Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AZI2P2
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:44919262-44920960  UCSC
Coordinates (T2T) chr15:42727268-42728966  UCSC
Coordinates (hg19) chr15:45211460-45213158  UCSC
Strand +
Parental Sequence NM_022461.5
Parental seq. overlap 1211 bp
Parental seq. overlap (%) 27.4%
Genomic Region Intergenic
Retrocopy Summary AZI2P2, located on chr15:44919262-44920960, is a retrocopy of the parental gene AZI2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AZI2
Full Name 5-azacytidine induced 2
Also known as AZ2|NAP1|TILP
Coordinate chr3:28321047-28349278
Strand -
Gene summary AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AZI2P2
Bonobo Pan paniscus AZI2P2
Gorilla Gorilla gorilla AZI2P2
Orangutan Pongo abelii AZI2P1
Gibbon Nomascus leucogenys AZI2P1
Crab-eating macaque Macaca fascicularis AZI2P1
Rhesus Macaca mulatta AZI2P1
Marmoset Callithrix jacchus AZI2P1
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AZI2P2
GGAAATCGGAACCCGTGGTGATCCCTGGCAACCCGATCTGTTTTTGGCTGTTTCTAAACATTAAGGAATGGAAACTCCATGGCGGCCCTAAGTAGCCTGGTTTCAGGCTCTCATGGATGCACTGATAGAAGGTGATACCTGTATGCTAAATTATGAGAAAACCACAGCAACTCCAATTTCAACATATTGAGGAGATGCTTCTGTTGCTTCCCAATTTGCCCATATGAAGACATCAAAAAAGGACTTAAGGATTCAGAGAAAGAGAAATCTTATGATAAAGAAAAGAATTAGATTTTTGGAAGAAAAGCTTATAGGAGCTCAATTAGATGAAGAAACAAGTTTTGTGGAATAGCAACAAGTAAATAAGGCCTATTATGCATATTGAAAGATTTGTaGATTTGCATTGATAGACATGATTTAAAGAGCAAATTGGATAAAATGAGTAAACACAACTCTGAATCTTTAAAAGTATTGAATAAACAGATGCAATCTAAAGAAGTAGAACTCTAGCTAAGGACAGAGGTGGAAACTCAGCTGGTGATGAGGAATTTCAATCCACCTTCATCAAACTGGGAGGTGGAAATGTTAAGCTGTAACCTGAAGATCCAAGGTTTGGAACAAGAGCTGATGAGGAAAGAATATAACGATCTCAAAATAGAACTACTCAAAAACCAAACAAACCTATCTGTATGAGGAAGACAATCTTGAAGAGCAGAGATCTCTGAAGAGTAAGAACTTCAAGTGATAATACACAGAATGTATACTGGCAACTGAAGAGATAAATGTCTAATTTATATCTGGTGACTCAAGTGCTAGCTGAACTATTAAGAAAACTGGAAACCCCAACTGCAATCAAGAAAGCCTGCACCTCAGTAAGATGCATTGAAGACCCTTGGAAAGACAGCACAAAACTGCACATGATGAATTTTACTGCAACATACACAAGACATCCCCTTCCCTGACCAAATGGCAAAGTTCTTTTTTATACTACATCTTCCCCTTTACCAGGAGATATAAAGGTTTTATCAGAGAAAGCAGTCCTCCAATCACGGACAGATAATGAGAGAGCCATTCCTAATGAGGGCACACACTCTTATGGCAGAAATTCTCTGGAAGATCATTTTGAGTATTCCCAATCCCTCCTGACTCAAGTGAGACAGCATTTAGGAAAATTAAAAGTAAAATTTTGCCTTTTAACAAATGTGCCACTACTGCATTACTTGGATCAACATAGTCAAAATTTCCTTTATAAGACTTAACTCTGAAGAGATTCATCATTTGATCAAAAGGACACTGTCTCTCAGTGGTTCTCTCAAGAAATTCTTAACAAACTAAACGTAGATTTTGATTAAAATTTTGTAGAGTTCTTTAGTATATGCATTTGAACATACTGTA
>NM_022461.5
CTCCTTCCAGAACGTCCCGGGCTCCTGCCGAGTCAGAAGAAATGGGACTCCCTCCGCGACGTGCCCGGAGCAGCTCCCTTCGCTGTGGAAGCGGCGGTGTCTTCGAAGAAACCGGAAGCCCGTGGTGACCCCTGGCGACCCGGTTTGTTTTCGGTCCGTTTCCAAACACTAAGGAATCGAAACTCGGCGGCCTTGGGGGCGGCCCTACGTAGCCTGGCTTCTGGTTGTCATGGATGCACTGGTAGAAGATGATATCTGTATTCTGAATCATGAAAAAGCCCATAAGAGAGATACAGTGACTCCAGTTTCAATATATTCAGGAGATGAATCTGTTGCTTCCCATTTTGCTCTTGTCACTGCATATGAAGACATCAAAAAACGACTTAAGGATTCAGAGAAAGAGAACTCTTTGTTAAAGAAGAGAATAAGATTTTTGGAAGAAAAGCTAATAGCTCGATTTGAAGAAGAAACAAGTTCCGTGGGACGAGAACAAGTAAATAAGGCCTATCATGCATATCGAGAGGTTTGCATTGATAGAGATAATTTGAAGAGCAAACTGGACAAAATGAATAAAGACAACTCTGAATCTTTGAAAGTATTGAATGAGCAGCTACAATCTAAAGAAGTAGAACTCCTCCAGCTGAGGACAGAGGTGGAAACTCAGCAGGTGATGAGGAATTTAAATCCACCTTCATCAAACTGGGAGGTGGAAAAGTTGAGCTGTGACCTGAAGATCCATGGTTTGGAACAAGAGCTGGAACTGATGAGGAAAGAATGTAGCGATCTCAAAATAGAACTACAGAAAGCCAAACAAACGGATCCATATCAGGAAGACAATCTGAAGAGCAGAGATCTCCAAAAACTAAGCATTTCAAGTGATAATATGCAGCATGCATACTGGGAACTGAAGAGAGAAATGTCTAATTTACATCTGGTGACTCAAGTACAAGCTGAACTACTAAGAAAACTGAAAACCTCAACTGCAATCAAGAAAGCCTGTGCCCCTGTAGGATGCAGTGAAGACCTTGGAAGAGACAGCACAAAACTGCACTTGATGAATTTTACTGCAACATACACAAGACATCCCCCTCTCTTACCAAATGGCAAAGCTCTTTGTCATACCACATCTTCCCCTTTACCAGGAGATGTAAAGGTTTTATCAGAGAAAGCAATCCTCCAATCATGGACAGACAATGAGAGATCCATTCCTAATGATGGTACATGCTTTCAGGAACACAGTTCTTATGGCAGAAATTCTCTGGAAGACAATTCCTGGGTATTTCCAAGTCCTCCTAAATCAAGTGAGACAGCATTTGGGGAAACTAAAACTAAAACTTTGCCTTTACCCAACCTTCCACCACTGCATTACTTGGATCAACATAATCAGAACTGCCTTTATAAGAATTAATTTGGAAGAGATTCACGATTTCACCATGAGGACACTTATCTCTTTCAGTGGTCCTCCCAAGAAATTATTTAACAAACTGAAAGGAGATTTTGATTAAAATTTTGCAGAGGTCTTCAGTATCTATATTTGAACACACTGTACAATAGTACAAAAACCAACATAGTTGGTTTTCTAGTATGAAAGAGCACCCTCTAGCTCCATATTCTAAGAATCTGAAATATGCTACTATACTAATTAATAAGTAAACTTAAGGTGTTTAAAAAACTCTGCCTTCTATATTAATTGTAAAATTTTGCCTCTCAGAAGAATGGAATTGGAGATTGTAGACGTGGTTTTACAAAATGTGAAATGTCTAAATATCTGTTCATAAAAATAAAAGGAAAACATGTTTCTTCAAATTGCATAATGGAACAAATGGCAATGTGAGTAGGTTACATTTCTGTTGTTATAATGCGTAAAGATATTGAAAATATAATGAAATAAAAGCATCTTAGGTTATACCATCTTTATATGCTATTGCGTTTCAATATTTAAGATTTAAAGTGATTTTTTGGTCACAGTGTTTTGTTGATAAAATTTTTTTAGAATTGAAGTTTGAATTCTAAGACTTGAAACAACCTGATCACTGAAGCCAACTTTGTCCCAGCACATTCCTTAAGTCCTAATTGGGaaaaaaaaaaaaaaaaaTGAAATAGTTGAAAAACTCTGGGGTGTAAACAAATGATTGTAACCCTACACACTATTCAATAAGTAGTAGAAGGAGCATCACACAGATTTCAGTCTAATCTGCCCTTCTGTGGGCCATAATATAAACATAAATGTGTGTAATGATAAAAAGTCATTTTCTTCAAAGAGACTACAGCTAGCTGCACATTGTGTAGAGCAGCTTCTAAATTGTTAGACTTTGTGTTGAAATGTAATATTCTATTTATTGAGAAAGTGATTTAAAATTATTATTTTTAATCATAGAAATCAGGGTTTGGGCTGTATTGATATTGTCGATCATGAAATGTCCACACTTATTCTAAGTGGCCAATTATTTGGAAATAAAGAAGGAAATAAAGATGGCTTCACATGGAAATTTAAGTTCTTTCAGGGTGGAGATTTACTTGGTTCATACACCTTTTGCCTGAATTAAAGTATTTCATGTAGGAGGACTTTTATCCTTTTTGATAGACAGTTTCATATATCTTGAACTCAATATCTCAGATCTCTTCTACTGTATTACTGAATAGCATACATACATAGACAATGTTCGCCATTCACTAGATATTTTTTTCTATTATCTTACACTTATTCAAGCTTGTCTGTGATTAATGGAATTGGTGTCAGATGCTGGAATTTATTCTGACCAATGAACACAGCTGACTCAGGGGAGTACAATCTCCTGCCAAGTAATAGAACCAAACCCAATATGCATAAAAGAAATACAATACTCCAGGCTTTAGCTGAAGGAAGCAACTACCTGTGTAATAACAAAGCAGCAAAAACTATTTCTCATGTGGCTGCATAGGCTGTATATTATATCTGATCTCTAATGTAGCTTACTGGTTTGCCTTTTTTAAAACCAAAATTGGAAATTTTCCTTTGTAAAGAAAAAAAGTCTTATGAGATAATTGCTTGATTAATGTTTTGAACAATACCAAGAAATTGTTTAATTAAAATAAATATTTTTGTTTGAAATTGAAGTGGATGTGAAATATTGTCCTTGCCTATAGATCTCAAAATCTAGTACTAATTGTTGGTTGTTAATATGATTCATACAATAGACATTTGTTAAACCAGCTTTTGAGTGGAGAAAATTATTTTCCATTTAAACAGTACAGTGATGATAGCTATCAAACAGGTATACTAAAAAGTCAGTGACTGTGACAGTTTAAAGTGTTAGACAAATGATGTATAAGGTTCTTTAGTAAGGAAAGATTAGCCAAAAATTTTTTACCCAGCTAGAAGCTTTTAAATCTACACTTGATATCTCTGTTCTAGGTAAAATTCAAACAACCAAAAAACAGTGGCCCATCTGTAGCTTATGAATCTATTTAAAATTGAATATTTTATGTTGACTTCTTTCATACTAGCTGAAACTTGCTCTAAAGAGCTTCCTTTGGAATCTTTAGATTTCTTTTTATAAGGTTCAATTCAGTACATCCATAAATCGACAGAATGAAGAAAACATAACAAAAAGCCACCTATTCCTTCCTCTTGCTCCCTTATTAGCTAAAGTAAAATTTACATCTGTAAGACTTACTGAGTTGCTGCCAAAATGGAACTGAATTCTTAAAAGCAGGAACATGCCTATGTGAAACATTAGAAAACCAAAATAAATGGGAAAATTCAGACTTGAAGAGCTGAATCATGTGACAACAAAGTACTGATCTTAATTCAGAAAGGCTACTTGGAGAAGGTGTATCTTAAGGGGTAAAAAACCTGTGGGTTACCACATATTAACAGGGAATAATATCAACAGAGGCACCCATAAGCAAGCAAGACACAACTGAGACAGATGTACCAGGTGAAAAAAATCTTCAGTATGGATACACATGGGTATTCTGAAGGCTACAATGAATGGTTTAGTCTTTGACATAAGGAGGATGAACATATTATTTATACTGTGTAATCTAATCTGGCTTCTATGGGGAAAGCAACATGTACATAAGTGAATTTTCTACATGAAGTGGGCTACTTCTGATTTTAATCAAAGCTATAAAATAGATTGTATATTTCACTAGCTTCTTAAAGTAACTCTTCCATTTTCATTTATCTCTAAAAACAGTTAACTTCCTGTGCTCTAGGAAATGCACCAATACCAAAGGTCAATGTGGAAATATGGGCATGTTTGCCCCTATGCTGTGTGGTCTCTAGATTTCTATATTTGCTTTGCTTTTGTCTGCTCTAGTAATCTCCCTCCTTTTGATCTGTGGCCTGGGAAAATGTGGTTTCTTTGTATTTCAAATAAAAGTAAAATAGTTTTTTGAGTGGTTCACTCAAGAGTAAA

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