Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PSMB5P1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:47262772-47263720  UCSC
Coordinates (T2T) chr16:53059595-53060543  UCSC
Coordinates (hg19) chr16:47296683-47297631  UCSC
Strand +
Parental Sequence NM_002797.5
Parental seq. overlap 821 bp
Parental seq. overlap (%) 77.7%
Genomic Region Intragenic (ITFG1)
Retrocopy Summary PSMB5P1, located on chr16:47262772-47263720, is a retrocopy of the parental gene PSMB5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PSMB5
Full Name proteasome 20S subunit beta 5
Also known as LMPX|MB1
Coordinate chr14:23025851-23035220
Strand -
Gene summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PSMB5P1
Bonobo Pan paniscus PSMB5P1
Gorilla Gorilla gorilla PSMB5P1
Orangutan Pongo abelii PSMB5P2
Gibbon Nomascus leucogenys PSMB5P1
Green monkey Chlorocebus sabaeus PSMB5P2
Crab-eating macaque Macaca fascicularis PSMB5P1
Rhesus Macaca mulatta PSMB5P1
Baboon Papio anubis PSMB5P2
Golden snub-nosed monkey Rhinopithecus roxellana PSMB5P1
Marmoset Callithrix jacchus PSMB5P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PSMB5P1
ATGCAGATCTGCTGGATCTGGGTCCAGGGAGTCCCACTGATGGGCTGAGGCTGGCCATGCCCAGCTGGGGAGTCTCAGAGGAGCAGGGAATCAAAATGCTTCCTGGAATCACCACCCTGGTCTTCAAGTTCTGGCATGGAGTCATAGTTGCAGCAGACTATAGGGCTGCAGTGGGTGCTTACATTGCCTCCAGATGGTAAAGAAGGTGACAGAGATCAACCCCTACCCGAAGCCATCATGGCTAGGGGCACAGGGAACTGTAGCTTCTGAGAATGGCTGTTGGCTCGGCAAAGTCAAATGTATGAGCTTTGAAATAAGGAATGCATCCCTGTAACAGCTGCCTCCAAGCTGCCTGACAACATATTGTATCAGTACAAAGGCATGGGGCTGTCCATAGGCAACATGATCTGTGGCTGGGATAGGAGAGGCCCTGGCCTCTGCTACATGGACACTGAAGGGAATCAGATCTCAGGGGCCACCTTCTCTGTAGGTTCTTGCTCTGTGTATGCTTATGGGGTTATGAATCAGGGCTATTCCTATAACCTGGAAATGGAGCAGGCCTATGATCTGGCCCATGAGGTAAGCTACCAAGCCATCTACCAAGCCACCTGCATAGATGCCTACTCAGGAGGTGCTGCTAACCTCTACCATGTGCAGGAGGATGGCTGGATCCAAGTCTCCAGTGACAATGCAGTTGATCTTCATGACAAGTATGATGGATCTACCCCAGGAGGGAGGGTGATGTAGCTGTTTGCATTTCTTGGGTGACTGTCATTGGTAATATGGATACAGTGCTTCATCTTATCTCTAGTGGAGGGGTCTTCAACTGTATCAATACTTTTTTTTAAAGCTGTGGAACACTGACCTCTATGTGTTACCAGTCCTTAATGAGCTGCTGCAGAGGTGGCTATTTTACTTTCTTGGATGTTAAGGTACTCTACTCACTACT
>NM_002797.5
CTTTCTGCCCACACTAGACATGGCGCTTGCCAGCGTGTTGGAGAGACCGCTACCGGTGAACCAGCGCGGGTTTTTCGGACTTGGGGGTCGTGCAGATCTGCTGGATCTAGGTCCAGGGAGTCTCAGTGATGGTCTGAGCCTGGCCGCGCCAGGCTGGGGTGTCCCAGAAGAGCCAGGAATCGAAATGCTTCATGGAACAACCACCCTGGCCTTCAAGTTCCGCCATGGAGTCATAGTTGCAGCTGACTCCAGGGCTACAGCGGGTGCTTACATTGCCTCCCAGACGGTGAAGAAGGTGATAGAGATCAACCCATACCTGCTAGGCACCATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGAATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCCAACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGGGATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCCACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCCTATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACCTACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGGATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCCTGAAAGAGGGTGGATGCAGCTGCTTGTGTTTCTTGGGGTGACTGTCATTGGTAATACGGACACAGTGACCCATCCTCCATCCTATTTATAGTGGAAGGGCCTTCAATTGTATCAGTACTTTTTTTTAAGCTCTGGCACATTGACCTCTATGTGTTACCAGTCATTAATGAGCTGCTGCAGAGGTGACTATTTGTTTTACTTTCTTGGATGTTAACATTACACTACTCACTACTcaa

Publications

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