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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CKS2P2
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr15:96551384-96551923  UCSC
Coordinates (T2T) chr15:94316097-94316636  UCSC
Coordinates (hg19) chr15:97094614-97095153  UCSC
Strand +
Parental Sequence NM_001827.3
Parental seq. overlap 386 bp
Parental seq. overlap (%) 58.6%
Genomic Region Intergenic
Retrocopy Summary CKS2P2, located on chr15:96551384-96551923, is a retrocopy of the parental gene CKS2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CKS2
Full Name CDC28 protein kinase regulatory subunit 2
Also known as CKSHS2
Coordinate chr9:89311195-89316703
Strand +
Gene summary CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CKS2P2
Bonobo Pan paniscus CKS2P2
Gorilla Gorilla gorilla CKS2P1
Orangutan Pongo abelii CKS2P3
Gibbon Nomascus leucogenys CKS2P2
Green monkey Chlorocebus sabaeus CKS2P2
Crab-eating macaque Macaca fascicularis CKS2P1
Rhesus Macaca mulatta CKS2P1
Baboon Papio anubis CKS2P1
Golden snub-nosed monkey Rhinopithecus roxellana CKS2P1
Marmoset Callithrix jacchus CKS2P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CKS2P2
TATCTGACGTCTGAAGAGGAGTAGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATGACATGATTCATGAGCCAGAACCACATATTCTTCTCTTTAGACAACCTCTTCCAAAAGATCAACAAAAATGAAGTTTATCTGGGAATTGTCAAATCTTTTTCAAATTTAATGTATATATGTATATAAGGTAGTATTCAGTGAATATTTGAGAAATGTACAAATCTTTCATCCATACCTGTGCACGAGCTATATTCTTCACAGCCACAGAGtGTAGCTTAAATACAACTGCAGTAGCTAAATACAACTGCAAGTTAAATACAGCTGCAAGTAGGTTACCGTAAGATGTTTAAGATAAAAGTTCTTCCAGTCAGTTTTTCTCTTAATGTAAGTGCCTGTTTGACTTTACCTGTTACTTTCGTTCAATAAAGTTTGTGTGTTTCATTTA
>NM_001827.3
GTTAGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCAGCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTTCCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGATTCATGAGCCAGAACCACATATTCTTCTCTTTAGACGACCTCTTCCAAAAGATCAACAAAAATGAAGTTTATCTGGGGATCGTCAAATCTTTTTCAAATTTAATGTATATGTGTATATAAGGTAGTATTCAGTGAATACTTGAGAAATGTACAAATCTTTCATCCATACCTGTGCATGAGCTGTATTCTTCACAGCAACAGAGCTCAGTTAAATGCAACTGCAAGTAGGTTACTGTAAGATGTTTAAGATAAAAGTTCTTCCAGTCAGTTTTTCTCTTAAGTGCCTGTTTGAGTTTACTGAAACAGTTTACTTTTGTTCAATAAAGTTTGTATGTTGCATTTA

Publications

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