Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name H2AZ2P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:92733615-92734276  UCSC
Coordinates (T2T) chr15:90495891-90496545  UCSC
Coordinates (hg19) chr15:93276845-93277506  UCSC
Strand -
Parental Sequence NM_012412.5
Parental seq. overlap 571 bp
Parental seq. overlap (%) 18.8%
Genomic Region Intergenic
Retrocopy Summary H2AZ2P1, located on chr15:92733615-92734276, is a retrocopy of the parental gene H2AZ2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name H2AZ2
Full Name H2A.Z variant histone 2
Also known as H2A.Z-2|H2AFV|H2AV
Coordinate chr7:44826889-44848126
Strand -
Gene summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes H2AFVP1
Bonobo Pan paniscus LOC100974682P1
Gorilla Gorilla gorilla LOC101152776P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>H2AZ2P1
AGAACATGGCCGGAGGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAGGCTAAGGCAGTATCTCGCTCACAGAGAGCTGGGCTACAGTTTCCTGTGGGCCGCATCCACAGACACTTGAAGACTCGCACCACAAGCCATGGAAGGGTGGGTGCCACTGCTGCCGTGCACAGGGCTGCGATTCCGGGGTACCTCACTGCAGAGGTGCTGGAGCTGGCAGGTAATGCTTCTAAGGGTCTCAAAGCAAAGCGTATCACTCCGCGTCACTGGCAGCTTGCAGTCCGTGGTGATGAAGAGTTGGATTCTCTTATCAAGGCTACCACAGCTGGGGGTGGCGTGATCCCCTCACATCCACAAATCTCTGACTGGAAAGAAGGGACAGCGGAAAACTGCTTAGAGGGATGCTTTAACCAACCCTCTTCCTCCCCGTCATTGTACTGGAACTGGGACAGAAGAAATAATGGGGATATGTGGAATTTTTAACAACAGTTAAATGGAAAAGCATAGACAATTACTGTAGACATGATAAAAGAAACATTTGTACGTTCTTAGACTCGAAGTTTGATAAAAGTACCTTTTCATGTGGTGAAGAGAg
>NM_012412.5
ACGGGGTATTGTCcggctccggcggcggcggtcggtgctgcgagagcggcggcggcggcgcgggtcggcagcgggagggcgcgcggccgagcggaggcggagtcggcgccgAGAACATGGCTGGAGGCAAAGCTGGAAAGGACAGTGGGAAGGCCAAGGCTAAGGCAGTATCTCGCTCACAGAGAGCTGGGCTACAGTTTCCTGTGGGCCGCATCCACAGACACTTGAAGACTCGCACCACAAGCCATGGAAGGGTGGGTGCCACTGCTGCCGTGTACAGTGCTGCGATTCTGGAGTACCTCACTGCAGAGGTGCTGGAGCTGGCAGGTAATGCTTCTAAGGATCTCAAAGTAAAGCGTATCACTCCGCGTCACTTGCAGCTTGCAATCCGTGGTGATGAAGAGTTGGATTCTCTTATCAAGGCTACCATAGCTGGGGGTGGTGTGATCCCTCACATCCACAAATCTCTGATTGGAAAGAAGGGACAGCAGAAAACTGCTTAGAGGGATGCTTTAACCAACCCTCTTCCTCCCCGTCATTGTACTGTAACTGGGACAGAAGAAATAATGGGGATATGTGGAATTTTTAACAACAGTTAAATGGAAAAGCATAGACAATTACTGTAGACATGATAAAAGAAACATTTGTATGTTCTTAGACTCGAAGTTTGATAAAAGTACCTTTTCATGTGGTGACAGTTGTGTGTTGATTGGCTAGGTTTCTCCCGTGTGTTTTATACAAAAATGGAATTGATAAACCATTTTTTACAAAATTAATTTGTCTCAAAACTGTTCTGTTCATGATGTATTAGAAATATTTTACTCAGACTTTAAATATTTTAAATCTCAGATTGGTTATTCAGAGTAACCTTAGAACAGAAATTGGGAATATATCTTTACAATGATTGATACCATGGTATattgactcttagatgctattgatctgtagcaccattttttacaaacgactaaggaaaaaacctgccaattaaatcatgatatgccatcaattatgagacatcccaatttgagagatgttagattatagaaaagtatgcatttATGACTGAAATGGTAGTGGAATTATTTGAATTCTACaccaagcacttaccatgtgccaggccctttgcagagtgctCTACTGACCAAGAAAGTTGTTGCTGccacattatagatgtggagcctaagggtcacagaaattgtgtgctatgccaaaaaacattgaactggtagatagaaaatgacagagctaggattcaaacctagatctggctgactccagagccTAGTTTTACCTGGAATTGATGTTCAGTTTATCAAAGGTTTCTCCTTTTGGTTTAAAATCCCAATTTTTggcctggcattgtggtttacgcctgtaatcccaacacttcgggagaccgaggctggtggaacacttgaggtcaggagtttgagaccagcctggccaacatggtaaaacgccgtctcggccaggcgcggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggtgaatcacgaggtcaggaaatcgagaccatcctggctaacatggtgaaaccccgtctctatttaaaaaaatacaaaaaattagccgggtgtggtggcacgcgcctgtagtcccagctactcaggaggctgaggcatgagaatgacgtgaacccgggaggcggagcttgcagtgagccaagatggcgccactgcactccagcttggcgactgagcaagactccctctcaaaacaaacaaaaaaaagtctctactaaaaatacagaaattagccaggcatggtacacacatgttgtcccaactacttggggcactggggcacaaaaaatcacttgaacccaggaggcagaggttgcagtgagccaagatcacgccactacactccagcctaggtgacagagtgtgactctgtctcaaaaaaaaaaaTCCCAACTTTTAGTAGTCTCTTAGTCATGCAATAACAGTAATTTGTACAATCTTTTAAAAATTATATTTATTTATCAGTTTCTAAGAAACttttttgtttgttttgagacaggctcttgctcttttgcccaggttgaagtgcagtggcatgatcctggctcactgcagcctccacctctcaggcccaagcaatcctcttacctcagccctgcaaatagctgggaccacaggcacatgccaccatacctggctaattttttttatttatgtaagagacagaggtctccctatgttgcccaggttggtattgaactcctggctcaagccatcctcccaccttggcctcccaaagtactgggattataggcataagccaccatgccctgcGCTAAGTAACTGTTACTTGAGTTAATGTACTAGTTAATTGACCCTTAGAAAATTATATTTTTCTGCTTGCAAGTCTTCATTAAAGAAGGAAATTTTAAAATATTTTATAGTATAATGCTATCCAAACTCAtttttaaaaacattttattatggaaattttcacaaatgcacaaaaagaatagcagaatgaagctctgtgtacccatcctccaacagctgtcctgtggtcagtcttgtttacctgcatccccacctatcccctgccccaacccacagggatcagtttgagtcccattaacaggcatagtattttcatgtctgtgtgatcagagacattcaaatataactccaaagatagggtacttttttgaacataaccacaataccattgtgtaagactgctaaaacattttttgatgccaagtaccagtcaatattcaaacttcctgattgtctcgtaagttttttttaacagttggtttattcgagtcaagatccaggcaagatctagatcttgcattttgttaatataatctatagatttaactttcctgtttttaatttttgaagaaactaagttgtttgtcctatagaattgtccttcagtggattttactgaatgtatcctaatgggatcatgtacaccttttctgtcccctatatgttctataaactgacagatctagaggg

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