Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ISCA1P4
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:40947040-40948875  UCSC
Coordinates (T2T) chr15:38752994-38754821  UCSC
Coordinates (hg19) chr15:41239238-41241073  UCSC
Strand -
Parental Sequence NM_030940.4
Parental seq. overlap 776 bp
Parental seq. overlap (%) 32.3%
Genomic Region Intragenic (CHAC1)
Retrocopy Summary ISCA1P4, located on chr15:40947040-40948875, is a retrocopy of the parental gene ISCA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ISCA1
Full Name iron-sulfur cluster assembly 1
Also known as HBLD2|ISA1|MMDS5|hIscA
Coordinate chr9:86264546-86282538
Strand -
Gene summary ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ISCA1P4
Bonobo Pan paniscus ISCA1P4
Gorilla Gorilla gorilla ISCA1P5
Orangutan Pongo abelii ISCA1P4
Gibbon Nomascus leucogenys ISCA1P3
Green monkey Chlorocebus sabaeus ISCA1P8
Crab-eating macaque Macaca fascicularis ISCA1P2
Rhesus Macaca mulatta ISCA1P2
Baboon Papio anubis ISCA1P3
Golden snub-nosed monkey Rhinopithecus roxellana ISCA1P1
Marmoset Callithrix jacchus ISCA1P6
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ISCA1P4
TTTATTTTGAATAGGAAAAATATTTTAAAACCCTTTTATGTGAGTTACTTTCTTGTTTCTTTAACCTTTGAAACAATGGTTTGTAGCAGAGAAGACATTGTAGCAACCTAGAATTATGCTTTTGGAATGTGGTCCTATAGATGACACATGTGCTCTGCCCTCCAAGGCAATCAGTGAAGGCAAATGGTCTGGCTTGTCTGGTCAACATTTTGATATAATTTCTTTACAGTTTTATGGAGATCAATCAAAAATTTCATTGTCAGATGCCTCACTGCATACCCTTTAATAGTACCGGGCAAAGATTTCTTTGAACTATAGTACAGAATAGTTCTGAGTGATGGTATCAAAAGGTGAGAAAGACTTCATCCATCTCTTTTTTAATCCATTTCTTTTGCCACCCTATATGTCTGCTCAAAGATGGGATCTCAAGCTGACTTTTAAGAGGTCGGCTTCCTTAGTCCGGAGGACTGTCCGGACTGTGAGCAAGAGGAAGCTACAGCCCACGAGGGCCACCCGCAGCCTGACACCTTCAGCAGTAAACAAGATAAAATAACTTCTTCAAGATAAGCCTGAGTATTAGGTGTAAAAGTTGGTGTCCGAACCAGGGCCTGTAATGACCTTTCTTATAGTCTAGAATAAACGAAGACAAGGGAGATTTCGATGAAGAAGTCATTCAAGATGGAGTCAGAGTGTTCATCGAAAAGAAAGCACAACTAACACTTTTAGGAACAGAAAGACCATGCTGAAGACAAACTATCCAGTGAGTTTGTGTTCAATAACCCAAACATCAAAGGAACATGTGGCCGTGGAGAAAGCTTTACTATTTGACATCTCAGGACGCCTCTGACCATAAGCTCTGGGAAAGCTCCTGGAAGCCCTGGGGCTCACAAATAAATCATATGATTGTCACGTGCTTAATGTGTGCCTGCCTTGTGAGGAAAATATAAGTGATGCATTTTGGAAATGTGCTAGATTCCAGAAGAAATGATATTTGTAGTCTCTGTAAGGGACAGAAAATGAGAAGCCATCACTCTCTTTGGACCATTTAACTCTCTTGCATCCTTTGTTTTAGAACCAGTTTCATTAAAGTTGTCTTCCTGGGCCCCTGTTTCTCCATGTCCTGAGCAGTGTGCACTCATTAGGTCTCTGTTGGATGGCCTGAACGTGCATCTCCCTCGACATTTCTCCCAACCAGATTGGGGACTCCTACAATTCAGTGACAGGACGTCCTGACTGCTGGTAGTAACATGGTGGTGCCTTGTTTTTCCACCCAAACTTAACACAATCTGTTTACATTTTTATCAAAACt
>NM_030940.4
AATGCGCCCGCCGTGTCCATGGAGAGAAGCTGAGGCGGCCGACCTTCGGCCCGAGGCACCGGGGCGCCGGGACGGCGAAGATGTCGGCTTCCTTAGTCCGGGCAACTGTCCGGGCTGTGAGCAAGAGGAAGCTGCAGCCCACCCGGGCAGCCCTCACCCTGACACCTTCAGCAGTAAACAAGATAAAACAACTTCTTAAAGATAAGCCTGAGCATGTAGGTGTAAAAGTTGGTGTCCGAACCAGGGGCTGTAATGGCCTTTCTTATACTCTAGAATATACAAAGACAAAAGGAGATTCTGATGAAGAAGTTATTCAAGATGGAGTCAGAGTATTCATCGAAAAGAAAGCACAGCTAACACTTTTAGGAACAGAAATGGACTATGTTGAAGACAAATTATCCAGTGAGTTTGTGTTCAATAACCCAAACATCAAAGGGACTTGTGGCTGTGGAGAAAGCTTTAATATTTGAAATCTCAGGACTCTTCTGGCCGTAGGTTCCAGGAAAGCTCGTGGAAGCTTTGGGGCTCACTGCAGAAATCATGTGACTGTCACGTGCTGGAAAATAAAGTGATACATCTTGAAAATGAATCCAGTGTGTTGGATTCCAGAAGAAATGATATTTATATTCTCTATAGGGGACAGAAAATGAGAAGCCATCACTCTTTTTGGATCATTTAGGTCTCTTGTATCCTTTGTTTTAGAACCAGTTTCATTAAAGTTGCCTTCCTGGGCACCTGTTTATCCATTTCCTGAACTGTGTGCACTCCTTAGATCGCTATTGATGGCTTGATCATCCCTCAGCATTTCTCCCAACCAGATCGGTGACTCCTAAAATCTGAGACAGGACATCGTGACTGCTGGTAGTAATATGGTGGTGCATTGTTTTTTCCACCCAAACTTAACATAGCCTTTTTATACATTTTTATGAAAAATTTCATTGTCAGCTGCCTCACTGCATACTCTTTAATAGTACCAGGCAAAGATTTTCTTCAACTATAGTACAGATTAGTTCTGAGTGATGGTATCAAAAGGTGAGAAAGACGTCATCCGCCTTTTTTTAATCCATTTCTTTTGCCACCCTATATGTCTGTTCAGAGATGGGCTCTCAAGCTGACTTTGATTCTTTTAGTTGAGAAGTCTCTTAAAGCCATCTAGCCCACCTCCATCAATTCCCTATGTGAGGAAGCAAAACCCCAGGGAAGCCAAAGGGCTCCTGTCCACCCTGACACCACAGGCCGGGGGAGAGTAGGGACTCTACCCCCCTCTCCCCTTGTAGGTGACACATGCTCTGCCCTCTGAGGCAGTCAGCGAAGGCAAATGGTCTGACTTCTTTATGTGGTCAACATTTTGATAGAATTTCTTTATAATTTGATAGAGATTATATTATTTTTATTTTATTTTGAGTGGGAAGAATTTTAAAACCTTTTTATGTCAATTACCATCTTGTTTCTTTCACCTTTGAAACAATGGTTTGTAGCAGAGATGACATTGTAGCAACCCAGAATTATGCTTTTGGAATGTGGTCCTCACTGTACAGGAGAATGTGTAATCTTTTGTTAAAATTCCCAGTGTGCATACATTTTCTGGTTCCTCGGTCCAGTTGCTAAAGTTCTTAGTATTTTAGCCTAACATATTTATCACCAACTTTTCTTTAAAAGTGTTCCTTTTGTCACTTAGTTACTGATTTTCCTGGGTTTGACATAAGTATTCTATGAGATGATATATATGCTTTTTTTGAAAGCTGATTCTCATGAATTCAAGTAGCTGAGTTCCTTTATGTTTCGTTTATTCACTAAAGTAGCTGACACAAAACACACCAAAACCTAGAGCGGTAGTTTTATGTAAATGCTCATGAGTTTGTATCAATAATATAATTGTTGATCCACTTATAATTCGTGCAACACTGTATGTATGTAGAGATTGAGTTGTCAATTAAAAAAAATGTGGCCTCTTTGTGATCATAAAA

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