCCTTCATGTCCAAAGTCAGCACACCAAGACCACTGGCCGCCATGGCCGCACTGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTTAATAAATAGTT
>NM_022551.3_4
CTCTCTTCCACAGGAGGCCTACACGCCGCCGCTTGTGCTGCAGCCATGTCTCTAGTGATCCCTGAAAAGTTCCAGCATATTTTGCGAGTACTCAACACCAACATCGATGGGCGGCGGAAAATAGCCTTTGCCATCACTGCCATtaagGGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTTAATAAATAGTTTATATACCTATGGC

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