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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ANAPC10P1
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Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:52253564-52254383  UCSC
Coordinates (T2T) chr1:52135068-52135888  UCSC
Coordinates (hg19) chr1:52719236-52720055  UCSC
Strand +
Parental Sequence NM_014885.5
Parental seq. overlap 756 bp
Parental seq. overlap (%) 52.6%
Genomic Region Intragenic (ZFYVE9)
Retrocopy Summary ANAPC10P1, located on chr1:52253564-52254383, is a retrocopy of the parental gene ANAPC10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ANAPC10
Full Name anaphase promoting complex subunit 10
Also known as APC10|DOC1
Coordinate chr4:144967117-145098571
Strand -
Gene summary ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ANAPC10P1
Bonobo Pan paniscus ANAPC10P1
Gorilla Gorilla gorilla ANAPC10P1
Orangutan Pongo abelii ANAPC10P1
Gibbon Nomascus leucogenys ANAPC10P1
Green monkey Chlorocebus sabaeus ANAPC10P1
Crab-eating macaque Macaca fascicularis ANAPC10P1
Rhesus Macaca mulatta ANAPC10P1
Baboon Papio anubis ANAPC10P1
Golden snub-nosed monkey Rhinopithecus roxellana ANAPC10P1
Marmoset Callithrix jacchus ANAPC10P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.40.6
log10(TPM+1)

Related Sequence

>ANAPC10P1
GAGCTGCTGGAGATCCTGAGAACCTGAGTTTTGGCAAGCAGCCAGAATACTTAAAAAATGACCACACCAAACAAGGCACCTCCTGGTACTGACCCTGAGCAGTTGGAAAAGACTGGAACAGTACGGGAAATTGGGTCACAAGCTGTTTGGTCACTCTCATCTTGCAAACCAGGATTTGGAGTGGATCAGTTACGAGATGACAATCTAGAAACTTATTGGCAATCAGATGGCTCCCAGCCTCATTTAGTGAACATCCAATTCAGAAGAAAAACAACAGTTAAGACATTATATATTTATGCAGACTACAAATCTGATGAAAGCTATACTCCAAGCAAGATTTCAGCCAAAGTAGGAAATAATTTTCACAACCTTCAAGAAATTCGGCAACTTGAATTGGTGGAACCAAGTGGCTGGATTCATATTCCCTTAACTGATAATCATAGGAAGCCAACTTGGACGTTAATGATACAGATTGCTGTTCTAGCCAGTCATCAAAATGGAAAAGACACCCACCCATATGAGACAAATTAAAATATACACACTGGTAGAAGAGAGCGCCATTGGTAAATTTCCTAGATGTACAACTATAGATTTCATGATGTATTGTTCAATAAGGTGACTTTAAAATGATATGGAAGTCATTAAACGTATCTTTGTTTTATCCTGTCTTTAAATAGTATATCAGTTACCTTTATTGAAAAAAACATCAGTTATTTGCAACTTTATATATATTTAAAAATATTTTATTGTAATTTTGATAAATTTGGGTCATATTATCTTTAACATGTAATAAAGCTCACATATTTTACATTACT
>NM_014885.5
GTTCAACGCCGTTGGCGAAGCCAGCTGCTGGAGGTGCCGAGAATCTGAGTTTCGGCAAGCAGCCAGAATATTTTAAAAATGACTACACCAAACAAGACACCTCCTGGTGCTGACCCCAAGCAGTTGGAAAGGACTGGAACAGTACGGGAAATTGGGTCACAAGCTGTTTGGTCACTCTCATCTTGCAAACCAGGATTTGGAGTGGATCAGTTACGAGATGACAATCTAGAAACTTATTGGCAATCAGATGGTTCCCAGCCTCATTTAGTGAACATCCAATTCAGAAGAAAAACAACAGTGAAGACATTATGTATTTATGCAGACTACAAATCTGATGAAAGCTATACTCCAAGCAAGATCTCAGTCAGAGTAGGAAATAATTTTCACAACCTTCAAGAAATTCGGCAACTTGAGTTGGTGGAACCAAGTGGCTGGATTCATGTTCCCTTAACTGACAATCATAAGAAGCCAACTCGTACATTCATGATACAGATTGCTGTTCTAGCCAATCACCAGAATGGAAGAGACACCCATATGAGACAAATTAAAATATACACACCAGTAGAAGAGAGCTCCATTGGTAAATTTCCTAGATGTACAACTATAGATTTCATGATGTATCGTTCAATAAGGTGACTTTAAAATGAGACGAAAATCATTAAACGTATCTTTGTTTTATCCTGTATTTAAATAATATATCATGTACCTTTATTGAACAAGGCATCCGTTATATCTAATTTTGTATATGTTTAAAAATATTTTATTGTAACTTTGACAAATAAATTTGGGGTCATATTATCTTTATTTTCTTTAACATGTAATAAAGCTCACATATTTTACATTACTAAAAATGGATTTGAAGCCAATCATTTTATTTTCCCTTGTATCAAAAGAAAAGAGTTCCTTGTATCAAAAGAAAAGAGTTGAACTGAAAATTTCAGTATATACACAATTATAATAGCTAGGTGATTATTTCATTAGTGTTCATACATTAGAGTAATGGTTTATTGCATATTTGAGAACAAGACTGTGTTTTATCAATATATATCATCTTTAATAGGTCAAAATTACTATTTTTTCTACCCAGAGGAAGGTTATTCTTTTAATACTGGATCTTTTAAAAAACAGTGTCAAATAAGCTTAGTGTTAGGTTGTCTGATGAGAACCAATCTAATATGGGGAGTATAATTAATTGTCTCATATTCACCTTCACGGAATACTTACAGCCCTAGGGTTGTCTGTATCCTAATGATATTATGTAAAGATTGCCTGTATAATCTAGCAGTACTTATGGAAGAGTTCTAGCAGTACTTATGGAAGAGTTATTTTCAAATTTGTGTCTGACATTGTAGCATTCCCTGGGCAGTCATATATCCCATAAAATCGTAAAAGTATGTGAAATTTTTTATATATATTAAAAGATTTTAAAGAAA

Publications

PMID - Link Title
No publications available for this retrocopy