Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBBP8
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:29612503-29614439  UCSC
Coordinates (T2T) chr15:27403213-27405149  UCSC
Coordinates (hg19) chr15:29904707-29906643  UCSC
Strand +
Parental Sequence NM_178014.4_6
Parental seq. overlap 1190 bp
Parental seq. overlap (%) 47%
Genomic Region Intragenic (ENTREP2)
Retrocopy Summary TUBBP8, located on chr15:29612503-29614439, is a retrocopy of the parental gene TUBB2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBB2A
Full Name tubulin beta 2A class IIa
Also known as CDCBM5|TUBB|TUBB2
Coordinate chr6:3153666-3157544
Strand -
Gene summary Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBBP5
Bonobo Pan paniscus TUBBP5
Gorilla Gorilla gorilla TUBBP5
Orangutan Pongo abelii TUBBP5
Gibbon Nomascus leucogenys TUBBP1
Crab-eating macaque Macaca fascicularis TUBBP4
Rhesus Macaca mulatta TUBBP4
Baboon Papio anubis TUBBP4
Golden snub-nosed monkey Rhinopithecus roxellana TUBBP2
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBBP8
AAAAAAAAAAGACATATGTTCTTGCTCCATATATCCTTGAGGTGGGCAAAAAAATTAAATGTTAACCATGGAGGAAATTGTGCACATCCAGACAGGACACTGTGGCAGTCAGATCAGTGCCAAATTCTGGGAAGTTATCAGTGATGGTCATAGCATGGACCTACCAGTACCTGCCCAGGGACCACGATCTGTAGCTGGACCACATCTTGGTGTGCCACAGTGAAGGCACTGGGGACAAATATGTTCCTCCCACTATCCTGGTGGATCCAGAACCTGGGATCATGGACTCTGCTCAGATCCTTTgATCTGCAGACCAGACCACTTTGTTTTCGGTCAGTTTGGGGCAGGCAGCAGTACACAGTGGAGCTGAGCTGGTTGATTCATTCCTGGATATGTGCAGAAGGAAGCTGAGAGCTGTGACTGCCTTCAGGGCTTCCAGCTGACCCACTCACTGGGTGAGGGCACAGGCTCTGGAATGGGCACCCTCCTCCACAGCAAGATCCGAGAAGAGGATCCTGACCACATCATGAACACCTCCAGTGTAATGCCCTCACTCAAAGTGTTTGGCACTGTGGCTGAGCCCTGCAGTGCCCCCTCCCCATCCATCCACTGGTAGAGAACACTGATGAGACCTGCGGCACAGACATTGAGGCTCCTTATAATATTCGCTTCCGCACCCTCGAGCTGACCACACAAAACTATGAGGACCTGACCCACCTGTCTCAGCTAACATGCGTGGGGTCACCACCTTCCTCTGCTTCCCTCACCAGCTCAATTCGGACCTCTGCAAGCTAGCAGTCAATACAGTGTCCTTCCCACGCCTCCAGTTCTTCATGGCTACCTTTGCCCCTCTCACCAGTTGTGGAAGCCAGCTGTATAGGGCTCTCACCATGCCCAAACTCACCCAGCAGGTCTTTGATGCCAAGAACATGATGGCTGCCCCACCAGGACTGCCTTCTTCCATGAATATCCATCCATTCATGAAGGAAGTCAATGAGCAGATGCTCAGTGTGCAGAACAAGAGTCGCCAGCAGCTATTTCATGGAATGGATGCTAACAACGGTCAAGACAGCCATGTGGGACATCCTTCCTCATGGCCACAAGATGGCGGTCACGTTCGTCGGCAACAGCGCGGCCACCCAGAAGCTCTCCATGGCCTCTCAGGGCAGTTCCCTGCTGTATTGTGCGGGAAGGCTGTCCTCCACTGGTATGCAGGGGAGGGCATGAACGAGATGGAGTTCGCTGAGGCCGAGAACAACATGAATGACTTCATCTCTGAACATCGACAGTCTAGGACGCCGCCGCAGAAGAGGGAGAGGACTCAGTGAGGAAGCCCAGTGGGAGGCCTAAGGCAGAGCTCCCATCACCTCTGGCATCTCAATTCCTTCAGCCTTCTTCCTTGGCTGCCCCTTTCTTCTCCCTCAGTAGTCGTGTTTGCTGCCTTTACCTTGTTT
>NM_178014.4_6
CTCTCAGAACCTTCCTGCCGTCGCGTTTGCACCTCGCTGCTCCAGCCTCTGGGGCGCATTCCAACCTTCCAGCCTGCGACCTGCGGAGAAAAAAAATTACTTATTTTCTTGCCCCATACATACCTTGAGGCGAGCAAAAAAATTAAATTTTAACCATGAGGGAAATCGTGCACATCCAGGCTGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTCTGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGCGACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTTCCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCTTTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAACTGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTACGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGCGGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCTGATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTCGAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTATTGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCAACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTCCGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTCCCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAGTATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATGGCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTACTTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGCCTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGCATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGCGAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCTGAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCCGAAGAGGAGGCCTAAGGCAGAGCCCCCATCACCTCAGGCTTCTCAGTTCCCTTAGCCGTCTTACTCAACTGCCCCTTTCCTCTCCCTCAGAATTTGTGTTTGCTGCCtctatcttgttttttgttttttcttctggggggggtctagaacagtgcctggcacatagtaggcgctcaataaatacttgtttgttgaatgTCTCCTCTCTCTTTCCACTCTGGGAAACCTAGGTTTCTGCCATTCTGGGTGACCCTGTATTTCTTTCTGGTGCCCATTCCATTTGTCCAGTTAATACTTCCTCTTAAAAATCTCCAAGAAGCTGGGTCTCCAGATCCCATTTAGAACCAACCAGGTGCTGAAAACACATGTAGATAATGGCCATCATCCTAAGCCCAAAGTAGAAAATGGTAGAAGGTAGTGGGTAGAAGTCACTATATAAGGAAGGGGATGGGATTTTCCATTCTAAAAGTTTTGGAGAGGGAAATCCAGGCTATTAAAGTCACTAAATTTCTAAGTATGTCCATTTCCCATCTCAGCTTCAAGGGAGGTGTCAGCAGTATTATCTCCACTTTCAATCTCCCTCCAAGCTCTACTCTGGAGGAGTCTGTCCCACTCTGTCAAGTGGAATCCTTCCCTTTCCAACTCTACCTCCCTCACTCAGCTCCTTTCCCCTGATCAGAGAAAGGGATCAAGGGGGTTGGGAGGGGGGAAAGAGACCAGCCTTGGTCCCTAAGCCTCCAGAAACGTCTTCTTAATCCCCACCTTTTCTTACTCCCAAAAAAGAATGAACACCCCTGACTCTGGAATGGTGTATACTGCCACATCAGTGTTTGAGTCAGTCCCCAGAGGAGAGGGGAACCCTCCTCCATCTTTTTTGCAACATCTCATTTCTTCCTTTTGCTGTTGCTTCCCCCCTCACACACTTGGTTTTGTTCTATCCTACATTTGAGATTTCTATTTTGTGTTGAACTTGCTGCTTTTTTTCATATTGAAAAGATGACATCGCCCCAAGAGCCAAAAATAAATGGGAATTGAAAAAA

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