Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COX7BP4
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:54089792-54090220  UCSC
Coordinates (T2T) chr1:53972695-53973123  UCSC
Coordinates (hg19) chr1:54555465-54555893  UCSC
Strand +
Parental Sequence NM_001866.3
Parental seq. overlap 397 bp
Parental seq. overlap (%) 16.2%
Genomic Region Intragenic (TCEANC2)
Retrocopy Summary COX7BP4, located on chr1:54089792-54090220, is a retrocopy of the parental gene COX7B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COX7B
Full Name cytochrome c oxidase subunit 7B
Also known as APLCC|LSDMCA2
Coordinate chrX:77899468-77907376
Strand +
Gene summary Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COX7BP3
Bonobo Pan paniscus LOC100986707P3
Gorilla Gorilla gorilla LOC101147253P2
Orangutan Pongo abelii COX7BP1
Gibbon Nomascus leucogenys LOC100602515P1
Green monkey Chlorocebus sabaeus LOC103232235P5
Crab-eating macaque Macaca fascicularis LOC102124180P1
Rhesus Macaca mulatta COX7BP1
Baboon Papio anubis LOC101013709P3
Golden snub-nosed monkey Rhinopithecus roxellana LOC104669550P4
Marmoset Callithrix jacchus LOC100390732P4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COX7BP4
GACCTGAAGTGAATTTGCACCAAAGCAGCAGCTGCATTGCCACAGTTCTGTCTTCACCTTCACCATGTTCCTCTTGGTCAAAAACGCACCAAGTCGTCTCCAAGTTTGAAGCATTCAGCAAACAATGGCAAGGCAGAGCCACCGGAAACGTACACCTGATTTTCATGATAAATATGGTAGTGCTGTATTAGCTAGTGGAACCACTTTCTGTATTGCTATATGGACATAGGTAGCAACACAAATCAGAATAGAATGGAACCTGTCCCCTGTTGGCAGGGTCACCCCAAAGGAATGGAGAGATCAGTAATCATTCCAGCTGGTGTAATAATGAATTGTTTAAAAAACAGCTCGTAGTTGATGCCAAGTTAAAGCACTGTGTACCCATTAAGATATGGCATTATTGAAGAAATAAAGTACATTTGAAACCTT
>NM_001866.3
GTTTTTCAGCTCACTTCAAGGGTACCTGAAGCGAATTGGCACCAAAGCAGCAGCTGTATTGCCGCAGTTCTAGCTTCACCTTCACGATGTTTCCCTTGGTCAAAAGCGCACTAAATCGTCTCCAAGTTCGAAGCATTCAGCAAACAATGGCAAGGCAGAGCCACCAGAAACGTACACCTGATTTTCATGACAAATACGGTAATGCTGTATTAGCTAGTGGAGCCACTTTCTGTATTGTTACATGGACATATGTAGCAACACAAGTCGGAATAGAATGGAACCTGTCCCCTGTTGGCAGAGTTACCCCAAAGGAATGGAGGAATCAGTAATCATCCCAGCTGGTGTAATAATGAATTGTTTAAAAAACAGCTCATAATTGATGCCAAATTAAAGCACTGTGTACCCATTAAGATATGGCATTATTGAAGAAATAAAGTACATTTGAAACCTTCATTGTAGGTTTTGTTTCTTTGTAAATGAAACTAAGCTTGATCACTTTAGCCTTTATGTTAATATTAAAGTCAAATGCTGTGCAGCTTCTTAAATAGGtttttttttttttttttttttttttttgggacgaagtctcactttgtcccccaggctggagtgcagtggcaccatctcagctcactgcgacctctgcctcctgagttcaagtgattctcctgtctcagcctcccgagtagccagaactacaggcacatgccatgacgcccagctaattttttttttttttgagacggagtctcactctgttgcccaggctggaatgcaatggcgtgatctcggctcctgcaacctccgcctcccgggttcaagcgattctcctgtctcagccttccaagtagctgggattacaggtgcacgccaccaggcccggctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcgagctcctgatctcgtgatccacccaccttggtctcccaaagtgctgggattacaggtgtgagccaccgtgcccggcaatttttgtatttttagtagagacagggtttcaccatattggtcaggctggtttcaaactcacgacctcaggtgatccgcctgccttggcctcccaaagtggtaggattacaggcgtgagccacggcacccagccCTTAAATGGCTTTTATGAGGTAATGTGAAAGGAAAATTTGCCTTTGACCTGGAAGTCAACTTTATAGTAAGCTGAAATTATAAATAACTGATCATGGAACTATTGCAGATCACCTTTGAGCCAAAAATTTGGCCTGGATTTTGGTTATGCCTACTACTATGTGCCTCTCATTTGTATTTATACCTGGAATTGGCATTATTAACTCCTTTTCACTCCTGCCTAGAAAACTTAAAGTGTCACCAGACCCAAGGGCGGAGTGGTCCTATAAAACAAACTCGTAGCCTGTCTGAAGACTAGCTACTAGCTCCTTGGCTGTTTTGGCATATTCATCTTGATTATAGCTCTTGGTCTTTCATCATATTAGGGATGTTTATGATGTTATTAAAGAAAATCTTGTCAAATGCAGTCTGTTCCTAGTTATCTACTATCAGTCACCTGTTGTATAATTATAACAATGTTTGGATTTGTGGATTATTATTTTAGTATATAACATTGGATTTTATGTATGTTACCTGAAGAAGAGCAATATCTGTACCACATAtttctttgtttttcttttttgagatgaagtctcactctgttgcccaggctggagtgcagtggtgtgatcttgacacactgcaacctttgcctcccggattcaagtgattctcctgtctcagcctccctagtaactggaattacaggcgcctgccaccatgcctggctaatttttgtatttttagtagagatggggtttcaccatgttggccaacctggtcttgaactcctgacctcaggcgatccacccacctcagcctcccaaagtgctaggcttacaggcatgagacaccgcgcccggcTTATATATCATTACTTTCTTGGCTGAGAGCTGTAGTCTGTGGTAGttgttttgttttgttttttgttttttttttgtagttttcttGATCGTGATCAATTAAGCAGAAAGTAGAATTTCAGTCAGGTAACCTGTCTATATTAGCTAAATTATCTTTTGCTTATTACATAGAGTGCTAGAAGTATGCTGTCATGGCATATGTCCTAGTTTCTCATCAAATGGACCAAAGTCAGTGATTTTATTTGAAGAGGAAAAATTGAACGTCATTGTAAATTAAGTTGCAAGTTTAGTAACCATATTGTACCACTGTTTGATAAATTTGAACGCTTTATGGTATTTCATATTTAGAATGTTCAAAATAGTACTGAAGTATTCAAATACATACAACCCTGAGCGATATTGAAGTAAAATAAACATGTATTTAAGGAAGTGTCAACCTTCAATTATATAC

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