Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPRP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:61654192-61655518  UCSC
Coordinates (T2T) chr1:61533080-61534406  UCSC
Coordinates (hg19) chr1:62119864-62121190  UCSC
Strand +
Parental Sequence NM_003124.5
Parental seq. overlap 1147 bp
Parental seq. overlap (%) 79.3%
Genomic Region Intergenic
Retrocopy Summary SPRP1, located on chr1:61654192-61655518, is a retrocopy of the parental gene SPR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPR
Full Name sepiapterin reductase
Also known as SDR38C1
Coordinate chr2:72887408-72892158
Strand +
Gene summary This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SPRP1
Bonobo Pan paniscus SPRP1
Gorilla Gorilla gorilla SPRP1
Orangutan Pongo abelii SPRP1
Gibbon Nomascus leucogenys SPRP1
Green monkey Chlorocebus sabaeus SPRP1
Crab-eating macaque Macaca fascicularis SPRP1
Rhesus Macaca mulatta SPRP1
Baboon Papio anubis SPRP1
Golden snub-nosed monkey Rhinopithecus roxellana SPRP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPRP1
CCTCCTGGCCTCGCTGCTGTCGCCGAGCTGCATGCTGGTCCTCAACGCCCGCAACGACGATGCGCTGCGGCAGCTGGAGGCCGAGCTGGGCGCCGGGCGGTCTGACTTGCGCGTCGTGCGGGTGCCCGCAGACCTGGGCGCCGAGGCTGGCTTGCAGCCCGCTGCTTGGGGCCTTGCGTCAGCTCCCCAGGACCGAGGAGCTGCAGCAACTGCTCTTCATCAACAACGCGGGCTCTCCTGGGGATGTGTCCAAAGGCTTCGTGGACCTGGGTGACTCCACTCAAGTGAACAAAGACTGGGCGCTGAACTTGACCTCCATGCTCTCTCTGCCGGACTTGCAGCGTCTCGAAGGCCTTACCAACCAGTCCTGGCCTCAACAGAACTGTGGTTAACATCTCAACCCTCTGTGCCCTGCAGCCCTTCAAAGGCTGAGCGCTGTGCTGTGCGGGAAAGGCTGCTGGTAACATTCTGTTGAGGTCCTGGCGTCGGAGGAACCTAATGTGAGGGTGCCGAATTAGGCCCCAGGTCCTGTGGACACAGACGTGTCCCGGAGGTTAGCCCGGTAGACCTCCATGGACCCAGACATGCGAAAAGGCTGCAGGAGCTGAAGGCAAAGGGAGAGCTGGTGGATTGCAGGGTGTCAGCCCAGAAACGGCTGAGCTCGCTGCAAAAGGGGGTGTTCAAGCCTGGAGCCCACGTGGACTTCTACTATAAATAAGCCCATGTCTTTGGCTTCCTGAACCTTTCTGCCCCCACTTTCAGACACACCCCCAGAGCCCCGTGGCTCCCCACACCCTGCCATGGTGGCAGTCCTGCCTTACACAGATAAACACTCATGTCTACTGTCCTACCTTCACACATAGCCTGCTGTGATGAGCTTCCAGGTCGCTGGCCTTACCAGTTGTCGAGAGTCTGGATGTGGCACCCTGGATTATGAGGAGGCTTAGGAGAGAGGTTATGGGTATTCATGTCTCTATCCCCAGGAATAGAATTTAAGGGATGGGAAGAGCAGGAAAAGAAGCTGAAACACACAAGAGAAGAGGTTGTGTCTCCTGCTCATAGCTAGTCCATGGGGAGAGGGAAGAGTGACCTGAGTCAAATAGGAGAACGCATGCAGATTCGCAGATGGCCTGGTAGGGAGGAAGAGCAGAGGGTACAAGTCCCCGCTCACACAGATGCCCCTTGCTGAGGGGAGCAGCAGCTTCTGTTGAACTTTGTGTCCTCACTCTGATGTCTACTTCCTCCAGAATCCACCACCCCTTCCCCAGGCTGGGAGAAGGGGCCGTTGGGTGTCTATGTACATGGCCAAGGCAG
>NM_003124.5
AGCGCCGCCGGCGGAGAACAGGAGCATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGCCGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGCGCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGCCTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTCGGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAACGCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTGAACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAGGCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCCCTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTGTTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCTCTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAAGGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAACTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGACAAATAAGCCCATGTTTTTGGCTTCCTGAACCTTTTTGCCCCCACTTTTAGACATACCCCAGAGCCCTGTGGCTCCCCACACCCTGCCATAGGGGCAGTCCTGCCTTACACATAGAAGCATTCATGCCTGCTGCCCTGCCCTCAGGCACAGCCAGCTGTGAGCTCCCAGGTCATTGGCCTTACCAGTTGTCAGGAGTCTGTGCTGTGCACCCTGGGTTATAAGGAGGCTTAGGAGAGAGGTTATGGGTATTGGTGTCTCTATCCCCAGGAATAGAACTTAAGGGGTGGGAAGAACAGGAAAAGAAGCTGGAACACAGAAGAGAGGAGGTTGTGTCTCTTGCTCATAGCAAGCCTGTGGGTAGAGGAAAGAGTGATCTGGTGTCGAATAGGAGGACCCATGTAGATTCGCAGATGGCCTGGATGGGAGGAAGGGCAGACGGTACATGTCCCAGCCCACATAGATGCCCCTTGCTGAGGGTAGCAGGACCTTCTGTTGAACTTTGTGTCCTCACTCTGATGTCTCCTTCCTTCAGAATCTACCACCCCTCCCCCAGGCTGGGAGAAGGGGCTCCTGGGTGTCTGTATACACGCCAAAGGCAGATACAAATAAAATACAGATTGTCCTTTC

Publications

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