Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPPL2AP2
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:49364483-49366772  UCSC
Coordinates (T2T) chr15:47172709-47174998  UCSC
Coordinates (hg19) chr15:49656680-49658969  UCSC
Strand -
Parental Sequence NM_032802.4
Parental seq. overlap 2147 bp
Parental seq. overlap (%) 29.4%
Genomic Region Intragenic (FAM227B)
Retrocopy Summary SPPL2AP2, located on chr15:49364483-49366772, is a retrocopy of the parental gene SPPL2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPPL2A
Full Name signal peptide peptidase like 2A
Also known as IMD86|IMP3|PSL2
Coordinate chr15:50702266-50765712
Strand -
Gene summary This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SPPL2AP2
Bonobo Pan paniscus SPPL2AP2
Gorilla Gorilla gorilla SPPL2AP2
Orangutan Pongo abelii SPPL2AP2
Green monkey Chlorocebus sabaeus SPPL2AP2
Rhesus Macaca mulatta SPPL2AP1
Golden snub-nosed monkey Rhinopithecus roxellana SPPL2AP1
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPPL2AP2
GCCACGGAGGCAGCGCAGTGGCGGGACTCCCAGCCTACCCCACCTAGTGAGCCGCGCCGCGCCACCCCACCCGCCACCCACCAGTCCGATGGGGCCGCAGCGGCGGCTGTCCCCTGCCACGGCCGCCCTGCTCTGGGGCTTCCTGCTCCAGCTGACAGCCGCTCAGGAAGCAATCTTGCATGCGTCTGGAAATGGCACATCCAAGGACTACTGCATGCTTTATAACCCCCATTGGTCAGCTCTTCCAAGTACCCTAGAAAATGCAACTTCCATTAGTTTGATGAATCTGACTTCCGCACCACTATGCAACCTTTCTGATGTTCCTCCTGTTGACATAAAGAACAAAGCAGTTGTGGTGCAATGGGGCAGCTGCCATTTTCTTGAAAACACCAGAAATGCACAGAAAAGAGGTGCTGAAGCAATGTTGGTTGTCAATAACAGTATCCTATTTCCTACCTCAGGTAACAGATCTGAATTTCCTGATGTGAAAATACTGATTGCATTTATAAGTGACAAAGACTTTATAGATATGAAGCAGACTCTAGGAAATAACATTACTGTGAAAATGTGTTCTCCATCGTGGCCTAACTTTGATTATACTATGGTGGTTATTTTTGTAATTGCTGTGTTCACTGTGGCATTAGGTGGATACTGGAGTGGACTAGTTGAATTGGAAAACTTGAAAGCAGTGACAACTGAAGATAGATAAATGAGGGAAAAAAAAGGAAGAATATCTAACTTTTAGTCCTCTTACAGTTGTAATATTTGTAGTCATCTACTGTGTTATGATGGTCTTACTTTATTTCTTCCACAAATGGTTAGTTTATGTTATGATAGCAATTTTCTGCATAGTATCAGCAATGAGTCTGTACAACTCTCTTGCTGCACTAATTCATAAGATGCCATATGGACAATGCACAATTGAGTGTCGCGGCAAAAGCATGGAAGTGAGACTTATGTTTCTCTCTGGACTGTGCATAGCAATAGCTATTGTTTGGGCTGTGTTTCAAAATGAAGACAGGTGGGCTTGGATTTTACAAGATATCTTGGAGATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGGCCAGCTTCAAGTCATGTGTGATACTTCTAGGCCTTCTCCTCCTCTATGATGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTAAACTTGCAGCTGGACCTTTTGAAAATACTGAAACATTGCCAGTAGTCATCAGAGTACCAAAGCTGATCTGTTTCTCAGTAATGAGTGTGTGCATCATGCCTGTTTCAATATTGGGCTTTGGAGACATTATTGTACAGGCCTGTTGCTTGCGTACTGTAGAAGAGTTGATGTTTAGACTGGTTCTTCGTATATATACTATGTTTCCTCTACAGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCTATTTAGTAACTTGCACACTTATTATTGCCTCAGTTGTTGCCTGGAAATGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGATGATGGACCATCTGTATTATGCAAAAAACGAAGAAAACCCTGTGATGTCTGGTGAACAGATTGTCCAGCAATAATATTATGTGGAACTGCTATAATGTGTCATTGATTTTCTACAAATAGACTTTGACTTTTTAAATTGATTTTTGAATTGACAATCTGAAAGTCTTCAATGATATGTTTGCAAATATATATTTTTATGAGCTGGTACTGACAGTTACATCATAAATAATTAAAATGCTTTGCTTTTAATGTTAAAGTTGTGCCTTCACATTAAATAAAAGGATATGGTCTGTGTAGTTTCCAAGATGTATTACATAGAGTATATTTTTCTTAAAAAAAAAAATGCCTTGACCCATCCCTATGCTTTTTTACTCAAATGTTTCTTCCAACTCTAATGGTAGATAAAAGTATTACTATCAAAGTGAGTTTCTGAATGGGTTTTACTGTAAATAATTATGCAAATTTTATCTGCTTTATAGAAATAACTGTTTAAGACCATGCAAGAAGGCAGTTCAACGGTGAAAATTTGGACCTTTTATCACTGCAGAGGTTAGAAATATAAAATTTTGGAATAAATGTAAGTGCATATTTTTGTAGTATGTTTTTTTAAAACCCAATCCTTTCATAAACTTGAGAACTGAAATTACTTCAGACTGCATGTGTATTATATTAAGAACATTTTTTCAGCTGTAGAGAAACATAATATATAGa
>NM_032802.4
AGTCGCGCTGCTGTGGCGGCCGCTGTAGCAGCGGcggtccagtcgtagcccggccgcccgcgcctgtccggtccggtccggCCACGGAGGCAGCGCAGCGGCGGGACTCCGAGCCTACCCCGCCGAGTGAGCTGCGCCGCACCGTGCCGTCCCACCCGGCACCCACCAGTCCGATGGGGCCGCAGCGGCGGCTGTCCCCTGCCGGGGCCGCCCTACTCTGGGGCTTCCTGCTCCAGCTGACAGCCGCTCAGGAAGCAATCTTGCATGCGTCTGGAAATGGCACAACCAAGGACTACTGCATGCTTTATAACCCTTATTGGACAGCTCTTCCAAGTACCCTAGAAAATGCAACTTCCATTAGTTTGATGAATCTGACTTCCACACCACTATGCAACCTTTCTGATATTCCTCCTGTTGGCATAAAGAGCAAAGCAGTTGTGGTTCCATGGGGAAGCTGCCATTTTCTTGAAAAAGCCAGAATTGCACAGAAAGGAGGTGCTGAAGCAATGTTAGTTGTCAATAACAGTGTCCTATTTCCTCCCTCAGGTAACAGATCTGAATTTCCTGATGTGAAAATACTGATTGCATTTATAAGCTACAAAGACTTTAGAGATATGAACCAGACTCTAGGAGATAACATTACTGTGAAAATGTATTCTCCATCGTGGCCTAACTTTGATTATACTATGGTGGTTATTTTTGTAATTGCGGTGTTCACTGTGGCATTAGGTGGATACTGGAGTGGACTAGTTGAATTGGAAAACTTGAAAGCAGTGACAACTGAAGATAGAGAAATGAGGAAAAAGAAGGAAGAATATTTAACTTTTAGTCCTCTTACAGTTGTAATATTTGTGGTCATCTGCTGTGTTATGATGGTCTTACTTTATTTCTTCTACAAATGGTTGGTTTATGTTATGATAGCAATTTTCTGCATAGCATCAGCAATGAGTCTGTACAACTGTCTTGCTGCACTAATTCATAAGATACCATATGGACAATGCACGATTGCATGTCGTGGCAAAAACATGGAAGTGAGACTTATTTTTCTCTCTGGACTGTGCATAGCAGTAGCTGTTGTTTGGGCTGTGTTTCGAAATGAAGACAGGTGGGCTTGGATTTTACAGGATATCTTGGGGATTGCTTTCTGTCTGAATTTAATTAAAACACTGAAGTTGCCCAACTTCAAGTCATGTGTGATACTTCTAGGCCTTCTCCTCCTCTATGATGTATTTTTTGTTTTCATAACACCATTCATCACAAAGAATGGTGAGAGTATCATGGTTGAACTCGCAGCTGGACCTTTTGGAAATAATGAAAAGTTGCCAGTAGTCATCAGAGTACCAAAACTGATCTATTTCTCAGTAATGAGTGTGTGCCTCATGCCTGTTTCAATATTGGGTTTTGGAGACATTATTGTACCAGGCCTGTTGATTGCATACTGTAGAAGATTTGATGTTCAGACTGGTTCTTCTTACATATACTATGTTTCGTCTACAGTTGCCTATGCTATTGGCATGATACTTACATTTGTTGTTCTGGTGCTGATGAAAAAGGGGCAACCTGCTCTCCTCTATTTAGTACCTTGCACACTTATTACTGCCTCAGTTGTTGCCTGGAGACGTAAGGAAATGAAAAAGTTCTGGAAAGGTAACAGCTATCAGATGATGGACCATTTGGATTGTGCAACAAATGAAGAAAACCCTGTGATATCTGGTGAACAGATTGTCCAGCAATAATATTATGTGGAACTGCTATAATGTGTCATTGATTTTCTACAAATAGACTTCGACTTTTTAAATTGACTTTTGAATTGACAATCTGAAAGAGTCTTCAATGATATGCTTGCAAAAATATATTTTTATGAGCTGGTACTGACAGTTACATCATAAATAACTAAAACGCTTTGCTTTTAATGTTAAAGTTGTGCCTTCACATTAAATAAAACATATGGTCTGTGTAGTTTCCGAGATGTACTATATACAGTATATTTTTCTAAAAAAAAATGCCTTGACCCACCCCTATACTTTTTTTTAACGAAATCTGTTTCTTTCAGCTCTGATGGTAGATACAAGTAGTTACTATTTCTGAATGGGTTTTACTGTAAAGAATTATGCAAATTggccaggcgcggtggctcacgcctgtaatcccaacactttgggaggccaaggcgggcggatcacgaggtcaggagatcgagaccatcctggctaacacggtgaaacccctctctactaaaaataccaaaaattagctgggcgtggtggagggtgcctgtagtcccagctactgggaaggctgagacaggagaatggcgtgaacccgggaagtggagcttgcagtgagccaagatcacgccactgcactccagcctgggcgacagagtgagactccatcccaaaaaaaaaGATTTATGCAAATTATATCTGCTCTGTAGAAATAACTGTTTAACACCATGCAAGAAGGCGGTTCAACGGTGAAAATTTGGACCTTATATCACTGCAGAGGTTAGAAATACATAATTTTGGAAATATAAGTGCATATTTTTGTAGTATTTTTTTAAACCCAATCCTTTCATAAACTTGAGAACTGAAATTACTTCAGACTGCACGTGTATTATATTAAGAACATTTTTCCAGATATAGAGAAACATAATATATAGAACTAGTCACTAAAAGGAGACAGACACTGAAATCTAGTTTTCATTGGTTTGACAGCCTTTTTTTTTTAAATGTAGCTTAAATTTCAGTACTAACATTCAGTTTCACTTTGGTATTTCTGATCTTTGCAATTTGGTTCTGTTAATGTTAAGGTTTGATTTTTTAAAAAAATTATTTTTCTTAAGAAATTATGTATTAATACATATGGCTCATCGTTGAATACAGCATTCCTAACATTATCCCACATTCCCCCACTCCCACCCGTTATCTTTTTTTCTTCCTGATGCCCACCCCTTTTCCCATAGGTAATGATTCTTAATCTTGGTGGAGGATGTACAAAGTGCGGTTCAGAGAAAAGAATTGGCAACAACAGCAAGAGACTTGGTGTTAGTCTCAGTTTAATTACAATACAAGGAAGAGTTGAGTAATTTGCCGCATCTCAAGACCTTGTATCTCAGttttctttttttttttttttttttttttgagacggagtctcgctctgtcgcccaggctggagtgcagtggcgggatctcggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccaagtagctaggactacaggcgcccgccactacgcccggctattttttgtagttttagtagagacggggtttcaccgttttagccgggatggtctcgatctcctgacctcgtgatccgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgcccggccATATctcagttttctaatctgtaaaatgagtaggttagaccagctaatcactctggtaccttccaactTGAAAAAAGTTTTTTCCCCATTCTTTGGTAAATTTTAGATGTGGCCTGAACATTCTCCTGGAAGTCAGAGGTCAAATTATCTTTCCATTTTCTTTTATTTTAGTAAGAATTTCGCAAATGACAAGTGATAACAAAGGCAGCAGGATTTTTCATTTCTCTGTAAATAATGTATAAAATATGTGAACAGAACTATATCTTTCATCTAAGGCCAGTTCAATTTATTAAAAATAAAACTAATGCCTTTTAAAATTGATCAGACCTTTGATACTTGAACTAAATTTTGCATTAGAGACTTTTTAAAAATTGTTCGCTTTTGCTGAATAAATTGCAAATAGAGAAGCTTCATTGACAGTCAGTCCCTCTCTGCTTAATGCAGTTATGGGTCCTTTCGTTTATGGCAAATGACTTACCTGACAAGAGTTAATTTTGCCTCCATTGTATCAAGTTTGAATATTTTCCAAGAAATCTGATTTATTTGGCAGACTCTGAGAGAGAGAACAGATTAAGTGCCGTTTTAAAACTCTGTATTTTCATTTATAATAATAAAATATTTGCCAAAATACAGCTGTTTTGTAAAATTATCTGCACCCTCATCCAAGCTTTATATTTAATAGCCTTAATCACATTTTATGAAGAATGTTAAAGAAAATTTTTTTTTTACTACATCGAAATGAGATAATTAAtttcttttttttttttttggaaatggagtctccctctgtcacccaggctggagtgcagtagcaagatcttggctcactacaacctctgcctcctggttcaagcaattttcctgcctcagcctcccaagtagacgggattacaggtgcgtgccaccacacctggctaatttttgtatttttagtagagacggggtttcaccttgttggtcaggctggtcttgagctcctgacctcatgatctgcccgcctcagactccccaagtgctgggattgcaggcatgagccaccgcgcctggcAAAATAAGATAATTTCTCAAAATAATTTGGTTTCATATAACTGGAGTAGTAATTAATATTTTAACTTCATCAACTAGATGTATCTCCTCAGTAGCATAGTAACTGGTACATCCAGAAATCTGAAATCCGAGTTACTTGATACAAATTCTACTTTATCTAACCATTAGTTATTAAGGAGGTAAAATCTTGTTCTAATTTGCTATTAAAATCTTATTGGTTAAATAGAAATAAGAAAAAGTATAATTAAGTTTCTTCATCCTCAATGTCAACTTTATATTGTAATTAAATGTGTAGCAACCAAGCTGACAATAGTGATTAAGAAATTAAAGTACAGAAATATTTTATTTGGGGACTCAAAATGAACAAAAGATAGATAAGATTAAAATTTCACTTAAAAAGCTGCCATCTCTTCCTCTCTTGCCCTCCCACCACCAATAACTTTAAGGGGAAGAGAAGCTGGTTTTTTCCCTAAACATGTCTTTAAAATAATGATACACTGTATTTATTAATTCTTGATGCAAAAAAAAAAAAGTTAGAAAATCCCTTTGAACATTTTTGTGGCTTATCAACAGAAATCACTATCTCAAATTGTAATGTAGATTACTTTTGTCTCAGTTTAGTTTAGCAAAAATAAATGTGAGGCTTGTGGGGAAAGACCTTGATATTCTAATACATTATATTTTCTTCTAGCTTGTAGAtttttttttttttttttttttgagacagagtttcgctctttttgcccaggctggagtgcaatggcatgatatcagctcactgcaatctccgactcccgggttcaagcaattctcctgactcagcctcctgagtagctgggattataggcatgtgccaccacacccggctaatatagtatttttagtagagacggggtttctccatgttgatcaggctggtctcgaactcccaacctgaggtgatccgcccgcctcagcctcctaaagtgctgggattacaggcatgagccaccgtgcctggcACTTGTAGATTTTTTTTTAGATTAGCAATTCCTTAGTAGAATCTGCAATTTATTTCTCTTTTAAAGAGAATTTTAACCCATCTGCTATTGGCATTCTTATATTTTACTTGTCCATAGAGATTTTAGTGAATTGATACATTTATAATAAATACAAATGAGCTTTCCAGTTTTCTTTGCTCTTTCAATTTATGCTTTAGTATAAGCAAAAATTACTATTTTTACATTTTTAAAAAttgtgggtacatgtaggtgtatatatttatggagtgcatgagatgttttgatacaggtatgcaatgtgaaataagcggatcatggagaatggggtatccattccctcaagcatttatcctttgagttatagacaTATTTTACATTTGAATAAAAAATATTTGAACTAAggccgggtgcggtggctcacacctgtaatcccagcactttgggaggccaaggcgggtggatcatgaggtcaggagtttgagaccagcctgaccaacatggtgaaaccccgtctctactaaaaatacaaaaattagctgggtgtggtggggctcgcctgtaaccccagctactcaggagactgaggcaggagaatcgcttgaacctgggaggtggaggttgcagtgagtcgagatcacaccactgcactccagcctgggcgacagagcgagactccatctcaaaaaaaaaaaaaaaaaaaaaaaatatatatatgtatatatatatatatatatatgtatatatGAACTAATTTATTTAGGCTTAATCTCTAAAATTTCAGCCTGATCTTAACCAATGAAATTTCAAAAACAAAAACTGTACTTCAGTCTACAATTGAATGGAATTCAGTGTAGACCAGTACAATGGAATGTACTggctgagatgggagggtcccttgagcccaggagtttgaggctgtagtgagctgtgattgtgtctgtgaatagtgactgcactccagcctaggtgacatagcaagatgccatctcaaagaaaTATAGATATATAACATAAAATAAATAACTTTATACATTTCCTGGAGGAAAAGTACTCTGTAAATTCAAGAGATCTGAATCAAATTACTCAACCTTTTGGAATTTGATCCTCTACTGTAATACTCATATGCTAGATTACTGAATTTTCAGAGTGAAAAAAAATTGACAGGGTAATATATAGGCCATATTATAGTGAAGATCATAAGTATAAATGTCCTCGTTTAATCTTTCCATATTGAGGACAGCCTCTGCATATAAAAATGTTCATTGGGAGAAAAATTATTTTTAAAACTAAATTTTTATAGTAGTCCTCCATTACTGGCAATTAAGGAGCAACCCACAAAATGTCATTATGTGGTTCTTTGATTAGGCATAAAAAGTATTGCAAACAGCTTTTCTATTCCTTTGGAATATGAATCTTTTTAATGTCTAAAGTTAACCTGCAACATTTTCTAGTAGGACAAGTCAATGTAAATTAGGTAATTTTTGCCTGTTTTATACCTTCTGTTGCATTTTGTTCAAATGAAAACATTTTTTAAAACATGATTGAATTTTTACTTCTCAGATAATTGGTTTGAGTGTGGAATTTCTTTTTTAACACTTTGATATGTAAGTTAGTGTAAATTAATACTTTTATAACACTACTAGGCTTTATATTTTTATGGAATGTTTTAAAATTTGAAATTTTTGAAGTGTTAATTTAGCAGTACTTTATCATTATGTGCCAATACTGACAAGAAAAACAATTTTTTATGTATTTAATATACTATGGTATTCAATAAATTCTATTTTAAAATAAAA

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