Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name GMNNP1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:16539736-16541635  UCSC
Coordinates (T2T) chr16:16551976-16553875  UCSC
Coordinates (hg19) chr16:16633593-16635492  UCSC
Strand -
Parental Sequence NM_001251990.2
Parental seq. overlap 494 bp
Parental seq. overlap (%) 44%
Genomic Region Intergenic
Retrocopy Summary GMNNP1, located on chr16:16539736-16541635, is a retrocopy of the parental gene GMNN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GMNN
Full Name geminin DNA replication inhibitor
Also known as Gem|MGORS6
Coordinate chr6:24774937-24786099
Strand +
Gene summary This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GMNNP1
Bonobo Pan paniscus GMNNP1
Gibbon Nomascus leucogenys GMNNP1
Crab-eating macaque Macaca fascicularis GMNNP1
Rhesus Macaca mulatta GMNNP1
Golden snub-nosed monkey Rhinopithecus roxellana GMNNP1
Marmoset Callithrix jacchus GMNNP1
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GMNNP1
AGTTTACCTCCAGTATAGTTCTTTAAAGCAGAACACATAACTACATAATGCAACCTCTGAGATCAAAATTCTTTGTTTGAATCCTGGGACCCTACTGTATTAAAATATAAACACTGTATATTTTTAATTTATGATGTTTTATGTGAACAGCATTTTCTCAATTGTCAGACATGACTTGTGTAATTGACTAAAGAAACTTCAATCTCCTATTGAAAAAGTCTTACATGTTAAACCTATTAATATTTGACTCTTGAGAAATATATTGTCCCAGAATAGAGTGACAATTAAAATCTTGGAGGAGTCACCCAAGAAGCATTTGATTTTAGGATTAAATGAAATTTATCCCCTCAATATTGGAGAGAAGTAGCAGAACAAAGGAACACCCTCTATGAAACACTTAAGGAAAATGAGAGGCTTCACAGAGAAATTGAAGAAAGAACAATGAAATTGACCACTTGGAAAAGGAGAGTAAACAATTGGCAAAAGCGGCAGAGTACAGTATATGACAGAGGCAACCCAGAGACTGAATGATGAACCTCTGGATAACTCTGAAGCACCAGATAGTCAGGAATTTGATTCTGAAGAGAAAACTGGTGAAGATTCTCAAGTGGAAAACCCAAAAATTGGCACATGCACTGAGAATCCTGTCTTCCTCTACAGATGCAAAACCTTGCACGTAAAATTTAGGa
>NM_001251990.2
GTCAGTTGGTCACGTGGTTGTTCGGAGCGGGCGAGCGGAGTTAGCAGGGCTTTACTGCAGAGCGCGCCGGGCACTCCAGCGACCGTGGGGATCAGCGTAGTCTTCTGTGCTTCACCATCTACATAATGAATCCCAGTATGAAGCAGAAACAAGAAGAAATCAAAGAGAATATAAAGAATAGTTCTGTCCCAAGAAGAACTCTGAAGATGATTCAGCCTTCTGCATCTGGATCTCTTGTTGGAAGAGAAAATGAGCTGTCCGCAGGCTTGTCCAAAAGGAAACATCGGAATGACCACTTAACATCTACAACTTCCAGCCCTGGGGTTATTGTCCCAGAATCTAGTGAAAATAAAAATCTTGGAGGAGTCACCCAGGAGTCATTTGATCTTATGATTAAAGAAAATCCATCCTCTCAGTATTGGAAGGAAGTGGCAGAAAAACGGAGAAAGGCGCTGTATGAAGCACTTAAGGAAAATGAGAAACTTCATAAAGAAATTGAACAAAAGGACAATGAAATTGCCCGCCTGAAAAAGGAGAATAAAGAACTGGCAGAAGTAGCAGAACATGTACAGTATATGGCAGAGCTAATAGAGAGACTGAATGGTGAACctctggataattttgaatcactggataatcaggaatttgattctgaagaagaaactgttgaggattctctagtggaagactcagaaattggcacGTGTGCTGAAGGAACTGTATCTTCCTCTACGGATGCAAAGCCATGTATATGAAATGCATTAATATTTGACTGTTGAGAATTTTACTGCCGAAGTTTACCTCCACTAGTTCTTTGTAGCAGAGTACATAACTACATAATGCCAACTCTGGAATCAAATTTCCTTGTTTGAATCCTGGGACCCTATTGCATTAAAGTACAAATACTATGTATTTTTAATCTATGATGGTTTATGTGAATAGGATTTTCTCAGTTGTCAGCCATGACTTATGTTTATTACTAAATAAACTTCAAACTCCTGTTGAACATTGTGTATAACTTAGAATAATGAAATATAAGGAGTATGTGTAGAAAA

Publications

PMID - Link Title