Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPRD1AP1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:50046464-50048627  UCSC
Coordinates (T2T) chr16:55844214-55846377  UCSC
Coordinates (hg19) chr16:50080375-50082538  UCSC
Strand +
Parental Sequence NM_018170.5
Parental seq. overlap 1246 bp
Parental seq. overlap (%) 27.7%
Genomic Region Intergenic
Retrocopy Summary RPRD1AP1, located on chr16:50046464-50048627, is a retrocopy of the parental gene RPRD1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPRD1A
Full Name regulation of nuclear pre-mRNA domain containing 1A
Also known as HsT3101|P15RS
Coordinate chr18:35989824-36067576
Strand -
Gene summary This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPRD1AP1
Bonobo Pan paniscus RPRD1AP1
Gorilla Gorilla gorilla RPRD1AP1
Orangutan Pongo abelii RPRD1AP1
Gibbon Nomascus leucogenys RPRD1AP1
Green monkey Chlorocebus sabaeus RPRD1AP1
Crab-eating macaque Macaca fascicularis RPRD1AP1
Rhesus Macaca mulatta RPRD1AP1
Baboon Papio anubis RPRD1AP1
Golden snub-nosed monkey Rhinopithecus roxellana RPRD1AP1
Marmoset Callithrix jacchus RPRD1AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPRD1AP1
TGTGGGACGGCGTGAATGTGGGGTGGAAGGGATGTCAGTCTTCTCTGAGGCGGCGCTGGAGAAGGAGCTGTCGGGGTTAAGCAATGCGCAGCAGAGCATGCAGACCTGGTCCCTGTGGCTCATTCATCACAGCAAGAAGCACCCGGGCCCGTGGTCACCGCATGGTAGCTGGAGCTGCAGAGAGCAAAGCCAAACAGGAAGCTTACTTTTCTTACCTTGCCAGTGCAAAAGGAAGGGGCCGGAGCTTACAAAAGATTTGCACTGGTTATAGTGGAAGCTTTTAAGCATGTTTCAAGTGAAACTGATGAGAGTTGTAAGAAGCACAGAAGCACATTGGAAGAGTGTTGTCTATTTGGGAAGAAAGGTCTGTTTATGCAAATGATGTATTTAGATGTATTAGAGCAACTTAAGCTCTGTGTGGTGATAAGAAGCCTAGGAAGCAAATTTATAAACAGATAAAGATGAATGAAAATAAAAACTGTTCTTCTCTGGGATCTGCAAATGAGCCACCACCACAGACTCTAAATCTCGTGACAGCATTACAAAATCTAGAAAATGCAGCCTTGGGTGATGCAGGAGTTCACTAGAGGATCACTTTTTTGCCTGCTGTAGACCAAGAAGTATCTCTACTAGATAAAATAGCAGATAAAGAACCTGGAGAAAGGCTTTCTAAAATGATGGATGCATGTATGTTGCCAGCAGATTACAATGGCAGAATGGCAGCAGAAATAGATGAGGGGAAGCAACTCACTCGAATGTTAGCAGATTTTCTTCATTGTCCAATGGAAGCCCTCGCAGAGAAAGCATAAATTGGAAGAATACAAGTGCAAGTGAGCCAGAGTTTCCCTGGTGTGCAAAGAATTCAGGTCCCCGATCCAGAGCCTGTCAGATTAATCTTGACTACCCAATGTCACTGGCAGCCGCATGCACCTGCCCTTTGCAGGGACATCTACAGTGAAGATTAATGGACCAGCCTCTTTCCCGGTCCCAAGACTGCAAGAGGTGGAGACAGGTGGATAGTCCTGTAGTGGTATTTTTGCATATTTTTGAGAGAGAAACACTAGCAAAATAAATGACAATTAGTAAAAATGTTTGAAATGTTGGTTTGTTTACTATTTTCTTTATAAGTTAACATGAATTAGTTTTGGGGTGGTGGGGATGCACCTGACCTATGACTTCGTTTAAACAAAGTGATGGGCTGGaGATGATCTCTGTGTATTAATCAGCTCACAAATAGTGATTATTTTCAAAAGGTCTTTTGGTAATTTTTTTTTTATCCAGGGCCTTGTGAGAAATCTCATGTTTCTGTTTCCTCATATATTTTCAATTGTTTTTCTTTATTTTCTTCAGTGTCTAATCACTGTATACTATGTAATTCCTAAAGGGAAGGAACCAATCAGAGTTGGTTGAGACTCTATTTTGGTATCGTTAGGACTGGATTGTAGATGAGACTAAATGTCCCAACATAATCTT
>NM_018170.5
ATCTTGCTGGTTTGCGGCCGGTCTTGGATGAAGCGGCGGCCGTGGTGAGAGCGTGGGGAAGGGTGGGGTGAGGGGGCGAGGCCGCAGCTAGGGCGGCGAAACTCTCCTCCCCTCGGCCCCACCGCGTGGGACGGCGTGAACGTGGTGTCGGAGGGATGTCAGCCTTCTCTGAGGCGGCGCTGGAGAAGAAGCTGTCGGAGTTGAGCAACTCGCAGCAGAGCGTGCAGACCTTGTCCCTGTGGCTCATTCACCACCGTAAACACTCGCGTCCCATCGTCACCGTGTGGGAGCGGGAGCTGCGGAAAGCCAAACCAAACAGGAAGCTTACTTTTCTCTACCTAGCCAATGATGTCATACAGAACAGCAAGAGGAAGGGGCCAGAGTTTACAAAAGATTTTGCACCAGTTATAGTGGAGGCTTTTAAGCATGTTTCAAGTGAAACTGATGAAAGTTGTAAGAAGCACCTTGGAAGAGTGTTATCTATTTGGGAAGAAAGGTCTGTTTATGAAAATGATGTATTAGAACAACTTAAACAAGCTCTGTATGGTGATAAGAAGCCTAGGAAGCGAACTTATGAACAGATAAAGGTGGATGAAAATGAAAACTGTTCCTCTCTGGGATCTCCAAGTGAACCACCACAGACTCTAGATCTCGTTAGAGCATTACAAGATCTGGAAAATGCAGCCTCAGGTGATGCAGCAGTTCATCAGAGGATAGCTTCTTTACCTGTTGAAGTCCAAGAAGTATCTCTATTAGATAAAATAACAGATAAAGAATCTGGAGAAAGGCTTTCCAAAATGGTAGAGGATGCGTGTATGTTGCTGGCAGATTACAATGGCAGATTGGCGGCAGAAATAGATGATAGAAAGCAACTCACTCGAATGTTAGCAGATTTTCTTCGTTGTCAAAAGGAAGCCCTTGCAGAGAAAGAGCATAAATTGGAAGAGTACAAGCGCAAGCTAGCCAGAGTTTCCCTGGTGCGCAAAGAACTCAGGTCCCGGATCCAGAGCCTGCCAGACTTATCTCGATTGCCCAATGTCACTGGCAGCCACATGCACCTGCCCTTTGCGGGAGACATCTACAGTGAAGATTGATGGACCAGCCTCTTTCCAGGTCCCAGGACTTTGCAAGAGATGGAGACAGGTTAGGTGGATAGTCCTGTAGTGTTATTTTTGTATATTGTTGAGAAAGAAACACTAACAAAAGGAACAACGAGTAATTTATAAAATTGTTTAAAATGTTGGTTTGTTTACTATTTTATTGGTAAATTAACATGACTTAATTTGAACAAAGTGATGATTTGTGTGTATTAATAAGCTCACAAATAGTGATTATTTTCAAAAGATCTTTTTGTAAATTTTTTTTTTGATCCAAGGCCTTGTGAGAAATCTCTTGTTTGTATTTCTTCAGGTATTTTCAATTGTTTTTCTTTATTTTCTTCAGCATTTAATCACTGTATACTATGTAATTCCTGAAGGGGAAGAACTAATTAGGAGTTGATTGAGACTTTATTATGGTATAGTTAGGACTTGATTGTAGAAGGGACTAAATGTTCCAACATAATCTTTACCCTTCTCCCCAAACAAAATATCAATTCTGTGTCTCTACATGCCTTTGATTCCTTAGAGGTCGGTAATTTAACATAAAACAGGGATGTCACTTTGAGGGGCAGATGAAAGTCTAGAGAACTGTTCCTTAATAGCATTGTAAAAGTTCCATTCCAACTGCCAGTGTAGATTTTAAAAGTGTTAAATAGTGACTCCCTTGATTAAACTGTTTGTAATTATTTGAGTAGATTAATAATGAAAATACTTTGGAAATAATATACATTTTGACATTCTACCAAGAGGACAACTTTGGTTCTGGAACTGGTTTCTATTTGTCAAATCAGTTTCCTTTTAACATAATTAATCCCTTTAACAAAAAGCCGTCTATGGGATTAAAAGACACGTGAAATGATACTTTTATTATTCCCTTGCTCATATAACTTTAAAAATAATACTTTTAGCTCTAATAGCTCAAGAACACAATATTCGTTAATGTTCAGTAAAGTAGCCTGAGACATTTTCAATGTTTCCTTAAGGTTTTTGAATGACTGTATATTTGGCAGTTAAGCAGTGCCACACTACAGGGTAGATATGGTAAATTTTATATTTGTATATTTACAGTTACAAAACAAATGTACTTTTACCTTTTATTTCTGACCCTGTGTGTTAGAGCAGTTGCATGCTCTCCTGCTGTTAAAAACACATTGTTAAGCTGTGGATTTGTACTCAATAATGACTTAGGATAAACATTTATTTTCATTCATTGCTTTACATACTAGACATTTTTCTTCTCTTTGTAAGTAGATTCAAATTAGATAGTCAATAAAACATCTTGAAAATCCCACAAGCCAATTATGTCTCTCTAGTCTGAATGGCTTCATTGTTTCTTTCTCAGTATTAGAAATTATAGTTACAATGAATTGCATATGAAGAAGGCAGACATTTATTTTTAATAGCCAAGTAGTTCTGCAAATAGTTCTTTTAACAATTTGACCTCTCTCCAAAACAGAGACACATATAAGTAGTGCTCATCCATGCACTACTAATAATACATGGCTTATTCCAAAgtttttagtcaacttttgggacttggggtgcattttctcacagaaagaatagtagttaggttccctaacactaCCGCTGATAGCTCACCTGGGAACTGAATCCACCTAACCATGAATGTCCTTCACTTGTAACGTGGTTCACAGGTTACTAATCATAGATCCTGACCAGCATTTGTAACACTGCTCTAACTAGGACACAGCATGCAGCAGCCACACTCACACCCTGGGATGTCTGTGTACCTCTGTCCCTAGGTGTAGGAAATGGAAGAAAAAGATTCAGCCAAGTGGGGAGGTGACAGATGCACAATTATGAAACCTGGTTGTACATGTTATGAAAGTATACTAAGTAAGTTAGTTTTTATTATTAATGTGAAAGCAAAAACTTGTATGTTAACTTATTTTCAATATCTTGACCTTATTTATGATCTGCTAAAGTGGTGATTTATCCATTCAAAATATATATTTTTTTCCATTTAAAACTAATTTATAAACTATGTACTCCTGGGAAGATTTGAAATCTTTTAGAAGTTTGTTGAAATATTTTCACCATTTCAGACAGACTTCTGACTTAGATACTGATTTTAATGCCAGTATCTGCTCTAAATATTTATGATAAAAATGCATTATTTTTTTAAAGAGCTTGATGAGATTTGTGATAAGTGATAGTACTCAAAAACCTGAATCCCACCCCTCGACCAATCCTCCACAAACTTCAGTTGTTGGTTAACGTATTAACTGAACACAGACAATACAGTCTGATTTAGAAGTCATCTTTTCAGCCGTGTGATAATTAACATGGTAAGCCTTAGCAGCAAACATTCTTCCTAAAAGGAAGACTTCATTTTCTCAAGAAATGGGATTAGTTGGGGGTATTATAATACCAAATTGTAAATCATGAGCGTTTTCTCCACTGTGCACCTGAGGCAGATCATGCATCTTTGAGTGCAGTTTGGTCTGACCCCTCAAGAGAAAAGCATGGTGCCGTAGGGCTGCTATGGTTTGAATGGATGCCATCACTCTTTTCTCCACATACAGTGCAGAGAGCTGTCTGGAGTCACAATCTGAACAGATTCTCGGGCGCTCCTTCTCTCCTTCCATCACTACAGTAAGTAAAAGGACCATAGAGGGGAACCAGGAATCTGAGAATCAGCTGTGCTCAATAGCCAACCTCCCTGTCCAGATGCAGCTATTTTGGTATCTCCTATCACATGCACTCTGAATCAGGGTTTTTCTATAAGAAATCTTTCAGAATCAGCAAAAGTGGGGATGACCCAGGCATCTTGATTTGCAAAATCACAAAACTAAGTTGTCAGTTATCACTGTAGATGAGCAACTCATCTTTTTAAAGTATAGTTACTGAACTGATTCTGAGAAATCTTTAGAGAGAAAAAACTCAACAGTACAAATTAACTAATTGGGAAAGTTAGAATGTCCTTTCTGAATTTTTCATTAAAAAAATTACATTATCTGAAATAACATAAAGCTACTAAACTGCTTTGTATTCTATTAAGAAATAGCTCCTAAGGATGTAGTCTTGTTTCATAGTTGTTGCACTATATCAAAACTTAAAATGTAAGCCCAGTTCTTCTCTGTATAGAAAGGAAACATTGTGTTACTTAATGAATTATTTATACAGAGCATTTGTTGCCAACTGTTGTTCCAGCCATCCACACAGGAGTCTGTTCTGAGGTGGCAATAGCACATGGGAAGATGAACTTTCCCTGTTTGTTTACCCGTTCTTCTTTGGCTGTATCTGATGACAGTATAAGATGTTCTTAATAAAGTTTTATGTTCTTTTTGAAATGTG

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