Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBAP12
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:96388216-96388459  UCSC
Coordinates (T2T) chr15:94152790-94153033  UCSC
Coordinates (hg19) chr15:96931445-96931688  UCSC
Strand -
Parental Sequence NM_080386.4
Parental seq. overlap 200 bp
Parental seq. overlap (%) 13.2%
Genomic Region Intergenic
Retrocopy Summary TUBAP12, located on chr15:96388216-96388459, is a retrocopy of the parental gene TUBA3D. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBA3D
Full Name tubulin alpha 3d
Also known as H2-ALPHA|KTCN9|TUBA2
Coordinate chr2:131476119-131482934
Strand +
Gene summary This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton. Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle formation during mitosis. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBA3CP4
Bonobo Pan paniscus LOC100993591P2
Gorilla Gorilla gorilla LOC101136583P2
Orangutan Pongo abelii TUBA3EP2
Gibbon Nomascus leucogenys TUBA3EP1
Green monkey Chlorocebus sabaeus LOC103247857P3
Crab-eating macaque Macaca fascicularis TUBA8P1
Rhesus Macaca mulatta TUBA3EP1
Baboon Papio anubis TUBA8P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBAP12
CACCCTCAGGACCAACCACAGCATCCACTTTGTGGATTGGTGTCCCACTGGCTTCAAGGTTGGCATCAATTATCAGCCTCCCAATGTGGTACCCGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGTATGCTGAGCAACACCATTGCCATTGCTGAGGCCTGGGCTCACCTGGACCACAAGTTTGACCTCACATATGCCAAGTATGCATTTTTTCACTGGTACATGGGTGAAGGGATGGAT
>NM_080386.4
AGGTTGCAGTTGGGCGCTCAGCAGCTGTGGCAGCCGGTTGAGGTCTGGCAGTAGCGTTGGGCTGAAGCAGCGGAGTTCGCCATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGCTGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGCCAAATGCCAAGTGATAAAACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAGCACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACAGGGACCTACAGGCAGCTCTTCCACCCGGAGCAGCTGATCACCGGGAAGGAAGATGCAGCCAATAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGACCGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGCTTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGATTACGGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCCGTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGTGCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAACGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACAGCCTCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTGCCGTACCCCCGCATCCACTTCCCCCTGGCCACCTATGCCCCAGTCATCTCAGCTGAGAAGGCCTACCACGAGCAGCTGTCTGTGGCCGAGATCACCAATGCCTGCTTCGAGCCAGCCAATCAAATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGGGGGGACGTGGTCCCCAAAGACGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACCATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCCACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAACACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGACCATAAGTTCGATCTCATGTATGCCAAGCGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAGGCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTATGAAGAGGTGGGCGTGGATTCCGTGGAAGCTGAGGCTGAAGAAGGCGAAGAATACTGAGGGGAGGGTGTGGTGGGTTCTCCCCTGCCACCCCCGGGATGGCTGCTTCCAAGTTGTTTGCAATTAAAGGTTCTGTATAAAACCAA

Publications

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