Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDC37P2
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:28414465-28414851  UCSC
Coordinates (T2T) chr16:28694784-28695170  UCSC
Coordinates (hg19) chr16:28425786-28426172  UCSC
Strand +
Parental Sequence NM_007065.4
Parental seq. overlap 320 bp
Parental seq. overlap (%) 19.7%
Genomic Region Intergenic
Retrocopy Summary CDC37P2, located on chr16:28414465-28414851, is a retrocopy of the parental gene CDC37. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDC37
Full Name cell division cycle 37, HSP90 cochaperone
Also known as P50CDC37
Coordinate chr19:10391128-10403568
Strand -
Gene summary The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla CDC37P2
Orangutan Pongo abelii CDC37P2
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDC37P2
CTACCTGGTCATCTGGTGTGCTGATCTAGAGGTGCAGGAGAAATGCGCCCTCATGGAGCAGGTGGTCCACTAGGCAATTGTCACGCAGTTCAACCTGGTGTTGGTCAGGAGCCGGAAGGGGTCCCCCGGGTCTGCTTCTGGCAGTTCTTCACTGAGATTCAGACGGCTGACTGCTAGTGCATGGAGAGCTTCAAGGACGAGCTGGAAGCCTCCACGGAGCCTGTGTGGGGCTGCGCCAAGCTGCGCGTCTAGAAAGCAGGTGGTGCAGGAGTACTAGGAGGAGGAGCTCAAGAAGCAGCTTGGCCCTGGTGGCCTGGAACCCGTGGAGGTGACGAGTTCCCCCTGAGGAACTCCAAAAGGGCTTCAATGCGAAGGACGCGCAAATGC
>NM_007065.4
AGTCTCCACTGCTGCCGCCGTCGCCGCCACCCGAGCCGGAGCGGGCTGGGCCGCCAAGGCAAGATGGTGGACTACAGCGTGTGGGACCACATTGAGGTGTCTGATGATGAAGACGAGACGCACCCCAACATCGACACGGCCAGTCTCTTCCGCTGGCGGCATCAGGCCCGGGTGGAACGCATGGAGCAGTTCCAGAAGGAGAAGGAGGAACTGGACAGGGGCTGCCGCGAGTGCAAGCGCAAGGTGGCCGAGTGCCAGAGGAAACTGAAGGAGCTGGAGGTGGCCGAGGGCGGCAAGGCAGAGCTGGAGCGCCTGCAGGCCGAGGCACAGCAGCTGCGCAAGGAGGAGCGGAGCTGGGAGCAGAAGCTGGAGGAGATGCGCAAGAAGGAGAAGAGCATGCCCTGGAACGTGGACACGCTCAGCAAAGACGGCTTCAGCAAGAGCATGGTAAATACCAAGCCCGAGAAGACGGAGGAGGACTCAGAGGAGGTGAGGGAGCAGAAACACAAGACCTTCGTGGAAAAATACGAGAAACAGATCAAGCACTTTGGCATGCTTCGCCGCTGGGATGACAGCCAAAAGTACCTGTCAGACAACGTCCACCTGGTGTGCGAGGAGACAGCCAATTACCTGGTCATTTGGTGCATTGACCTAGAGGTGGAGGAGAAATGTGCACTCATGGAGCAGGTGGCCCACCAGACAATCGTCATGCAATTTATCCTGGAGCTGGCCAAGAGCCTAAAGGTGGACCCCCGGGCCTGCTTCCGGCAGTTCTTCACTAAGATTAAGACAGCCGATCGCCAGTACATGGAGGGCTTCAACGACGAGCTGGAAGCCTTCAAGGAGCGTGTGCGGGGCCGTGCCAAGCTGCGCATCGAGAAGGCCATGAAGGAGTACGAGGAGGAGGAGCGCAAGAAGCGGCTCGGCCCCGGCGGCCTGGACCCCGTCGAGGTCTACGAGTCCCTCCCTGAGGAACTCCAGAAGTGCTTCGATGTGAAGGACGTGCAGATGCTGCAGGACGCCATCAGCAAGATGGACCCCACCGACGCAAAGTACCACATGCAGCGCTGCATTGACTCTGGCCTCTGGGTCCCCAACTCTAAGGCCAGCGAGGCCAAGGAGGGAGAGGAGGCAGGTCCTGGGGACCCATTACTGGAAGCTGTTCCCAAGACGGGCGATGAGAAGGATGTCAGTGTGTGACCTGCCCCAGCTACCACCGCCACCTGCTTCCAGGCCCCTATGTGCCCCTTTTCAGAAAACAGATAGATGCCATCTCGCCCGCTCCTGACTTCCTCTACTTGCGCTGCTCGGCCCAGCCTGGGGGGCCCGCCCAGCCCTCCCTGGCCTCTCCACTGTCTCCACTCTCCAGCGCCCATTCAAGTCTCTGCTTTGAGTCAAGGGGCTTCACTGCCTGCAGCCCCCCATCAGCATTATGCCAAAGGCCCGGGGGTCCGGGGAAGGGCAGAGGTCACCAGGCTGGTCTACCAGGTAGTTGGGGAGGGTCCCCAGCCAAGGGGCCGGCTCTCGTCACTGGGCTCTGTTTTCACTGTTCGTCTGCTGTCTGTGTCTTCTATTTGGCAAACAGCAATGATCTTCCAATAAAAGATTTCAGATGCTC

Publications

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