Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name VDAC3P1
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Plot displaying the genomic locations of a retrocopy (in chr14) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr14:99964463-99965814  UCSC
Coordinates (T2T) chr14:94197504-94198855  UCSC
Coordinates (hg19) chr14:100430800-100432151  UCSC
Strand +
Parental Sequence NM_001135694.2
Parental seq. overlap 1266 bp
Parental seq. overlap (%) 81.9%
Genomic Region Intergenic
Retrocopy Summary VDAC3P1, located on chr14:99964463-99965814, is a retrocopy of the parental gene VDAC3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name VDAC3
Full Name voltage dependent anion channel 3
Also known as HD-VDAC3|VDAC-3
Coordinate chr8:42391624-42405937
Strand +
Gene summary This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes VDAC3P2
Bonobo Pan paniscus VDAC3P2
Gorilla Gorilla gorilla VDAC3P1
Orangutan Pongo abelii VDAC3P2
Gibbon Nomascus leucogenys VDAC3P2
Green monkey Chlorocebus sabaeus VDAC3P2
Crab-eating macaque Macaca fascicularis VDAC3P2
Rhesus Macaca mulatta VDAC3P2
Baboon Papio anubis VDAC3P2
Golden snub-nosed monkey Rhinopithecus roxellana VDAC3P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>VDAC3P1
GGAGACAGGCCCTTGGGGGTGGAGGTCTTTGATTTCATAAGAACCTGAGAAAGATTTTTCTAAGATATGTGTAACACACCAACTTACTGTGACCTGGGAAAGGCTGCTGAGGATGTCTTCAACAAAGGATATGGCTTTGGCATGGGGAAGATAGACCTGAAAACCAAGTCCTGTAGTGCAGTGGAATTTTCTACTTCTGGTCATGCTTACACTGATACAGGGAAAGCATCAGGCAACCTAGAACCCGAATGTAAGGTCTGTAACTATGGACTTACCTTCACTCAAAAACGGAACACAGACAATACTCTTGGGACAGAAATCTCTTTGGAGAATAAGTTGGCTAAAGGGTTGAAACTGAGTCTTGATACCATATTGGTACCAAACACAGGAAAGAAGAGTGGGGAATTGAAGGCCTCCTATAAATGGGATTGTTTTAGTGTTGGCAGTAATGTTGATCTAGATTTTTCCGGACCAACCATCTATGGCTGGGCTGTGTTGGTCTTTGAAGGGTGGCTTGCCGGCTATCAGATGAGTTTTGACACAGCCAAATCCAAATTGTCACAGAATAATTTCGCCCTGGGTTACGAGGCTGCAGACTTCCAGCTGCACACACATGTGACCGATGGCACTGAATTTGGAGGTTCTATCTACCAGAAGGTTAATGGGATTGAAATGTCAATAAACCTTGCTTGGACGGCTGGAGTAACAACACCCATTTTGGCATTGCTACTAAGTACAAGCTGGATTGTAGAACTTCTCTCTCTGCTAAAGTAAATAATGCCAGCCTGATTGGACTGGGTTATACTCAGACCCTTCGACCCGGAGTCAAATTGACCCTTTATCAGCTTTAATCGATGGAAACAACTTCAGTGCAGGAGGTCACAAGGTTGGCTTGGCGTTTGAACTGCAAGCTTAATGTGGTTTGAGGAAAGCATCAGATTTGTCCCTGGAAGTGAAGAGAAATGAACCCACCATGTTTTGGCCCTACAATCCTTCTGTGAAATTTCAAAAGTGTGAACTTTTTACTCTTCCAAAAAATTGTAATCCTCCCCACACTGAAGTCTAGGGGTTGTGAGTCCCTCCTGAGGGGAGGCGCTGGAAAGCATGCCTGGAAGCTGTCCTGTTTGTGCCACGTTTCGGTTCAGTTCTGCAGTGTTATTAAATGTGTTCCTCGGCGACAGTGTGGTGTCATGTTAGAGGAGACGATCTGAACCTCCAGTTTGTACCTCGTGTCCTGCATGTTCACACCATTTTTTTCATGACTCTGTAATATATTGGTCTCTGTGCTATTGTGGAATCTTTGATTTTGCATCAGAGTAAAATAAAATAAACCCATCACATTTGGAACATAA
>NM_001135694.2
GCTCCGAAGCGCGCGACCGTGGCGCGACACGCCGGCGCACAGGCGCTCTCGGGGAGGGGCGGCGCGCAGGCGCGGCTGGGGGTGCGAGGCTGCGCAGGCGCGGACGGCGTTGGTTTGAAGACCTTCAGCGTTGCCCTGGCGGAGCAGAGACAGGCCCTCGGGGTGGAGGTCTTTGGTTTCATAAGAGCCTGAGAGAGATTTTTCTAAGATATGTGTAACACACCAACGTACTGTGACCTAGGAAAGGCTGCTAAGGATGTCTTCAACAAAGGATATGGCTTTGGCATGGTCAAGATAGACCTGAAAACCAAGTCTTGTAGTGGAGTGATGGAATTTTCTACTTCTGGTCATGCTTACACTGATACAGGGAAAGCATCAGGCAACCTAGAAACCAAATATAAGGTCTGTAACTATGGACTTACCTTCACCCAGAAATGGAACACAGACAATACTCTAGGGACAGAAATCTCTTGGGAGAATAAGTTGGCTGAAGGGTTGAAACTGACTCTTGATACCATATTTGTACCGAACACAGGAAAGAAGAGTGGGAAATTGAAGGCCTCCTATAAACGGGATTGTTTTAGTGTTGGCAGTAATGTTGATATAGATTTTTCTGGACCAACCATCTATGGCTGGGCTGTGTTGGCCTTCGAAGGGTGGCTTGCTGGCTATCAGATGAGTTTTGACACAGCCAAATCCAAACTGTCACAGAATAATTTCGCCCTGGGTTACAAGGCTGCGGACTTCCAGCTGCACACACATGTGAACGATGGCACTGAATTTGGAGGTTCTATCTACCAGAAGGTGAATGAGAAGATTGAAACATCCATAAACCTTGCTTGGACAGCTGGGAGTAACAACACCCGTTTTGGCATTGCTGCTAAGTACATGCTGGATTGTAGAACTTCTCTCTCTGCTAAAGTAAATAATGCCAGCCTGATTGGACTGGGTTATACTCAGACCCTTCGACCAGGAGTCAAATTGACTTTATCAGCTTTAATCGATGGGAAGAACTTCAGTGCAGGAGGTCACAAGGTTGGCTTGGGATTTGAACTGGAAGCTTAATGTGGTTTGAGGAAAGCATCAGATTTGTCCCTGGAAGTGAAGAGAAATGAACCCACTATGTTTTGGCCTTAAAATTCTTCTGTGAAATTTCAAAAGTGTGAACTTTTTATTCTTCCAAAGAATTGTAATCCTCCCCACACTGAAGTCTAGGGGTTGCGAATCCCTCCTGAGGGAGATGCTTGAAGGCATGCCTGGAAGTTGTCATGTTTGTGCCACGTTTCAGTTCAGTTCTGAAGTGTTATTAAATGTGTTCCTCAGCGACAGTGTAGCGTCATGTTAGAGGAGACGATCTGACCCACCAGTTTGTACATCACGTCCTGCATGTCCCACACCATTTTTTCATGACCTTGTAATATACTGGTCTCTGTGCTATAGTGGAATCTTTGGTTTTGCATCATAGTAAAATAAAATAAACCCATCACATTTGGAACATAACTGCTCATGTGACTTGCTGGTGATGGTTTTCTTACCTTGA

Publications

PMID - Link Title
No publications available for this retrocopy