Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HADHP1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:56192079-56193161  UCSC
Coordinates (T2T) chr15:53994940-53996022  UCSC
Coordinates (hg19) chr15:56484277-56485359  UCSC
Strand -
Parental Sequence NM_005327.7
Parental seq. overlap 925 bp
Parental seq. overlap (%) 51.1%
Genomic Region Intragenic (RFX7)
Retrocopy Summary HADHP1, located on chr15:56192079-56193161, is a retrocopy of the parental gene HADH. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HADH
Full Name hydroxyacyl-CoA dehydrogenase
Also known as HAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD
Coordinate chr4:107989889-108035171
Strand +
Gene summary This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HADHP1
Bonobo Pan paniscus HADHP1
Gorilla Gorilla gorilla HADHP1
Orangutan Pongo abelii HADHP1
Gibbon Nomascus leucogenys HADHP1
Green monkey Chlorocebus sabaeus HADHP1
Crab-eating macaque Macaca fascicularis HADHP1
Rhesus Macaca mulatta HADHP1
Golden snub-nosed monkey Rhinopithecus roxellana HADHP1
Marmoset Callithrix jacchus HADHP1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HADHP1
CAGGTTGCTGCAGTGACCGGCCACACAGTAGTGTTGCTAGACCAGACAGAGGACATCTTGGCAAAATATAAAGAGGGAATTGAGAAAAGCCTTAGGAAAGTGACAAAGAAGTTGTTTGTAGAAAACCCTAAGGCTTTTGATGAATTTGTGGAGAAAACCCTAAGCAGCATATCAACCAGCACAGATGCAATATCCGTAGTCCACAGCACAGACCTAGTGGTAGAGGCCATTGTAGAAAATCTAAAGGTGAAAATCAAGCTCTCCAAGAGGTTGGACAAGTTTGTTGCTGAACATACAAGTTTGCCAGCAGCACTTCCTCTTTGCAAATTACAAGCATAGCCAATGCTACCACCAAACAAGACCGATTTGCTGGCCTCCATTTACTCAACCCAGTGCCCCTGATGAAATTTGTAGAGGTCTTTAAAACACCAGTGACCACCCGAAAGACATTTGAATCTTTGGTAAACTTGAGCAAAACCCTGGGAAAGCATCCTGTTCCTTGCAAGGACACTCCTGGGTTTATTGTCAGCTGTCTCAGGATTCAACACCTCATGGAAGCAGTCAGGCTGCATGAATGAGGTGATGTATCCAAGGAGAACACTGACACTGCTATGTAGTTAGGAGCCAGGTACCCCATGGGCTCACTTGAGCTTCTAGATTACGTTGGGCTGGATTCTGTGCAGTTCATCATGGATGGATGGCATGAAATAGATACAAAGAACCCCATATTTCAGCCCAGCCCATCCTTGAAAAAGCTGATGGCAGAGAAGAAGCTTGGCAAGAAGTCTGGAGAAGGATTTTACAAATACATGTGATGCTCAGCTTCTCTGGCACTGAGAAGAATCCCTGTGAGCGCTTACCAGCCAGCACCCAAAGTGCCTGTGAGAATACTCTTTGGTCAGACATTCCCTCACACAGCACAGTCTATTTGATAAGCATTTTGATTGTAATCTATCCGAAGTTATTATTACGCTAGATACAGTAGTAACAGATTCCACCATTAAGAACTAATTCCCATGTTTAGTCTGTTTATTTCTGTGTATTTTCTAAAAAGCGTTATACTGTTGGTGCTTTGGAACAAAT
>NM_005327.7
CTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGGTTGCTGCAGCAACTGGTCACACAGTAGTGTTGGTAGACCAGACAGAGGACATCCTGGCAAAATCCAAAAAGGGAATTGAGGAAAGCCTTAGGAAAGTGGCAAAGAAGAAGTTTGCAGAAAACCTTAAGGCCGGCGATGAATTTGTGGAGAAGACCCTGAGCACCATAGCGACCAGCACGGATGCAGCCTCCGTTGTCCACAGCACAGACTTGGTGGTGGAAGCCATCGTGGAGAATCTGAAGGTGAAAAACGAGCTCTTCAAAAGGCTGGACAAGTTTGCTGCTGAACATACAATCTTTGCCAGCAACACTTCCTCCTTGCAGATTACAAGCATAGCTAATGCCACCACCAGACAAGACCGATTCGCTGGCCTCCATTTCTTCAACCCAGTGCCTGTCATGAAACTTGTGGAGGTCATTAAAACACCAATGACCAGCCAGAAGACATTTGAATCTTTGGTAGACTTTAGCAAAGCCCTAGGAAAGCATCCTGTTTCTTGCAAGGACACTCCTGGGTTTATTGTGAACCGCCTCCTGGTTCCATACCTCATGGAAGCAATCAGGCTGTATGAACGAGGTGACGCATCCAAAGAAGACATTGACACTGCTATGAAATTAGGAGCCGGTTACCCCATGGGCCCATTTGAGCTTCTAGATTATGTCGGACTGGATACTACGAAGTTCATCGTGGATGGGTGGCATGAAATGGATGCAGAGAACCCATTACATCAGCCCAGCCCATCCTTAAATAAGCTGGTAGCAGAGAACAAGTTCGGCAAGAAGACTGGAGAAGGATTTTACAAATACAAGTGATGTGCAGCTTCTCCGGCTCTGAGAAGAACACCTGAGAGCGCTTTCCAGCCAGTGCCCCGAGTGCCTGTGGGAATGCTCTTTGGTCAGACATTCCCTCACACAGTACAGTTTAATAAATGTGCATTTTGATTGTAATCTATCGAAGTGATTATTACACCAGTTACAGCAGTAATAGATTCTCCATTAAGAAATAATTCCCTTTTTTAGTCTGTTCATTTCTGTGTATTTTCTAAACAGCTTTACACCCTTGGTGCCTTGGAGCAAACATGTTTTTTGAACCTTGTCATTTTTGTGAAGAATTGCCTAGATTCCTTCTCTCATCAACGGGAAAGTACTTCCTCTGAGAGTGCGAGTGCACCATGCTCACTGTTGCTGCGTGGGAGAGTCACAAGCCACTGGCAAGCAAGTGGTATAGTCTGTGAAGCACTGCAGCGAGCAGCACCTGGATCTTGCCTTTATAAGAACATTTTACTACCTGCAGCTTTGAGTCTTGCCCTACATTTTGGGCATGACATAAGATGTGTCTTTATTCAGCTCGTCGTGAAGATGCTGCTGCTGAATGGGTCAGCATATCTCTGTTTGCATGGTTTGCAGGAGGTCGGTTTTCATGGTCATTCAGTTCCACAGATCTGAATGATTACTGTCTGTCTGTGTCTTTTTTCCATGAGAAATCACTGTTGCAAATTGCCTATAAATTGACTCTACTAAAATAACAATGTTTCAGTCTGAAAATTTGAATTGAAAAAAATGTATAATATAAAATTGTAATACACTCAAATGATTATAAAAGTAAAAGTTGGTAATTTAGGCAGAA

Publications

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