Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBXW12P1
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:5838053-5838657  UCSC
Coordinates (T2T) chr16:5867784-5868388  UCSC
Coordinates (hg19) chr16:5888054-5888658  UCSC
Strand -
Parental Sequence XM_017006224.1
Parental seq. overlap 508 bp
Parental seq. overlap (%) 28.7%
Genomic Region Intragenic (RBFOX1)
Retrocopy Summary FBXW12P1, located on chr16:5838053-5838657, is a retrocopy of the parental gene FBXW12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBXW12
Full Name F-box and WD repeat domain containing 12
Also known as FBW12|FBXO12|FBXO35
Coordinate chr3:48372219-48394830
Strand +
Gene summary Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FBXW12P1
Bonobo Pan paniscus FBXW12P1
Gorilla Gorilla gorilla FBXW12P1
Orangutan Pongo abelii FBXW12P1
Gibbon Nomascus leucogenys FBXW12P1
Crab-eating macaque Macaca fascicularis FBXW12P1
Rhesus Macaca mulatta FBXW12P1
Golden snub-nosed monkey Rhinopithecus roxellana FBXW12P1
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FBXW12P1
GCTGGGCCCCAAAGATGAAAAAACAGGCTAACATGGATGTCCCAAAGTATCATTGGAAGAAAGACAGAATTTATCACCCTTGATCTAACAACCAAAGAGGACGGGCAGCCAAACAGTCATCTAAGCACATGAGATAGCAAGTTTCCCGTTCCCGGCTCATCTGCAGCATCCTAACTGGATGGGAGCCAGAATAGGATATATGATTGTATTTACCAGTGGGCCATTCTTGTTCCTCTCCACCGTCACTGGCTGCAATGATTTAACGACCACCAGACAGCCATCAGCAACTACTGGGTGGCATCCCTCCACATGCTCGCTGCATTCAAGGATAACTCTGTGCAGGTGTACATGTGGAAAGAGGCAGGCCGCCACCCATACCTCAGGAGCTGTTGTCACCTGGAACACACGTGGCAAGATCAGACACCACGCAGCTACATCTCCTACGTAATGTGTGGTAATGTGAGCATAGTACTTAAGGTGAACAAAGTGGATGATTCCAGCATTCTGGTGTTGTATTCTTTCAATATGTAATATGGAAATTAACAAAATTAACCTTGCATCATCTTCTGCCATGTAGTAAAGAGAATTATGTTTTCAAGCCCC
>XM_017006224.1
GCTGTGTGGATCAGGCCCCAGGGGAGAGGCCGGGGTGGAGGTCAGCCCGGGAGTCTGCACACCTGCAGCTTGTTTCTACCGCACACAGATGGGCATGGGTGAAAATCTTTACAAGTGCTGCAGACTTTGGCAAAGCCTATAAATTCAGAGCAGCCCGGAGAGGAGAAAGGAAAGTGGATGTGGGTTCAGGCCGCATGAAATGGAGATCCGATTGCCTGACTTAGCTTTGAAGCGAATCTTCTCTTTCCTGGACCTGTTCGGCTTGCTGCAGGTTTCCCAGGTGAACAAGCATTGGAATAGGATTGCAGACAGTGATTACCTGTGGagGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGACCTTGCATCATCTTCTGCAATGTAGTAAAGAAATTCTATTTGCAAGCCCAGAATGATTATTTTAGTGAAATTTAGATGCTGTGgcctgaagtggtggcacatggctatagtccctgctatttgggaggctgaggtgggaggatcctttga

Publications

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