Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KARS1P3
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:68002438-68003202  UCSC
Coordinates (T2T) chr16:73798226-73798990  UCSC
Coordinates (hg19) chr16:68036341-68037105  UCSC
Strand -
Parental Sequence NM_001130089.2
Parental seq. overlap 679 bp
Parental seq. overlap (%) 31.2%
Genomic Region Intergenic
Retrocopy Summary KARS1P3, located on chr16:68002438-68003202, is a retrocopy of the parental gene KARS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KARS1
Full Name lysyl-tRNA synthetase 1
Also known as CMTRIB|DEAPLE|DFNB89|KARS|KARS2|KRS|LEPID
Coordinate chr16:75627724-75647665
Strand -
Gene summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KARSP3
Bonobo Pan paniscus KARS1P3
Gorilla Gorilla gorilla KARS1P2
Orangutan Pongo abelii KARSP3
Gibbon Nomascus leucogenys KARS1P1
Green monkey Chlorocebus sabaeus KARSP2
Crab-eating macaque Macaca fascicularis KARSP3
Rhesus Macaca mulatta KARSP3
Baboon Papio anubis KARS1P3
Golden snub-nosed monkey Rhinopithecus roxellana KARS1P3
Marmoset Callithrix jacchus KARS1P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KARS1P3
AGAACTCTACCATAAGATGCTAGTGGTTGGTGGCATTGACCAGGTTTATGAAATTGCATTCCAGTTCTGGAATGAAGGAATTGATTTGACGTAAAATCCTGAGTTCAGCACCCCTGAGTTCTACATGGCCTAGACTATCACAATCTCACGGAAATCACGGGGAAGATGGTTCCAGGGATGGTGAAGCATAATACAGGTAGTTACAAGGTCACCTACTACCCAGATGTCCCAGAGGGATAAGCCTGCAATATTGACTTCACCCTACCCTTCCGGAGAATCAGCATGATAGAAGAGCTTGAGAAAGCCCTGGGGGTGAAGCTGCCAGAAAATAACCTATTTGAAACTGAAGCAATTGGCAAAATTCTTGATAATATCTGCGTGCAAATGCTATTGCGTGCCCTCCACCTAGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGGAGTTCCTGGAAGTGATTTGCAACAATTCTACATTCATCTGTGATCACCCCCAGATAATGAGCCCTTTGGCTAAATGGCACTACTCAAAAGGTCTGACCCAGCGCTTTAAGCTATTTGTCATAAAGAAAGCGATAAGCAATGCCTACACTGATCTAAATGATCCTATGCAGCAGTGGCAGCTTTTTGAAGAACAGGCTAAGGCCGCAGGTGATGATGAGGCCCTGTCCGTAGATGAAAACTTTGTTGCCGCCATGGAATACAGGCTGTCCCCCACAACTGCCTGGGGCATGGTTATTGACCGAGTCACCATGTTTCTCACA
>NM_001130089.2
ACTTTTGGGTCGGGCCCTCCGGGAAGATGGCGGCCGTGCAGGCGGCCGAGGTGAAAGTGGATGGCAGCGAGCCGAAACTGAGCAAGAAGTGGTGGTAATCATTAGTTCCAGGGTGCTCTGCCATGTTGACGCAAGCTGCTGTAAGGCTTGTTAGGGGGTCCCTGCGCAAAACCTCCTGGGCAGAGTGGGGTCACAGGGAACTGCGACTGGGTCAACTTGCTCCTTTCACAGCGCCTCACAAGGACAAGTCATTTTCTGATCAAAGAAGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAGCTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACTACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGACTTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAGCTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAGAAGAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGAGCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGTATCGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTTTCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCACAACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATGAAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTATCACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATGGCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAGCTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCACCTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAGATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCAATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATGTTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGTTTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACACTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGATCAAGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAATTTCTTTTTAATCCTGTTACCAAATAA

Publications

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