Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJC19P7
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:52252133-52252857  UCSC
Coordinates (T2T) chr1:52133637-52134361  UCSC
Coordinates (hg19) chr1:52717805-52718529  UCSC
Strand -
Parental Sequence NM_145261.4
Parental seq. overlap 263 bp
Parental seq. overlap (%) 18%
Genomic Region Intragenic (ZFYVE9)
Retrocopy Summary DNAJC19P7, located on chr1:52252133-52252857, is a retrocopy of the parental gene DNAJC19. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJC19
Full Name DnaJ heat shock protein family (Hsp40) member C19
Also known as PAM18|TIM14|TIMM14
Coordinate chr3:180983709-180989838
Strand -
Gene summary The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJC19P2
Bonobo Pan paniscus LOC100974096P2
Gorilla Gorilla gorilla DNAJC19P2
Orangutan Pongo abelii DNAJC19P1
Gibbon Nomascus leucogenys DNAJC19P4
Green monkey Chlorocebus sabaeus DNAJC19P4
Crab-eating macaque Macaca fascicularis DNAJC19P1
Rhesus Macaca mulatta DNAJC19P1
Baboon Papio anubis DNAJC19P1
Golden snub-nosed monkey Rhinopithecus roxellana DNAJC19P6
Marmoset Callithrix jacchus DNAJC19P5
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJC19P7
aTTTTTCAAAGTCTACCAAAATCTGCCTTCAGTGGTGGCTATTACAGAGGTATGTTTGAACCCGAAACGACAAAATGGAAAGCAGCATTAATAGTAGCTGTAAGCACTACTGCCAATAAAGAGAAAATAAGAGGTGCTCATTGACAAATGATGCTCTTAAATCATCCACTCTCTGGTAAAGGTGTGTCATTGTTGGCCGCAACCTCTGGGCTGGGATGAGCCATGCTCCTGGTGCAGTAGGGGAGCCCAGCCATGGCCAGTACAGTGGTAGCAGTCGGACTGACCATTGCTGCTGCAGGATTTGCAGGCTGTTATGTTTTGCAACCCTTATATAAGGCATGTGGAACCTCAAGTAAAACAAATTTTTCg
>NM_145261.4
GTGTTGCGTAGGGCGCCTGTGCTTGAGGTTGGGGGTTGCGTCGCTCTCTGGTAAAGGCGTGCAGGTGTTGGCCGCGGCCTCTGAGCTGGGATGAGCCGTGCTCCCGGTGGAAGCAAGGGAGCCCAGCCGGAGCCATGGCCAGTACAGTGGTAGCAGTTGGACTGACCATTGCTGCTGCAGGATTTGCAGGCCGTTACGTTTTGCAAGCCATGAAGCATATGGAGCCTCAAGTAAAACAAGTTTTTCAAAGCCTACCAAAATCTGCCTTCAGTGGTGGCTATTATAGAGGTGGGTTTGAACCCAAAATGACAAAACGGGAAGCAGCATTAATACTAGGTGTAAGCCCTACTGCCAATAAAGGGAAAATAAGAGATGCTCATCGACGAATTATGCTTTTAAATCATCCTGACAAAGGAGGATCTCCTTATATAGCAGCCAAAATCAATGAAGCTAAAGATTTACTAGAAGGTCAAGCTAAAAAATGAAGTAAATGTATGATGAATTTTAAGTTCGTATTAGTTTATGTATATGAGTACTAAGTTTTTATAATAAAATGCCTCAGAGCTACAATTTTAAAAAATGATTTAGCACAAGCTAAATCTCAAAGCCTTGGTATAATTTTCTTGTTTAAATTTGGGGATTTTAAATCAGATTATAGTTTAGAATATTTGCGTATTAATTATGGGCAAGCACACACCTTCTGAATAGAAATATTGTTCATTACTCATTTAGCAGATAATTTGGGACCTATGTCTACTTTTCAAGGCAAAGTGAagatgacagtccttgctctcagggagcccccactttaatgggagactgataaactggtaattagactgtgataaatagtatgATGGAAATTAGCTTAAGCTGTTTAAGTAGGGACTCTTCTTATTCGGTGGAAAGGCTGTTCCAGGTACAGGCAACTGGCCTGGCAACTTGGATACTTGGAACCTTGTATTTAAAAGTGAATTTAACCACAACTGAGACCTAAGAAATTGACCTAGGGGTGTGTGTGTGTGTGTATTCTATGTACATATAAACCATTTTTATTTCATGCATTAAAAATAGTATGATAAAGATTTCAgagtacaggtctggtacaatcacagttcattgcagcctcaacctcctgggtttaagcagtcctcccgcctcagcctcccaaagtactgggattacaggcatgAGTATTTACATTGTATTCAGCTAGCCCCTTAAAGGTAATGACCATTTATAAATTATTCCTTCAGTTGGCTATTTCTTGACATAATCAAACTTCTGCAATTGTTATGATTAAGCTTAAACCCTGTTAGCAAAACTGAAAACTGAAATGTTCTCAATATCAACATATTTAATTTGGACTCTTTAGAATTTATACACTAATAAATTTAAATGATGTTTAAAGGCAAA

Publications

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