Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NMNAT1P5
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:59964885-59966210  UCSC
Coordinates (T2T) chr15:57766569-57767894  UCSC
Coordinates (hg19) chr15:60257084-60258409  UCSC
Strand +
Parental Sequence NM_001297778.1
Parental seq. overlap 893 bp
Parental seq. overlap (%) 23.4%
Genomic Region Intergenic
Retrocopy Summary NMNAT1P5, located on chr15:59964885-59966210, is a retrocopy of the parental gene NMNAT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NMNAT1
Full Name nicotinamide nucleotide adenylyltransferase 1
Also known as LCA9|NMNAT|PNAT1|SHILCA
Coordinate chr1:9942923-9996884
Strand +
Gene summary This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NMNAT1P5
Bonobo Pan paniscus NMNAT1P5
Gorilla Gorilla gorilla NMNAT1P5
Orangutan Pongo abelii NMNAT1P5
Gibbon Nomascus leucogenys NMNAT1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NMNAT1P5
tACAACAAGAGAGATGTCACAGTTTTCCATTTAGATCAACAACTTCAAGTTCTTAACATGGAAAATTCAGAGAAGACTGAAGTGGTTCTCTTTGCTTGCAGTTCCTTTAAACCTATCACCGACATGCACCTCAGATTGTTTGAGCTGGCAAAGTCTACATCAATGGAACAGGAAGATACAGAGTTGTCAAACTCATAATCTCTCCTGTTGGCAATGCATATTAGAAGAAAAGACTCATTTCTGGaGACTCATTCCTGCTCATCACTGGGTCATCATGGCAGAACTTGCCACCAAGAATTCCAAATGGGTGGGAGTTAATACCCGGAAAGTCTTCAGAAGGACTGGACAGAGATTGTTAAGACACCATCAAGAGAAAGTGGAGGCCAGTAACTGTGATCACTAGCAGAACTCATCTACACTAGCAAGGCCTGGACGGAAGAAGAAGTGGACTGAACAAAGACAAGAGTCTAGTCAAAAGAAATCCCTAGAGCCCAAAACGAAAGGTGTGCCAAAGGTCAAGCTGCTATGTGGGGCAGATTTATTGGAGTCCTTCGTGGAAGAGTGAAGATATCGCCTAAATCGTGGCAGGCTATGGGCGCATATGTATTAGTTAGGCTGGAAATGATGCGCAGAAATTCATCTATGAATCTGATGTGCTGTGGAAACACCAGAGCAACATTCATGTTGTGAAGGAATGGATTACTAATGACATCTCATCCACAAAAATCTGGAGAGCCCTCAGAAGGGGCCAGAGCATTTGCTACTTGGTACCAGATCTTGTCCAAGAATACATGGAAAAGCATAATTTGTACAGTTCCAAGAATGAAGACAGGAATGTTGCAGTCATCCTGGCCCCTTTGCAGAGAAATGTCACAGAAGCTAAGGCATAGGAATTCTACAGCATGATGTTTTGGACTTCCCTTTTCGGGATTTGAAACAACCTGGGTTTTAGTAACTGGGGAAAGAAATTGTGACGCTGTTGCCTAAACTAAAGCTTAAAAGTTTAGTAAAAATC
>NM_001297778.1
CCTTTCTGAGTTTCTTCCTAGCGAGGCCGAGAGGGTCTTTGAGGAAAATCCCGCATCCGGACACGCCTTGAGGGATGGCGTCAAACCCAGAGGCTTGGAAAAGACAACAAGGGAGGTGTCACAGTTTTCCATTTAGATCAACAACTTCAAGTTCTTACCATGGAAAATTCCGAGAAGACTGAAGTGGTTCTCCTTGCTTGTGGTTCATTCAATCCCATCACCAACATGCACCTCAGGTTGTTTGAGCTGGCCAAGGACTACATGAATGGAACAGGAAGGTACACAGTTGTCAAAGGCATCATCTCTCCTGTTGGTGATGCCTACAAGAAGAAAGGACTCATTCCTGCCTATCACCGGGTCATCATGGCAGAACTTGCTACCAAGAATTCTAAATGGGTGGAAGTTGATACATGGGAAAGTCTTCAGAAGGAGTGGAAAGAGACTCTGAAGGTGCTAAGACACCATCAAGAGAAATTGGAGGCTAGTGACTGTGATCACCAGCAGAACTCACCTACTCTAGAAAGGCCTGGAAGGAAGAGGAAGTGGACTGAAACACAAGATTCTAGTCAAAAGAAATCCCTAGAGCCAAAAACAAAAGCTGTGCCAAAGGTCAAGCTGCTGTGTGGGGCAGATTTATTGGAGTCCTTTGCTGTTCCCAATTTGTGGAAGAGTGAAGACATCACCCAAATCGTGGCCAACTATGGGCTCATATGTGTTACTCGGGCTGGAAATGATGCTCAGAAGTTTATCTATGAATCGGATGTGCTGTGGAAACACCGGAGCAACATTCACGTGGTGAATGAATGGATCGCTAATGACATCTCATCCACAAAAATCCGGAGAGCCCTCAGAAGGGGCCAGAGCATTCGCTACTTGGTACCAGATCTTGTCCAAGAATACATTGAAAAGCATAATTTGTACAGCTCTGAGAGTGAAGACAGGAATGCTGGGGTCATCCTGGCCCCTTTGCAGAGAAACACTGCAGAAGCTAAGACATAGGAATTCTACAGCATGATATTTCAGACTTCCCATTTGGGGATCTGAAACAATCTGGGAGTTAATAACTGGGGAAAGAAGTTGTGATCTGTTGCCTAAACTAAAGCTTAAAAGTTTAGTAAAAATCGTctgggcacagtggctcacgcctgtaatcccagcactttgggaggctgaggcaggtggatcacggggtcaagagatcgagaccatcctggccaatatggtgaaaccccatctctactaaaaatacaaaaattagctgtgtgtggtggcacgtgcctgtagtcccagctacttgggaggctgaggcaggagaatcacttgaccccaggtggtggaggttgcagtgagccaagattgcaccattgcactccagcctggcgacagagcaagactctgtctcaaaaaaaaaaaaaaaTTTAGTAAAAATCAATGGTAAGCTAAAATAAGTTTTTGTTTGTTTATTTGTTTTTGAGATGGAgtctctactaaaaatacaaaaaattagccaggcatggtgccgcataactataatcccagctacttgggaggctgaggcaggagaatcgcttgaacccgggaggcacaggttccagtgagccaaggttgtgccactgcactccagcctgggcaaaaaagcaaaactccatctcaaagagaaaaaaaaaaaagaccgggtgtggtggctcacacctgtaatcccagcactttgggaggcctaagtgggtggatcacgtgaggtcaagagttcaagaccagcctggccaatatggtgaaaccccatctctactaagaatacaaaaaattagctgagcatggtggtgggctcctgtagtcccagctacttgggaggctgaggcaggagaatcgcttgaacctgggaggcagaggttgcagtaagccaagatcgtgccattgcactccagcctgggtgacagagcgagactccatctcaaaaaaaaaaaaaaGCCTGACAGCTAGCAGGTTTCAGGATCCATCTGCCAAGTTAGTGAAAGGCTGGAGCCTCAAATCATACAGATGAGGGTCATTTTCTCCTCCTTAGCTTCTTGGAGTTTAAGAGTTGAAGGAGTCCTGAAAAGTAATGATAGAGCAAGATGAAGCTATCAGAACTGAATTTGGACTTCCTCTGGGAAACTACACCTAGTTCATCTGAAGTGTCACGTAAACTGCAGAAAGTTTCCAATGCTGGAAACTTCTCTCATACTATCGTGCCTTCCTACTCAGAAGTGCCTGTGCCCTGCTCAGCTGTGACTACTGACCTCAGGACCTCACTGGACAAGGCATGTGGGGACCCTTGCAGGAGCCCTGGTAAGGGTACAATGATCCTAttgttttttgtttttgagatggagtctcactctgtctcccaggctggagtgcagtggtgcgatctccgctcactgcaacctccgcctcccgggttcaagcaattctcctgcctcagcctgctgagtagctgggattacaggcacccactaccatgtccggctaattttgtatttttagtagagatggggtttcgccatgttagacaggctggtcttgaactcctgacctcaggtgatctgcccacctcggccttccaaagtgctgggattacaggcatgagccactgcacccagccTGATCCTATTGTTGCACTATTTATGGAGCAACAACTTTGTACAAAGAACAAGCTTTGTACAGAGAACAAGCTTGGCTTTTTCTCCCAACGCCGAGGATGCTGTTGATGCTGCCACGTAATAGCATAATTTTGGGTGTCCTCAAGGACAGAACTTCCACTTTGAATAATGGAAGTTAGAACAATGAATTTCACAGGGGAATAAATATTAATGACTGACGTGAAGAAAATATGCCATTGTTTATTCCCTCCTGCATCATTTCCATAATTTGCTTTTGTACTGTCAATTTAGAGGAAATGTGTGATGCTGGTGTTTTGTTTGGCCTGTTTGTTTGATGCTGGGGGTTTTATGTGTTGTACCCTTTACCCCTTACATTGTGTAATTTGAAAGTGGCAAACAAACCTGCAGTAAAAGTCCTTGATTGGCATCTTCATTCGGATGATGGAGAGCCTTTGTGGTAGTGTTTGCTTATGTGAACAGCAGGCCTTTCAGATAAGAGAAGTGGCTTTTCCTTGGTGATGAAGGGGTAGAGATTGAGCCATGGGGATGGTTTAGGTTAAAGAATGCTTTTTTTTGGCCATCATGAGGATCTAACAACAGAGTAGAAGGAAGGATGCCCTAGGTCAGCATGCAGGGTGGTGGGAGGGCTTTCATCTTCCTTACCCAAGCCTCTCTTTTCACTTTTCTAGAAGTCCAGAAGTTGTTATATGATGAAATAGCCTCCTTTAACGTTTATTTCTGGGTGCCAACGGAGGCCCATTCCTCTAACATTCTCATAATTTTTCTCAAAGGCCTATGATCTAAACATTTCACCACGGCATCCACTCAGCTGTGAGGCTGCGTACACAGTCTCCACCTCTGAAATCTGAACTTCGTTTACCAGTGGTGCTGTTTGAACTTCataatgtcagcacttcctgaacacttactgtgtgcttggcttgtgctcctgagtgccttatatCATAAGGAAACGGCAAAATCAGGGGACTGGTAtaaatggtgagctgagcttgaatctaagctttgtcttcagagccagtacccctaatctctCTTTCTGTAAAATATTACTTTTCAAAGAATGAAGTTGTAGCCAAATCTTGAAATTTTTCATTTACCCTAAGTGAGGACAAATAAAGCTTTCAACAACA

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