Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ICA1P1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:21998865-21999427  UCSC
Coordinates (T2T) chr16:22217762-22218324  UCSC
Coordinates (hg19) chr16:22010186-22010748  UCSC
Strand +
Parental Sequence NM_001350820.2
Parental seq. overlap 499 bp
Parental seq. overlap (%) 20.4%
Genomic Region Intragenic (PDZD9)
Retrocopy Summary ICA1P1, located on chr16:21998865-21999427, is a retrocopy of the parental gene ICA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ICA1
Full Name islet cell autoantigen 1
Also known as ICA69|ICAp69
Coordinate chr7:8113184-8262687
Strand -
Gene summary This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ICA1P1
Bonobo Pan paniscus ICA1P1
Gorilla Gorilla gorilla ICA1P1
Orangutan Pongo abelii ICA1P1
Gibbon Nomascus leucogenys ICA1P1
Green monkey Chlorocebus sabaeus ICA1P1
Crab-eating macaque Macaca fascicularis ICA1P1
Rhesus Macaca mulatta ICA1P1
Baboon Papio anubis ICA1P1
Golden snub-nosed monkey Rhinopithecus roxellana ICA1P1
Marmoset Callithrix jacchus ICA1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ICA1P1
CATGCAATCTCCTGTCTCAAATGCTAGCAACATACCAGACCACTCTGCTTCATTTTGGAGAGAAGACTTCTCACACTATGGCAGCCATCCATGAGAGCTTCACAGGTTATCAGCCATATGAAGTCACTACTTTAAAGCACTTACAAAACCCTCTGAAAAAACTAGTTGAGAAAGAAGAAAAGAAGCTCACCCAGCAGGAAAGCACAGATGTAACAGTGCAGGAGCTGAGTCAATTAATTTCATTAGAGGATGAAAACCACGACAAGGAAAACACTGAAGATGGAAAAGGTATTTTATGTGTTTTAGGCAAAGGCTCTTCACACAGTGCATGCTCAGGATGAACTATTAGACATGAAACCTGAGGAAAGTGCTCGCTAGGGCCCAGTGGCAGGGACCCTGGAACCCGAAGGTACTGACAAAGATGATCCTACTGCTGTTGAAAGTGAGATCTTCAATGCTTCCTCCCTGGAAAAGGGTGAGCTCAGAAAAGAGTGAGCTGCTGTGTTTGGGGACAACCAGGTGGAGGAGGCAGCACTATGGTCCTCGGAGAGCCAGACCCCAAG
>NM_001350820.2
GCTGACGTCGGATGAGTGATCCGGAGGGACGCTCCGACCGCGGCCGGGAGGCTCCTGGGGGCCGGGGCTCCGAGGTACCTGCCCTCcggggtcggggcgggggcgcgccgggcgggCTGCAGGAAGCAGCAGGAGACGCCCGGCAGCCGGGACGGTCGGGGACGCCTGGTTATAATATAACTTATCCTCTCATGCTTTTTTCCTGCCCCTTCTCCCCAAATCATCAACAATAGAAGAAGAAGAAAACATGTCAGGACACAAATGCAGTTATCCCTGGGACTTACAGGATCGATATGCTCAAGATAAGTCAGTTGTAAATAAGATGCAACAGAAATATTGGGAGACGAAGCAGGCCTTTATTAAAGCCACAGGGAAGAAGGAAGATGAACATGTTGTTGCCTCTGACGCGGACCTGGATGCCAAGCTAGAGCTGTTTCATTCAATTCAGAGAACCTGTCTGGACTTATCGAAAGCAATTGTACTCTATCAAAAGAGGATATGTTTCTTGTCTCAAGAAGAAAACGAACTGGGAAAATTTCTTCGATCCCAAGGTTTCCAAGATAAAACCAGAGCAGGAAAGATGATGCAAGCGACAGGAAAGGCCCTCTGCTTTTCTTCCCAGCAAAGGTTGGCCTTACGAAATCCTTTGTGTCGATTTCACCAAGAAGTGGAGACTTTTCGGCATCGGGCCATCTCAGATACTTGGCTGACGGTGAACCGCATGGAACAGTGCAGGACGGAATATAGAGGAGCACTATTATGGATGAAGGACGTGTCTCAGGAGCTTGATCCAGACCTCTACAAGCAAATGGAGAAGTTCAGGAAGGTACAAACACAAGTGCGCCTTGCAAAAAAAAACTTTGACAAATTGAAGATGGATGTTTGTCAAAAAGTGGATCTTCTTGGAGCGAGCAGATGCAATCTCTTGTCTCACATGCTAGCAACATACCAGACCACTCTGCTTCATTTTTGGGAGAAAACTTCTCACACTATGGCAGCCATCCATGAGAGTTTCAAAGGTTATCAACCATATGAATTTACTACTTTAAAGAGCTTACAAGACCCTATGAAAAAATTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAGGAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACTGCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAAGGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCTGTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTTCCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGTACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAATTATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTGTATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGCGGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGCAGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCCTGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTCTCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACAAACCTTACTATGGAAAGCAGCCATATTTGCAGATACCACTGTCTCCTTTTGTCCTCTTCGTGGCTGGAATTCAAAAGCATGTATTTCTGAAGCCTCTTGTGACAttgttttttttttttttttAATTAAACAGAAAAGATATTTGACATGCAAA

Publications

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