Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYCBPP2
Plot displaying the genomic locations of a retrocopy (in chr16) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr16:72278240-72280766  UCSC
Coordinates (T2T) chr16:78094556-78097082  UCSC
Coordinates (hg19) chr16:72312139-72314665  UCSC
Strand +
Parental Sequence NM_012333.5
Parental seq. overlap 1794 bp
Parental seq. overlap (%) 70.3%
Genomic Region Intergenic
Retrocopy Summary MYCBPP2, located on chr16:72278240-72280766, is a retrocopy of the parental gene MYCBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYCBP
Full Name MYC binding protein
Also known as AMY-1
Coordinate chr1:38862493-38873348
Strand -
Gene summary The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MYCBPP2
Bonobo Pan paniscus MYCBPP2
Gorilla Gorilla gorilla MYCBPP2
Orangutan Pongo abelii MYCBPP1
Gibbon Nomascus leucogenys MYCBPP1
Green monkey Chlorocebus sabaeus MYCBPP2
Crab-eating macaque Macaca fascicularis MYCBPP2
Rhesus Macaca mulatta MYCBPP2
Baboon Papio anubis MYCBPP2
Golden snub-nosed monkey Rhinopithecus roxellana MYCBPP3
Marmoset Callithrix jacchus MYCBPP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MYCBPP2
GCTACGCTGCTGTCGCTGTCACTATGGCCCATTACAAAGCCGCCAACTTGAAGCGTGAGCAGTTCCGGAGGTACTTGGAGAAGTCAGGGGTGCTGGACACACTGACCAAGGTGTTGGTATGAAGAACCAGAGAAACCTAACAGTGCTTTGGATTTCTTAAAGCATCACTTAGGAACTGCTACCCCAGAAAATCCAGAAATAGAGCTGCTGTGCCTAGAACTGGCGAAAACGAAAGAGAAATATAAAGCTATTGTAGAAAAAAATAAAAAACTGAAAGCAAAGCTTGCTCAGTATGAACCACCTCAGGAGGAGAAGTATGCTGAATAGGATTCTTCTCAGTTGAAAAGACACTGAAAAATGGTTTTGTATCACTTGAATACTTTGTATAATATATAATCTTTTCCAAACAGATGCTATAGAACTCTTTTAATATGTTTAATTCACCTACCACACTCTGTTATAAACACATAGAATCATCAATAAAAACTCAATATAACTTTCTTTGGATTTTAAAGCAGGAGAATCCAAAGTAAATCCTGAAAACACCCTAAACATAGCCATCTAACTCCTTACCTTAAAAGCCATTCTGTTCATTAGTCTGATTAGGAATGATGGCACTGGTTGTGTTTTAGCCAAGGCAGTTTAGCATGGAGCTATTCCTTGGTGTAGTTCAGGATATGAACATAGGTACAGTCATTCTTTGAAGGTGATATACTGTTGTGTACATTCCCTATAGGCAGCTGGAGAGATCTGTGTGACACAAGATGCTTTTGTACAGGTTCCCATGAATCTTCTGCTCTTGTTTGTGTAACATGGAACAAATAACTCTTCTTTGCCACCACTTTGCCTTAGATAATTGTGTGTGTGTGCCAGTTTGAACTCTGATACCACATTTTCCTTCTGTGCAATCATGCCTTGTTTGATAATCTTGCATTGCTTTGCTCTGAGCTTTAGTGGGTCCTACTTACACACTGACTTTTCTATGCTGTTTTTCAATTTGCCTAATAACAGCAGTTACCCTGATTGTAATTTATGCAACTTTAAACAGGATCACACTGTACCCCCTGCCTGCCTTATTTGCTTATTGAGCACAGAACAGAGGCAATATACAACTCTGAGTTCACACACAAGCTGGGATAAGAAGAGGAATGAGCCATATATTGTGGAAAATCATAGTTTGTAGGGAGGGGAAGTTGGGTGCTGAATTTTTAGGCCAAAGACTGATGTTAATACAAATTTCTTGTTTGTGAGTCCTTTTTCCTTTCTTTGGGTAGACTTACAGTCGGATGTTTTGTTTTATTAATCACTTATTTTCCTTATTGATAGACCATCATTTTATAGACATATTCCTATTGCATGTATCCTCTCCCTGTTGTTAGAGAACGTATCTTTGTTTTTGGTCAAAACACACATATAAAACAAAATGATCCAATGAAAACTGGTTTAACTAGCAAAAGCCTTTGCACCTGTTGGAAACTATGACCAAGTCAATTACAAGGGCATTTAAATCAGTCGTGTTAGTAGGAATGTGGCAATGACTGGTGCCTCTTCTAGTCACAAGTTTGCTTTTGGAGGGGGGCCAGATAATATTGGAAGAATATTCGCTTGAATAGATTTCTCTTTTACCAATTTGAGTGCCTCCTACATGGGCAGCAGTGGACTAAGTGCTGGGTGTGATAAAGAGGAATGACTTAATTATGAGACATGTATATAATCAAATACAGTATGGGTTAGGACCTGTGACAAACCATTATAATAAAACATGGCCCCATGAGGGTTTTGAAAGAGAGACAGATTTGGCTTCTTTAGTTGGTAAGATAGTTTCTTGGTAGATACAGGTCGAAATTTTTCTTTCTGTGGCAGCCAATTCTCATGTGCTTTTTACTTATTGGATATACACAAGAAGATGCTTGATGGAAGAGAAAATGGATCTCA
>NM_012333.5
AGTCGCGGTCTCCGGCGCCAGCTACGCCGCTGCCGCTGTCACTATGGCCCATTACAAAGCCGCCGACTCGAAGCGTGAGCAGTTCCGGAGGTACTTGGAGAAGTCGGGGGTGCTGGACACGCTGACCAAGGTGTTGGTAGCCTTATATGAAGAACCAGAGAAACCTAACAGTGCTTTGGATTTTTTAAAGCATCACTTAGGAGCTGCTACTCCAGAAAATCCAGAAATAGAGCTGCTTCGCCTAGAACTGGCCGAAATGAAAGAGAAGTATGAAGCTATTGTAGAAGAAAATAAAAAACTGAAAGCAAAGCTTGCTCAGTATGAACCACCTCAGGAGGAGAAGCGTGCTGAATAGGATTCTTCTCAGTTTGAAAGACAATGAAAAATGGTTTTGTATGACTTGAATAGTTTGTATAGTATATAATCTTTTCTGAACAGATGCTATAGAACTCTTTTAATATGTTTAATTCACCTATCACACTCTGTTAAAAACACATAGAATCATCAATAAAAACTCAATATAACTTTCTTTGGGTCTTAAAGCAGGAGAATCCAAAGTAAATCCTGAACAAAACCTAAACACAGCCATCTAACTCATTACCTTAAAAGACATTCTGTTTATTAGTCTGATTAGGAATGATGGCACTGGTTGTATTTTAGCCAAGACAGTTTAGCATGGAGCTATTCCTTGGTGCAGTTCAGGATATGAACACAGGTACAGTCATTCTTTGAAGGTGACACTGTTCTGTATATTCCCTATAGGCAGCTGGAGAGATCTGTGTGACACAAGATGCTTTTGTACGGGTTCCCATGAATCTTCTGCTCTTGTTTGTGTGACATGGAACAAATAACTTCTTTGCCACCACTTTGCCTTAGATAACTGTGTGTGTGTGTGCCAGTTTGAACTCTGACACCACATTTTCCTTCTATGCAATCATGCCTGTCTGATAATCTTGCATTGCTTTCCTCTGAGCTTTAGTGGGTCCTAGTTGCACACTGGCCTTTCTGTGCTGTTTTTCAATTTGCCTAATAATAGCAGTTACCCTGATTGTAATTTATGTAACTTTAAACAGGATCACACTGTACCCCCTGCCTGCCTTATTTGCTTACTGAGCACAGGACAGAGGCAATATACAACTCTGGGTTCACACACAAGCTGAGATGAGAAGAGGAATGAGCCATATATTGGGGAAAATCATAGTTTGTAGGtataattatatagtgcttttctccctcaaagtatttttctagccttgaattcattttatcttcattatccctgtgaagtaggtgggacaagtatAAGGGGAAGAGGGGTGCTGAATTTTTAGGCCAAAGACTGATATTAATACAAATcactcactaactgtagagccttgggcattatcagtgaactactctgagatttactgtcttcatctgtttaatgagtagaatgtccgtgatgcctacctcacagggttgttgtgagggtcaaatgagaatgtatgtgaaagatttgtaaatggtaaagcactataTTCTTGTTTGTTAGTCCTTTTTCCTTTCTTTGGGTAGACCTACAGTCAGATGTTTTGTTTTATGGATCACTTATTTTCCTTACTGGTAGACTGTCGTTTTATAGACATATTCCTATTTCATATATTCTCTCCCTGTTGTTAGAGAACCTATCTTTGTTTTTGGTCAAAACACACATAGAAAACAAAATGATCCAATGAAAACTGGTTTAACTAGCAAAAGCCTTGGCACCTGTTGGAGACTATGACCAAGCCAATAAAAAGGGCATTTAAATCAGCCCTGTTAGTAGGAATGTGGCTATGGCTGGTGCCTCTTCTAGTCACAAGTTTGTTTTTGGAGGGGGTCCAGAAGATCATTCCCTTGCATAGATTTCTCTTTTACCAATTTGAGTGCCTCCTACATGGGCAGCAGTGGACTAAGTGCTGGGTGTGATAAAGAGGAATGACTTAATTATGAGACTGTATATAATCAAATACAGTGTGGGTTAGGACCTGTGGCAGACCATTATAATAAAGCATGGCCCCGTGAGGGTTTTGAAAGAGAGAGAGACTTGGCTTCCTTAGTTGGTATGATAGTTTCTTGGTAGATACAGGTTGAAAATTTTTTGTGGCAGCCAATCCTCATGGGCTTTTTACTCATTTGATTAGTATTAatatttatgtcagtaagccaggtgactgtgactgtctttggtaccatcctttttgaacagaaaggcaacatgtgggttggataatCACACTTTTAGGTGAAACTGACTTGCTTAAACTGTAACAGTCAGTGCTATTTAAGAATTCAGGATAAGCTTAGCCTCTAGAGgtcctcttcaacatttctgtcaaggatttggatgaatacaacaagatgctCCATGGAAGAGAAAATGGATAAATGGATCCCACCAGttaagctcctattatgcttcagctgctttgtctataaaatatcgacttcacatcttgcctatctcacaagttggttgtaagaatcaaattaaatataatggatgtaaaa

Publications

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