Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDCA8P2
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:21978842-21980298  UCSC
Coordinates (T2T) chr16:22236892-22238346  UCSC
Coordinates (hg19) chr16:21990163-21991619  UCSC
Strand +
Parental Sequence NM_018101.4
Parental seq. overlap 520 bp
Parental seq. overlap (%) 22.6%
Genomic Region Intragenic (PDZD9)
Intragenic (UQCRC2)
Retrocopy Summary CDCA8P2, located on chr16:21978842-21980298, is a retrocopy of the parental gene CDCA8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDCA8
Full Name cell division cycle associated 8
Also known as BOR|BOREALIN|DasraB|MESRGP
Coordinate chr1:37692516-37709719
Strand +
Gene summary This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CDCA8P3
Bonobo Pan paniscus CDCA8P3
Gorilla Gorilla gorilla CDCA8P3
Orangutan Pongo abelii CDCA8P3
Gibbon Nomascus leucogenys CDCA8P1
Green monkey Chlorocebus sabaeus CDCA8P1
Baboon Papio anubis CDCA8P4
Golden snub-nosed monkey Rhinopithecus roxellana CDCA8P5
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDCA8P2
GGAACTGGCTTGACTACTTCACCCTTGGTGAAAACAAACAGGCCCTAAAAGAGGCAGCAACAGCTGAAGTGGATATCACAGAAATAAACAGACAGCAGAAGCTCTTCAGACACCCCCGAAACCTGCCAAAACTCACAGGTAATACAAGTGAAACGATAGCATAAGAAGAAAATAAACATGAGAATCTTCAAACTACAAGCATTGAACGGTATCCTCCATCCAAGAAGAGAACCCACTTCATACAAGGAAAAGGCAAAAGGAAAAGGTCAAGACTGTGACCTTTATAACACTGTGACCCCAGCTGTGGGCCAGGTGGAGTTGTCTGTGGTGACACCAAGTACAGGCCTGACACCCTGGTTTGACAGAAGGCTCTTCAAGATCCCTGGTCTTCACACTGTAGCAGCCAAAAGGTAGGTTTACAATATACtGCCATCTCAGTGGATGACAGCCTTCTCACTGACAGCAGAGAGATCTTCCTCACTGTGCCAGTGGGCAGGAGAAAGAGCATGCTGCGACTGGCCAGTGACATGCAGAGGATCCAGATTGCACAACCGGATCCAGAGGCCTTGGGAAGCATTAGGGAGCTCTCCAGCTGTCTCACTCAAATCTGTAGCAGCATATGGACCCACAAATG
>NM_018101.4
GTAGAGCCGCTCTCTCTCACTGGCACAGCGAGGTTTTGCTCAGCCCTTGTCTCGGGACCGCAGCCTCCGCCGAGCGCCATGGCTCCTAGGAAGGGCAGTAGTCGGGTGGCCAAGACCAACTCCTTACGGAGGCGGAAGCTCGCCTCCTTTCTGAAAGACTTCGACCGTGAAGTGGAAATACGAATCAAGCAAATTGAGTCAGACAGGCAGAACCTCCTCAAGGAGGTGGATAACCTCTACAACATCGAGATCCTGCGGCTCCCCAAGGCTCTGCGCGAGATGAACTGGCTTGACTACTTCGCCCTTGGAGGAAACAAACAGGCCCTGGAAGAGGCGGCAACAGCTGACCTGGATATCACCGAAATAAACAAACTAACAGCAGAAGCTATTCAGACACCCCTGAAATCTGCCAAAACACGAAAGGTAATACAGGTAGATGAAATGATAGTGgaagaggaagaagaagaagaaaatgaacgtaagaaTCTTCAAACTGCAAGAGTCAAAAGGTGTCCTCCATCCAAGAAGAGAACTCAGTCCATACAAGGAAAAGGAAAAGGGAAAAGGTCAAGCCGTGCTAACACTGTTACCCCAGCCGTGGGCCGATTGGAGGTGTCCATGGTCAAACCAACTCCAGGCCTGACACCCAGGTTTGACTCAAGGGTCTTCAAGACCCCTGGCCTGCGTACTCCAGCAGCAGGAGAGCGGATTTACAACATCTCAGGGAATGGCAGCCCTCTTGCTGACAGCAAAGAGATCTTCCTCACTGTGCCAGTGGGCGGCGGAGAGAGCCTGCGATTATTGGCCAGTGACTTGCAGAGGCACAGTATTGCCCAGCTGGATCCAGAGGCCTTGGGAAACATTAAGAAGCTCTCCAACCGTCTCGCCCAAATCTGCAGCAGCATACGGACCCACAAATGAGACACCAAAGTTGACAGGATGGACTTTTAATGGGCACTTCTGGGACCCTGAAGAGACTTCTTCCCTTCAGGCTTATTGTTTGAGTGTGAAGTTCCAGAGCAAGGAGCCATGTTCCTCTAAGGGAATTCAGGAATTCAGACGTGCTAGTCCCACACCAGTTAGGTAGAGCTGTCTGTTCACCCTCCCATCCCAGCTGATCCCAGTCACTGCTTGCTGGGGCCATGCCATGGAAGCTTCCCATCAGTCTCCCAGCTGAATCCTCCCTGCTCTCTGAGCTGCTGCCTTTTGCCTCCTGCAACTCAACATCCTCTTCACCCTGCCCTGCCTGCAGTTGAGGGGGCGAAGAAGAACCCTGTGTTCTCAGGAAGACTGCCTCCACCACCGCTACCCAGAGAACCTCTGCATCTGGCATTTCTGCTCTCTATGCTTGAGACCGGGAGGTTTAGGCTCAGATAAGTGAGCTCTGGGCCATGAGAGGGTAGGTCCAGAAGGTGGGGGGAACTGTACAGATCAGCAGAGCAGGACAGTTGGCAGCAGTGACCTCAGTAGGGAACATGTCCGTCTACCCTCTCGCACTCATGACAcctccccctaccagccctcctcttcctcctcctcctcctcctGTGGGAGGTGGTCAGTGGGACTTAGGGATCTTTCACCTGCTGTGCCCAGTAGTTCTGAAGTCTGCTTGTGGAGCAGTGTTTTATGTTTATCCCTGTTTACTGAAGACCAAATACTGGTTTGGAGACAACTTCCATGTCTTGCTCTTCTACCTCCCTAGTTAGTGGAAATTTGGATAAGGGAACTGTAGGGCCCAGATTCTGGAGGTTTTATGTCATTGGCCACAGAATAACTGTCTCTAAGCTATCCATGGTCCAGTGGTCCCTGCCAAGTCTGTAGACTTCAGAGAGCACTTCTCTCTTATGGGGTTCATGGGAACAGGGGTGGGTGTGACTTGCTTGGTGGCCTCATTCCATGTGTGCCTGTGCCTGGGGCATGGACTTTGTTAAGCAGAGTCAGCAGTGAGGTCCTCATTCTCCAGCCAGCCTCTCTGCCCTGGAGAATCATGTGCTATGTTCTAAGAATTTGAGAACTAGAGTCCTCATCCCCAGGCTTGAAGGCACATGGCTTTCTCATGTAGGGCTCTCTGTGGTATTTGTTATTATTTTGCAACAAGACCATTTTAGTAAAACAGTCCTGTTCAAGTTGTATTCTTTTAAGTTCTTTTATTCTCCTTTCCCTGAGATTTTTGTATATATTGTTCTGAGTAATGGTATCTTTGAGCTGATTGTTCTAATCAGAGCTGGTACCTACTTTCAATAAATTCTGGTTTTGTGTTTTCTTTTGTAA

Publications

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