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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TALDO1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:54524823-54525097  UCSC
Coordinates (T2T) chr1:54408157-54408431  UCSC
Coordinates (hg19) chr1:54990496-54990770  UCSC
Strand +
Parental Sequence NM_006755.2
Parental seq. overlap 260 bp
Parental seq. overlap (%) 21.7%
Genomic Region Intergenic
Retrocopy Summary TALDO1P1, located on chr1:54524823-54525097, is a retrocopy of the parental gene TALDO1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TALDO1
Full Name transaldolase 1
Also known as TAL|TAL-H|TALDOR|TALH
Coordinate chr11:747464-765012
Strand +
Gene summary Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TALDO1P1
Bonobo Pan paniscus TALDO1P1
Gorilla Gorilla gorilla TALDO1P1
Orangutan Pongo abelii TALDO1P1
Gibbon Nomascus leucogenys TALDO1P1
Crab-eating macaque Macaca fascicularis TALDO1P1
Rhesus Macaca mulatta TALDO1P1
Baboon Papio anubis TALDO1P1
Golden snub-nosed monkey Rhinopithecus roxellana TALDO1P1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TALDO1P1
GCAGATGGCTGTGGAGAAGCTCTCTGATGGGATCCGCAAGTCTGCTGCTGACGCAGTGAAGCTGGAGTGGATGCTGACAGAATGAATGTTCAATGCAGAGAATGGAAAGTAGTGCAGCCATGAGGCTGGACTCCAGATCTGCACTGCTGGCCAGCTGGGGTCTGACTGCACATGGCTTCTGATGAATCTTGCGTTTTTTACAAATCGGAGCAGGGACAGATCATAGATTTCTGATTTTATGTAAAATTTTGCCTAATACATTAAAGCAGTCACTT
>NM_006755.2
AGACCCCTCGGTCTTGCTATGTCGAGCTCACCCGTGAAGCGTCAGAGGATGGAGTCCGCGCTGGACCAGCTCAAGCAGTTCACCACCGTGGTGGCCGACACGGGCGACTTCCACGCCATCGACGAGTACAAGCCCCAGGATGCTACCACCAACCCGTCCCTGATCCTGGCCGCAGCACAGATGCCCGCTTACCAGGAGCTGGTGGAGGAGGCGATTGCCTATGGCCGGAAGCTGGGCGGGTCACAAGAGGACCAGATTAAAAATGCTATTGATAAACTTTTTGTGTTGTTTGGAGCAGAAATACTAAAGAAGATTCCGGGCCGAGTATCCACAGAAGTAGACGCAAGGCTCTCCTTTGATAAAGATGCGATGGTGGCCAGAGCCAGGCGGCTCATCGAGCTCTACAAGGAAGCTGGGATCAGCAAGGACCGAATTCTTATAAAGCTGTCATCAACCTGGGAAGGAATTCAGGCTGGAAAGGAGCTCGAGGAGCAGCACGGCATCCACTGCAACATGACGTTACTCTTCTCCTTCGCCCAGGCTGTGGCCTGTGCCGAGGCGGGTGTGACCCTCATCTCCCCATTTGTTGGGCGCATCCTTGATTGGCATGTGGCAAACACCGACAAGAAATCCTATGAGCCCCTGGAAGACCCTGGGGTAAAGAGTGTCACTAAAATCTACAACTACTACAAGAAGTTTAGCTACAAAACCATTGTCATGGGCGCCTCCTTCCGCAACACGGGCGAGATCAAAGCACTGGCCGGCTGTGACTTCCTCACCATCTCACCCAAGCTCCTGGGAGAGCTGCTGCAGGACAACGCCAAGCTGGTGCCTGTGCTCTCAGCCAAGGCGGCCCAAGCCAGTGACCTGGAAAAAATCCACCTGGATGAGAAGTCTTTCCGTTGGTTGCACAACGAGGACCAGATGGCTGTGGAGAAGCTCTCTGACGGGATCCGCAAGTTTGCCGCTGATGCAGTGAAGCTGGAGCGGATGCTGACAGAACGAATGTTCAATGCAGAGAATGGAAAGTAGCGCATCCCTGAGGCTGGACTCCAGATCTGCACCGCCGGCCAGCTGGGATCTGACTGCACGTGGCTTCTGATGAATCTTGCGTTTTTTACAAATTGGAGCAGGGACAGATCATAGATTTCTGATTTTATGTAAAATTTTGCCTAATACATTAAAGCAGTCACTTTTCC

Publications

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