Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AK2P53
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:58629928-58631578  UCSC
Coordinates (T2T) chr1:58507897-58509547  UCSC
Coordinates (hg19) chr1:59095600-59097250  UCSC
Strand -
Parental Sequence NM_001625.4
Parental seq. overlap 1384 bp
Parental seq. overlap (%) 23%
Genomic Region Intergenic
Retrocopy Summary AK2P53, located on chr1:58629928-58631578, is a retrocopy of the parental gene AK2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AK2
Full Name adenylate kinase 2
Also known as ADK2
Coordinate chr1:33007940-33036883
Strand -
Gene summary Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla AK2P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AK2P53
ATCACAGGAAGGCTGATCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAAGAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTTGATCAGATGATAATGAAAAGGCCTTGAAAATCTGCCGGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTACTACAGGAAACGGGGGATCCACTCTGCCATCAATGCATCCCAGACCCCTGATGTCGTGTTCGCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATCCTAGTATCAGAAGGCCAGGCGAAACTGCAACACTGCTCATCACCCGGTGGCGTGATCCCTGCTCTTAGGTGCTGGGCAGAGGGAAAGGGTGGTCAGGGTGAGGATGGTGAGGGAGGGCTGGTGAGGGGCTGAGAGGAATACTTGAAACAACAGCAGTGTTATTGTAATGTGGCAGTTTATTTTATACATAGGTGAGAGTTTTTAAAGTGTAAGGGAAAAATTAATTTTTTAAAAAACACCATGCTTGGAGGGTGGGGGTAGAAATAGAGAGACACAATATTATTTCTAAGGAATCGGGTTTTCATTTACTCTGGACTGGTGAAAATATTTTTTAAAGCCAGTGCTCTAAGACCTCAGCTTTTATCTCAGAACCCCATGGGTTCCAGACCAAGAGTACAGGAAATCAAATTGTTGTCCTGTCTGTCTATAGCTTGGAACAGGGAGGCTTTGATTACTGACCCCGGTTCCACACACTGTAAGATCAAAAAACCATTTCCACATCTGAAAGAGATGTAAGGTGTATTCATAGGGATGGTGGCTCAACAAATCAAACAAACTGGAATCAAGGGGAGGGAGAAGGGAATGAAATGGAAAGGGAGGCTGATTCCCTTCCCCTGACTTACCACTAATTTACTAGGCTACGTAATCTCATGAGTAACCTCTCACAGCTACCCAGCACATGCCACAATCCTATGCTCTTGCCTTCTTTTATCTGCAATGTGTGAAGGGACTCTTTTAAATAAATGAGCAAGTGTCCTAAGCTATGTCATCCAAAGATTGTCCTTTCCATTCTCAAATCCTGTGACTGGGATCACTCAACAGCACTGTGATGTATTATTTTCAATGAGGTGCCTTTCTTAACTGACCAAATGCTGCCTTGTTTGGCCCCTAAATCAATAAAATATGTTAAAATTTGGACCTGTGAGGTGTGCGAACTGGTGGCAGTGAGAGACTTCGGCGGACATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTGTCCTAAAGGCTGTGCTGCTGGGGCCTCCCAGGGCCGGTAAAGGCACCCAGGCACCCAGATTGGCTGAAAACTTCTGTGTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTAGGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTGGAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGCTTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGa
>NM_001625.4
AAGCACTGGACCTGTGAGGCGTGCGAACTGGTGGCAGTGAGAGACTTCGGCGGACATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTGCTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGTGTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTAGGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTGGAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGCTTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGagaagcttgattctgtgattgaattcagcatcccagactctctgctgatccgaagaATCACAGGAAGGCTGATTCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAAGAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAAAAGGCCTTGAAAATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTACTACAGGAAACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTCGCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATGTAAAGACTTGGTTATGTTTATCTAATGTTGGGTCCAAGAAGGAATTTCTTTCCATCCCTGTGAGGCAATGGGTGGGAATGATAGGACAGGCAAAGAGAAGCTTCCTCAGGCTAGCAAAAATATCATTTGATGTATTGATTAAAAAAGCACTTGCTTGATGTATCTTTGGCGTGTGTGCTACTCTCATCtgtgtgtatgtgtgttgtgtgtgtgtgtgtgtgCATGCACATATGTGTTCACTCTGCTACTTTGTAAGTTTTAGGCTAGGTTGCTTTACCAGCTGTTTACttcttttttgttgttgttttgagacaaggtttcgctctgccaccctggctggagtgcagtggcgtgatcttggctcacggcaacctctgcctcctggggctcaagcaattatcccacctcagcctcctgagcagctgggactacaggtgcatgccacaacacctggctgatatttgtattttttgtagagacaggattttgccaagttgcccaggctggtcttgaactcctaggcttaagcaatccacccaccttggcctcctgaagtgccaggatcacagacgtgagccactacacccagccCAGCTGTTTACTTCTTTAACCATACTTTTGATTTTATTTTTTGACCAAAATGAACTAACCCAGGTAATCTTCCAGGGACCGCAATTCCAGAACCTCATAGTATTTCTTCCATTTCCAGCAGCTGATTAGAAGTCCAGGATCATGTGAAGTCAGGCAGGGTCACAGTTCCTGATGGCACATTATGGACAGAGAATTCCATTTTGTTTTCTAACCCATGATGAAAACCCACGTGAGTCAGTGTGTGAACAGGGATCATTAATTTTTTCCCCCTAGGTGGAAGGAAAAAGGCACTTACTTTGCAGGTTACAGAAATTACTGGGAGAGGATATCGTCATAAAAAGAGCCAGGCCAAATTGGAATATTTTTGTGATCTGCATCATGATGCTGAAAATAGCAATTATTTGGGAATTGGGTTTGAAAACTGAATTGTTGCCAGAGAATTAAACCAGGTGAAAGGTCCTTTTGAATTCAGATTGTCTTCTGAACATCCAGGCTGATCATCTGAGAGCAGTCAAATCTACTTCCCCAAAAAGAGACCAGGGTAGGTTTATTTGCTTTTATTTTTAATGTTTGCCTGTGTTTCCAAGTGTGAACAAAACAGTGTGTGATCTATTCTTGGATTCATTTTGATCAGTATTTATTCAAACCCAGTCTCTCTCCAGGACATAAAACTGAAATCAGATATGTTCTTTTTAAGCCCAAACCCTCTCCTTTCTAGATCCAACCCTTCACCCCTAATTTTATGATGGCTATAGCCATGGACTTCCCCAAGAAAAGATCACCCAGAAATAAGACCACCTGTGACAGTTACCAGCTTTTATTCATAACCTTAGCTTCCCAACTATTGAGCATTTTCTAAGGTCCCTGCTGTCTTTTGGTCTCTGGTTTGATTTGTGGCAAACAGATGAAGTAACAGACTGCTATGAAGGACCACAAAAACGGCAGCCTCTGGAAAAACCATTAGAAAGTCAGTGGCAGATCCAGTAAATAATATCGCCAGCCTCAGCATAATCTGCTGCTGACTCGATTCAGTGGACTCTAAAGTGCCCAGCCTCCTGACCTGAGCTCTCCTGCCATCTGTGAGACTACCAGAGGTCTTATCTGCTGTCCACATGGCAACTGGGCATGAGTACCTGGCCACCTTGCTTCCCTCTTTGCCTGGTCCAAGTGAGTGTCTGCTGCCTCTGTCCTGCCTTGTTTTCCTGGCTCTAAACCAACTCCACCCACTCTTAATGGAAACTCAGTCTGGCTTTGTGTGTTTCTGGGAAGCACATGACTTCTGGGAATGGGCAAGGAAGAGGAGTGAAACAAAAACTGTCAGCTATGTGTGCCTGGTCTGGGATCCTTCTCTGGGTGACAGTGGCATCATGAATCTTAGAATCAGCTCCCCTTTAACTAGGGACAATTGTAAGCACTTGGCCTCAAAGTTGAGGTTCTTGAATGTTTGCTAATTTTATGTGCATGATCCTTGCCCAAATATTTGTCATCCGTCCACATAGATTCACGTGTGCATACAACATGTACAAGTAATATTTGGGCTGCCCATAAGAACTGGAAGATTCATAGGGAATGCATATACCCTTCTCAGTATGGTTAGGATTCTGTTTTTGCTTCATTTAATTCCAGAGTTCCTCAGCCTCAGCAGGTTCTGCTTTTACCTGTCACAGAAATGTCCAGTGTTTAATGCATTTGGTTGCTGGGGCTTACATGCCAGCCTCCTCTGATATGTACTTGGTTTTTAAAAACCCATTTTGTTCTCTCTTGTTTCCTCTCTATTTCAGCCTAGTATCAGAAGGCCAGGCGAGACTGCAACACTGCTCATCACCCCGCGGCGTGATCCCTGCTCTTAGGTGCTGGGCAGAGGGGAAGGGTGGTCAGGGTGAGGATGGTGAGGGAGGGCTGGTGAGGGGCTCAGAGGAATACTTGGAACAACAGCAGTGTTATTGTAGTGTGGCAGTTTCTTTTATACATAGGTGAGAGTTTTTAAAGTGTAAGGGAAAAATTAATTTTTTAAAAAACACCATGCTTGGAGGGTGGGGGTAGAAATAGACACAATATTATTTCTAAGGAATCGGGTTTTCATTTACTCTGGACTGGTGAAAATATTTTTTAAAGCCAGTGCTCTAAGACCTCAGCTTTTATCTCAGAACCCCATGGGTTCCAGACCAAGAGTACAGGAAATCAAATTGTTGTCCTGTCTGTCTATAGCTTGGAACAGGGAGCTTTGATTACTGACTCCGGTTCCACACACTGTAAGATCAAAAAACCATCTCCACATTTGAAAGAGATGTAAGGTGTATTCATAGGGATGGTGGCTCAACAAATCAAGCAAACTGGAATCaaggggagggggaagggaatgaaatggaaagggaGGCTGATTCCCTTCCCCTGACTTACCACTAATTTACTAGGCTACCTACTTTCATGAGTAACCTCTCACAGCTACCCAGCACATGCCACAATCCTATGCTCTTGCCTTCTTTTATCTGCACTGTGTGAAGGGACTCTTTTAAATAAATGAGCAAGTGTCCTAAGCTATGTCATCCAAAGATTGTCCTTTCCATTCTCAAATCCTGTGACTGGGATCACTCAACAGCACTGTGATGTATTATTTTCAATGAGGTGCCTTTCTTAACTGACCAAATGCTGCCTTGTTTGGCCCCTAAATCAATAAAATATGTTAAAATTTGTATCCCCTGTTGTGGCATTTTTTTTAGATAATCTAAGCTAGAAAAATGACATTGAATTCTGGACCTGGCTGGAAGGAAAAGAAGCCCTTTCTTGTCGCTGGCAGCTGTGTGGTAGGGAGGTCCAAGTATGTGCATATGAGATAAGCCTGCAACCTCTTGACCTTCAGCTCCTATGCAGGCTTCTCTTGAGCCcagagacaaggcagcttggtctagtggagatagcactgtgcttggagttcaggggacctaggacaaatcccagccagttagttattcactgtgctcctgtttcctcagctgaaaaaggaagttggttatgccaccttcttggccttaatggcattaaatgaaatttataggaagaaggtttttgctcagtacctggcatgcaacagacattggataaatgttagttGGATCCAGATATACACAGAAAGATATCTGCTTCCTGCCAGGCTGGATAACTGTTGAATGGACACTTGTCCATAGTCTAGAAAGCCAGTGCTTCTAATCCTTAAGCCAGATCTTTGACTACCTTTTCAGTTGCTTCTTTAACACTCTTTGTTGCTTCTCTGTGTGTCCTAGTTTAAATTCATTTCCTCTCCAGCAAAAGTGAGCTTAAATAATTTCTCCAAACTAAAGCTCTCATGTTTTTGGAAGGGCTGCCTTTGCAAGTGAGGTTTCTGAGAAATGACTGTTGTTCCCAAAACAAGAGGGAGCTGGGCTGGAAGCACCACTATTCTTCTTTAGGCATCTTGTTACAGAGAGAGGCAGGGTCTTCACTGACATATTAAATCCTGTTCCCTGAACCAGCCCCTCCCTCTTCTGCTCCACTTCCTCACCTGTGCAGAGTCATTTTCAGGTGTTAGCCTTACTGATTTGCACTGATCTGTTTGTTCCCTGAGCTTTTTAAATACCCTGTGAAAATTTTCTTTCCTCCCTTGGTCATCATGCATCTAATTGTGGGGAAATGTTTGTCAAACCAACCTGCAAAGCAGCATGGTGTAGTTGAGAAGAATAAACAGAGAAGACTGGGTGAGCTATTGTTTGTTTGCTTCTTTGGGCCTGGGTTTCCTCATCTAATCTGCAAACCAAGAATGCAGACTAGTCctaccactcccggaagactgacgttgtgccaggtattatgcaaaggcttcatgtaaccctcgacttcacgtaaccctcacacagcaccctgtggagtcagaactgtccttcacttttataggtgaggaaaccagactcagagaggtgaagtggcattcctgaggtcatgcataagaggcagtcaggactgaaacacagtctctaacacttatccgtccccttGATCTTGTTGCTGAAGTGATTTAATTACTTGCGTAGCTCTGCACACAGGAAGGGCTGCTCTGAATAAGAGCTCTTTTCCATGGACACTCAGCGCTGCCGGAACTGAttttgaagaagtcactgccggctctgagggcctagggtatgtgtcttaggatctcctgtgtgcacaaagtgtcactgacagaacacagcaggatggagagcagcctcctcagaagcctcacaagtctttcctcagatgaagacagagcaacgagtcagaagacagatttcaacagcgacttcaccatgcgaccttggacaagttatctcacctcatcagtagaataggaatgatccctacccctcaaaggtgctgatgacactagtgaccaagatactcatgtGGGTTGGACTGCCCAGGACACAGCAGATGCTTAGTAAACACAGATGGAATTCAGAGGGAAAATGTAGGCATTGAAGAAAGTTGTCTTACTGACCATCCGGAACCAGGCTAAGGATCCCCTAGAAATCATAGACCTCTGAAATTATATGCAGAATTCTTTATGTGTTTTCATAATTaataatagtctaacatattaaattcttagctgtgtga

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