Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PIN4P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:43875829-43876272  UCSC
Coordinates (T2T) chr15:41683188-41683631  UCSC
Coordinates (hg19) chr15:44168027-44168470  UCSC
Strand -
Parental Sequence NM_006223.4
Parental seq. overlap 399 bp
Parental seq. overlap (%) 32.2%
Genomic Region Intragenic (FRMD5)
Retrocopy Summary PIN4P1, located on chr15:43875829-43876272, is a retrocopy of the parental gene PIN4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PIN4
Full Name peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Also known as EPVH|PAR14|PAR17
Coordinate chrX:72181676-72263964
Strand +
Gene summary This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PIN4P4
Bonobo Pan paniscus PIN4P4
Gorilla Gorilla gorilla PIN4P4
Orangutan Pongo abelii PIN4P5
Gibbon Nomascus leucogenys PIN4P3
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PIN4P1
GTTCAGAGTTCAACAACAAGCTTCCAAGATGCCGCCCAAAGGAAAAAGTGGTTCTGGAAAAGCGGGGAAAGGGGGTGCAGCCTCTGGGAGTGACAGTGCTGACAAGAAGGCTCAAGGTCCCAAAGGTGGTGGCAATGCAGTAAAGGTCAGACACATTCTATGGGAAAAACATGGCAAAATCATGGAAGCCATGGAAAAGTTAAAGTCTGGGATGAGATTCAATGAAGTGGCCACACAATATAGTGAAGATAAAGCCAGGCAAGGGGGCGTCTTGGGTTGGATGACCAGAGGGTCCATGGTGGGACCATTTCAAGAAGCAGCATTTGCCTTGCCTATAAGTGTGATGGATAAGCCTGTGTTTACAGACCCAGCAGTTAAGACAAAATTTGGATATCATATTATTATGGTTGa
>NM_006223.4
GGTTCAGCGTTCAACAACAAGCTTCCAAGATGCCGCCCAAAGGAAAAAGTGGTTCTGGAAAAGCGGGGAAAGGGGGAGCAGCCTCTGGGAGTGACAGTGCTGACAAGAAGGCTCAAGGTCCCAAAGGTGGTGGCAATGCAGTAAAGGTCAGACACATTCTATGTGAAAAACATGGCAAAATCATGGAAGCCATGGAAAAGTTAAAGTCTGGGATGAGATTCAATGAAGTGGCCGCACAGTATAGTGAAGATAAAGCCAGGCAAGGGGGTGACTTGGGTTGGATGACCAGAGGGTCCATGGTGGGACCATTTCAAGAAGCAGCATTTGCCTTGCCTGTAAGTGGGATGGATAAGCCTGTGTTTACAGACCCACCGGTTAAGACAAAATTTGGATATCATATTATTATGGTCGAAGGAAGAAAATAAAATCATATGAAAGACTGAATAAGTTTTATACATTTTGTTTCTTTAAAAGGTATTACATATTCTTTTGAGCTGGAGCTGCAAGGAAATACAAAAATTTTTAAAAAGAAAAGATATTGGATGCTCCTTGTATTCTGTGAAAGCTCTAAGTATGGGTTTGTAGGTGTAAGAGAGGGTGGGGCTAAGTGAATGTCAACTGTAGTAGGTATTCAGTCAGTCTTTCTCAAAGAGAAGTCAAGCAGACTCCCTTTAACCTGTATTCTCTTTCCTCCCAGAACTATATCTGACTCTCAGTCTGTCCCATAAATTAATTCAGAAACCATCTTCAGGGGAAGCAGATATCAACTCACACTATTCACACAACTGAAAATATTGGGCATCAAATAGATTAGTGTGTGAGAATCATAAAATAAGTTCCTAGACAACATTTGTTTTACATGTTAGTCAACTCTGATCTTCCAGGACAGGTGGTATTAGCTCCACTGTCTTAACATAGTACGTGGCACGTTATGCCTTTCAGTGTTAACTCCTTTCTTTTTAAATAAATGTTTATTGGAGGAAAAAAGCACTCAGTTGTTCCATGAGTTGTTTTGTACTAGACTAACCGAGTGCTGGTTAAAGGGAGGGATGTCAGCATAAAAATGTCATTCCCTCATCTTCAGTGTATGGGTTACATTAAGACTGTCCTTTCCAGGGCCAATGTTCTGTGCATCTAAATTTTTAAAATTTAAAATGCCATATTTATGACATATAAAAAAGTATAAAGATTACTAATATAAATACTATACTGCTTCAAAAATAAAACTTTGCCAACACA

Publications

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