Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GEMIN8P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:69803019-69804142  UCSC
Coordinates (T2T) chr15:67625138-67626261  UCSC
Coordinates (hg19) chr15:70095358-70096481  UCSC
Strand -
Parental Sequence NM_001042480.2
Parental seq. overlap 734 bp
Parental seq. overlap (%) 22.5%
Genomic Region Intergenic
Retrocopy Summary GEMIN8P1, located on chr15:69803019-69804142, is a retrocopy of the parental gene GEMIN8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GEMIN8
Full Name gem nuclear organelle associated protein 8
Also known as FAM51A1
Coordinate chrX:14006726-14029917
Strand -
Gene summary The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GEMIN8P2
Bonobo Pan paniscus GEMIN8P2
Gorilla Gorilla gorilla GEMIN8P2
Orangutan Pongo abelii GEMIN8P2
Gibbon Nomascus leucogenys GEMIN8P2
Green monkey Chlorocebus sabaeus GEMIN8P3
Crab-eating macaque Macaca fascicularis GEMIN8P2
Rhesus Macaca mulatta GEMIN8P2
Baboon Papio anubis GEMIN8P2
Golden snub-nosed monkey Rhinopithecus roxellana GEMIN8P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GEMIN8P1
TTCTGTACATTTCTCAGTAAAAGGGGACTTTGTACTGAGGTACAGGCATGTTCACCACAGTCCCAGTGGGCCTGTCACAGAGTGGATGTACTATGCCAGCCACTTGGAGGTCGGCAGACATGTTCTGCTGCCGACATGATGAATTTTCTCCTGACATCAAATGATGATTTTGTATATATTATACTGTTTTTTTTATGTTGTCGGTAACAATTCATTAAAGTTCTTGCCTAGAAAAGGAAAACTAGGCCCCTGCTTGGCCACCGCTCAGGATATGCAAGCTGAGAGCCCATGAGTTTCGGCACCCACTTGGACTTTCACAATCAGAGACGGCAGCGGTGAAGGCATGAACATTGAAAGCTACCAGGCCTTGGTATTCTCATCCGATATATGCAAGATACTGGCAACATTATCATCAAGCAATGGCTTCGATGCAAAGCCACCACAATGCCTACAGGAAGGCCGGGGAATCCTGTTGCAGTCTTCCTTGGTACTTCCCTCCTGCACTTCCTCCCCAAAGCTGTTACGATAACCAGGCTGCGTATCCTTAGTCCTTCTATGGCCATCATGTGACCTGGCAGGACTCCCCGTGCAGTTCTTTACATTTCAGAGGGTCTGGGCAGCAGCCACATGACAGCAGTAGAATCCAGGCATCCACAAGAGAAGACCAAGATTTGTCCAAAGAGGAAGAGATGGAGATCAAGTTAGATGCAGAGGTAGAATGTGACCTGAGCAATATGGAAATCACCAAAGAGCTCCGCCAGTACTCTGCAGAGTGCCTCGGTAGAGGCACAGAGAAGGACGGTGGTGACAGCAGCTGGATGCAGAGCACCTGGAAAGCTATGTGAAGGCTGACCACGACCTGACCTGTACTGCAACACCCGCTGGTTGGTAGAGGCCCCAACTGAGAGGCCTAGAGAGCAGCGTCCCAGGCCGAGATGAAGCGATTGTATGGGGACAGCGCCAAGATCCAGGCCATGGAGGCTGCGGTGCAGCTGAGCTTTGACAAGCACTg
>NM_001042480.2
AGTCGCCCCGGCAACAGCCGCCTCCCTCGCGTCCCCCACTCCCCCTCTGTCTCTCCAAGGAAAACTAGGCCCCTGCGCGGCCAACGCCCAGGATCCGCAAGCTGCGCGCCCACGAGTTTCAGCACCCATTTGGACTTTCACAATCAGAGATGGCAGCGGTAAAGGCATCAACATCGAAAGCTACCAGGCCTTGGTATTCTCATCCGGTATATGCAAGATACTGGCAACATTATCATCAAGCAATGGCTTGGATGCAAAGCCATCACAATGCCTACAGGAAGGCCGTGGAATCCTGTTTCAATCTTCCATGGTACTTACCTTCTGCGCTTCTTCCCCAAAGCTCTTACGATAATGAGGCTGCGTATCCTCAGTCCTTCTATGACCATCATGTGGCCTGGCAGGACTACCCCTGCAGTTCTTCACATTTCAGAAGATCTGGGCAGCATCCACGTTACAGCAGTAGGATCCAGGCATCCACAAAAGAAGACCAAGCTTTGTCCAAagaggaagagatggagactgagtcagatgcagaggtagaATGTGACCTGAGCAATATGGAAATCACTGAAGAGCTCCGCCAGTACTTTGCAGAGACCGAGAGGCATAGAGAAGAACGACGGCGGCAGCAGCAGCTGGATGCAGAGCGCCTGGACAGCTATGTGAACGCTGACCACGACCTGTACTGCAACACCCGCCGGTCGGTAGAAGCCCCAACTGAGAGGCCTGGTGAGCGGCGCCAGGCCGAGATGAAGCGTTTGTACGGGGACAGTGCTGCCAAGATCCAAGCCATGGAGGCCGCGGTGCAGCTGAGCTTTGACAAGCACTGTGACCGAAAGCAGCCCAAGTACTGGCCGGTCATCCCCCTGAAGTTCTGAGCTCAGGGCACAGGGTACCCAGCCTCTCCTTCTTCCTTTTGGGTACACGCTCTTTATCTCTCCTTCTGTACATTTCTTAGGGAAAGGGGACTTTGTACTGGGGTACAGGCATGTTCACCACAGTCCCAGTGGGCCTGTCACGGGGTGGATGTACTATGCCAGCCACTTGGAGGTCTGCAGGACATGTTCTGTTGCCAACATGATAAATTTTCTCCTGACATAAAATAATTTTGCATATACTATACTGGTTTTTTATGTTGTTGGTAACAGTTCAATTCATTAACGTTCTTGCCTAGAGATACTGCCTGGTGTtttgcttttttatcttttcttgtctttAACCTGTCTGAACTACACAAATGCCTTTAAAAAACCAGATATCCTCTCTGACTCTAGCTCCATTAGCCCCCACTAAAAATGAGCCAAGTGTGTAGTGAGACAAATACCACTACCTGTAGTGGAGAGGGATGCATGttctataaagggccagagagtgaatatctttggcactgcaagccacacggtcagtgttgtgactactcaaccctccctttgtagtgtgaaagcagctgtagacagtaagtaaacaaatgggtgtggctgtgttctaataaaactttatttataaaaacaggcggccgggcgcaatggttcatgcctgtaatcccagcactttgggaggccgaggtgggcagatcacgaggtcaggagatggagaccatcctggccaacatgatgaaacccgtcgctactaaaatacaaaaaatgagccgggcatggtggtgtgtgcctgtaatcccagctacgtgggagactgaggcaggggaattgcttgaacccaggaggcagaggttgcagtgagctgagatcgcgccactgcactccaacctagagaaagagcaagactccgtctcaaaacaaaaacaaaaacagactgcaggccagatttggtctacagatggtagtttgccaacTGCACCTCTCATGGAATGAAAATCACCTGCCTGACATTTTTATTCTTGTTATCTCATTATGTCTACAGAGCTTAGATGTCATACAGAATTGAGAGCAAAGAACAATAATTCCggcccggcgcggtggctcatgcctgtaatcccagcactttgggaggctgaggtgggcagatcacgagatcaggagatcgagaccatcctggctaacacggtgaaaccccatctctactaaaaatacaaaaaattagccgggcgtggtggcgggcacctgtagtcccagctacttgggaggctgaggcaggagaatggcgtgaacccaggaggcggagcttgcagtgagccgagctccagcctgggcaacagagtgagactccatctcaaaagaaaaaaaaaaaagaaCAATAATTCCCAAACCTGGTCACTGCTGCAGTCACCTCTGTTGCAGAAAACGCACAGTTGATTTCTTACTATATACAGCAAATATTGATTTGATAAAGGAATACATTTCTGAAAATGAAATCTAAAAGCTGATGGAGCAGGTCATTTATAAAAGCCAGCTGCCTTTTAAATAAGTTATTACAGTACATTGCCAGGGTGAGCCCATGTTGACCTGAGAAGATTAGCACATCCATCAAAGGCTGGTGAAAAGATTTAGTATTGACATGTTTCTCTCTAAGAACAGTTGGCTTCACATTCAGCCCCTGCCCTGAGACAAATGCATTATTTTCATCAGCCCTGGGTGCTTATTTTTCTAAGCTCTCATTTTATTACTGGAGTCACAATTTGTGTGTAGGTGTTGCCGACAAAAATGATAATTAACTTTCCCTTGAGGTGACACATAACTAAAATTTCAAATCTTTAGTATTTCTCCCTTTCATTTTAAATTCATATGCCTAACTATAAAATAACTGTGACTGAGATACAAGTACAAACCAAAGCCTGGAATTGCAGCAGGTGCTGAGGCATTTGAAAGTGAAATGTTTCTCTTCGCAAAGGACTCTTATACCCTCCCCTAAAGAAATCACCatgccggtctcacccctactggctttgttacctaaggcttcacctctcagtgcttctggttccttccttatccttaaaatgagtgttaataattctctcgtggggtcattgtgcggaccacattgagtagtgcctgtaaaacagtgctggctacacggtaaatactcaataaatgttgACACGTTTA

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