Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDK11AP1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:65301921-65302507  UCSC
Coordinates (T2T) chr15:63111299-63111885  UCSC
Coordinates (hg19) chr15:65594259-65594845  UCSC
Strand +
Parental Sequence NM_001313896.2
Parental seq. overlap 490 bp
Parental seq. overlap (%) 16.2%
Genomic Region Intergenic
Retrocopy Summary CDK11AP1, located on chr15:65301921-65302507, is a retrocopy of the parental gene CDK11A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDK11A
Full Name cyclin dependent kinase 11A
Also known as CDC2L2|CDC2L3|CDK11-p110|CDK11-p46|CDK11-p58|PITSLRE|p58GTA
Coordinate chr1:1702379-1724357
Strand -
Gene summary This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LOC469457P1
Bonobo Pan paniscus CDK11BP1
Gorilla Gorilla gorilla LOC101151839P1
Orangutan Pongo abelii LOC100440455P1
Gibbon Nomascus leucogenys CDK11BP1
Rhesus Macaca mulatta CDK11BP1
Baboon Papio anubis CDK11BP1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104653547P1
Marmoset Callithrix jacchus CDK11BP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDK11AP1
TGGCTACAGTAACCTTCCAGCAGTCAAGAAGATGACCTTCAGCCAGTACCCCTATAGCAACCTCTGCAAGGGCTTGGGGGCCTTGCTCTCAGAACAGGGCTTTCATCTTACGAACAAGTTCCTGACCTACTTCCCCGGGAGGAGCACTGAGGATGGCCGCAAGCGAGTATTTCTGCGAGATCGCCCCCCGCCCCCCCACTGACCCCTCGATGTTCCCCACGTGGCCCGTAAAGAGTGAGCAGCAGTGTGTGAAGTGGAGCACCAGCACGCCCCCACCCGACCCGCGCCCCGCCAGGGAGGCCTGGGCTACAGCCAGCTGGGTGACGACCACGTGAAGGAGACTGGCTTCCACTTCACCATCACGAACCAGGGCGCCTCGGTTGCGGGCCCGGCTTCAGCCTCAAGTTCTGGCAAGGTCAGAGCCGACTCCAAGTCATGGGGAGGATTCAGCCCGGACCACGGGGCAGCTGCTACGGCTGAGCTGCCTTGAGTCTCAGAACTCCTCATCTTTATTTTGTGTTCCACATTTTGTTTTTGTATTTTGGTTTGTAAATTTGTAGAATTAAATCACATTTTCCTTGTTGTGG
>NM_001313896.2
ATATCATCATTAGGCGTCAACACAGGAAGTGAGGATACTTCTGGCGAGCGCCGGTTGCTGTTTCTTCTCAGGCTCAGGGACCGGCCGCGGCCCCGTAGGGTGTTTTAACTCAAATGGGTGATGAAAAGGACTCTTGGAAAGTGAAAACTTTAGATGAAATTCTTCAGGAAAAGAAACGAAGGAAGGAACAAGAGGAGAAAGCAGAGATAAAACGCTTAAAAAATtctgatgaccgggattccaagcgggattcccttgaggagggggagctgagagatcactgcatggagatcacaataaggaacTCCCCGTATAGAAGAGAAGACTCAATGGAAGACAGAGGAGAAGAAGATGATTCTTTGGCCATCAAACCACCCCAGCAAATGTCTCGGAAAGAAAAAGTTCATCACAGAAAAGATGAAAAGAGAAAAGAAAAATGGAAGCATGCTAGAGTGAAAGAAAGAGAGCACGAACGTCGGAAACGACATCGAGAAGAACAGGATAAAGCTCGCCGGGAATGGGAAAGACAGAAGAGAAGGGAAATGGCAAGGGAGCATTCCAGGAGAGAAAGGGACCGCTTGGAGCAGTTAGAAAGGAAGCGGGAGCGGGAGCGCAAGATGCGGGAGCAGCAGAAGGAGCAGCGGGAGCAGAAGGAGCGCGAGCGGCGGGCGGAGGAGCGGCGCAAGGAGCGGGAGGCCCGCAGGGAAGTGTCTGCACATCACCGAACGATGAGAGAGGACTACAGCGACAAAGTGAAAGCCAGCCACTGGAGTCGCAGCCCGCCTCGGCCGCCGCGGGAGCGGTTCGAGTTGGGAGACGGCCGGAAGCCAGGTGAGGCCAGGCCGGCGCCTGCGCAGAAGCCAGCACAGTTAAAAGAAGAGAAAATGGAAGAAAGGGACCTGCTGTCCGACTTACAGGACATCAGCGACAGCGAGAGGAAGACCAGCTCGGCCGAGTCCTCGTCAGCGGAATCAGGCTCAGGTTCTgaggaagaagaggaggaggaggaagaggaggaggaggaagggagCACCAGTGAAGAATCAgaggaggaggaggaggaagaggaagaggaggaggaggagACCGGCAGCAACTCTGAGGAGGCATCAGAGCAGTCTGCCGaagaagtaagtgaggaagaaatgagtgaagatgaagaacgagaaaatgaaAACCACCTCTTGGTTGTTCCAGAGTCACGGTTCGACCGAGATTCCGGGGAGAGTGAAGAAGCAGAGGAAGAAGTGGGTGAGGGAACGCCGCAGAGCAGCGCCCTGACAGAGGGCGACTATGTGCCCGACTCCCCTGCCCTGTTGCCCATCGAGCTCAAGCAGGAGCTGCCCAAGTACCTGCCGGCCCTGCAGGGCTGCCGGAGCGTCGAGGAGTTCCAGTGCCTGAACAGGATCGAGGAGGGCACCTATGGAGTGGTCTACAGAGCAAAAGACAAGAAAACAGATGAAATTGTGGCTCTAAAGCGGCTGAAGATGGAGAAGGAGAAGGAGGGCTTCCCGATCACGTCCCTGAGGGAGATCAACACCATCCTCAAGGCCCAGCATCCCAACATTGTCACCGTTAGAGAGATTGTGGTGGGCAGCAACATGGACAAGATCTACATCGTGATGAACTACGTGGAGCACGACCTCAAGAGCCTGATGGAGACCATGAAACAGCCCTTCCTGCCAGGGGAGGTGAAGACCCTGATGATCCAGCTGCTGCGGGGGGTGAAACACCTGCACGACAACTGGATCCTGCACCGTGACCTCAAGACGTCCAACCTGCTGCTGAGCCACGCCGGCATCCTCAAGGTGGGTGATTTTGGGCTGGCGCGGGAGTACGGATCCCCTCTGAAGGCCTACACCCCGGTCGTGGTGACCCAGTGGTACCGCGCCCCAGAGCTGCTGCTTGGTGCCAAGGAATACTCCACGGCCGTGGACATGTGGTCAGTGGGCTGCATCTTCGGGGAGCTGCTGACTCAGAAGCCTCTGTTCCCCGGGAATTCGGAAATCGATCAGATCAACAAAGTGTTCAAGGAGCTGGGGACCCCCAGTGAGAAAATCTGGCCCGGCTACAGTGAGCTCCCAGTAGTCAAAAAGATGACCTTCAGCGAGCACCCCTACAACAACCTCCGCAAGCGCTTCGGGGCTCTGCTCTCAGACCAGGGCTTCGACCTCATGAACAAGTTCCTGACCTACTTCCCCGGGAGGAGGATCAGCGCTGAGGACGGCCTCAAGCATGAGTATTTCCGCGAGACCCCCCTCCCCATCGACCCCTCCATGTTCCCCACGTGGCCCGCCAAGAGCGAGCAGCAGCGTGTGAAGCGGGGCACCAGCCCGAGGCCCCCTGAGGGAGGCCTGGGCTACAGCCAGCTGGGTGACGACGACCTGAAGGAGACGGGCTTCCACCTTACCACCACGAACCAGGGGGCCTCTGCCGCGGGCCCCGGCTTCAGCCTCAAGTTCTGAAGGTCAGAGTGGACCCCGTCATGGGGAGAACTCAGCCGGGACCACAGGCGTGGCTACTGCGGCTGGAGCTGCGATGAGACTCGGAACTCCTCGTCTTACTTTGTGCTCCATGTTTTGTTTTTGTATTTTGGTTTGTAAATTTGTAGAATTAAATCATTTTCCTTGTTGTGGAGGAAAGAGCTGTGTTTTCTCCGTGACTTGCCAGGGCATCTTCGGGTGCCCACGTGGGGCAGCACAAACCTCCACACACCCTCTCCCACTCTCGACACGCACGGGGCTGGCTGGGCCGTGATTTGGAAAGGAACTGGTGGGAGCCGGGTGGATTGTTTAATCTTCGGAGCTGGAGACCTGTTTCTGTGTTGGGATGAGCGATGCCCTCTTGCCCCAACCCACTCGTCCAGACCAGCCCTGTCCACACAGGCCCCCGGCCCCCAACCCCCAGCCCCAGCTGTGCCAGCAGACTCGACAGGTTTTTATACAAGGTTGTTGAGTTTTAAAATGTATTAAAATATTCTTCGAGGAAAGCTC

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