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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PIN1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:69919346-69919869  UCSC
Coordinates (T2T) chr1:69797508-69798031  UCSC
Coordinates (hg19) chr1:70385029-70385552  UCSC
Strand +
Parental Sequence NM_006221.4
Parental seq. overlap 485 bp
Parental seq. overlap (%) 48.1%
Genomic Region Intragenic (LRRC7)
Retrocopy Summary PIN1P1, located on chr1:69919346-69919869, is a retrocopy of the parental gene PIN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PIN1
Full Name peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Also known as DOD|UBL5
Coordinate chr19:9835318-9849689
Strand +
Gene summary Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PIN1P1
Bonobo Pan paniscus PIN1P1
Gorilla Gorilla gorilla PIN1P1
Orangutan Pongo abelii PIN1P1
Gibbon Nomascus leucogenys PIN1P1
Green monkey Chlorocebus sabaeus PIN1P1
Rhesus Macaca mulatta PIN1P1
Baboon Papio anubis PIN1P1
Golden snub-nosed monkey Rhinopithecus roxellana PIN1P1
Marmoset Callithrix jacchus PIN1P2
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PIN1P1
GAGGAGGAAAGATGGCGGACGAGGAGAAACTGCCGCCTGGCTGGGAAAAGCGCATGAGCCGCCCCTCAGGCCGAGGGTACTACTTCAACCACATCACTAACCCCAGCCAGTGGGAGCGGCCCAGCGGGAACAGCAGCAGTGGCGGCAAAATCTGGCAGGGGGAGCCCGCCAGGGTCCGCCGCTCGCACCTGCTAGTGAAGCCAGTCAAGGCGGCCCTCGACCTGGCGGCAGGAAATCACCCGGACCAAGGAGGAGGCCCTGGAGCTGATCAGCGGCTACATCCAGAAGATCAAGGCAGGAGAGAAGGACTTTGAGTCTCCGGCCTCACAATTCAGCGACTGCAGCTCGGCCAAGGCCAGGGGAGACCTGGGTGCCTTCAGCAAAGGTCAGATGCAGAAGCCATTTGAAGACCCCTGGTTTGCGCGGCGGACGGGGGAGATGAGCGGGACAGTGTTCACGGATTCCGGCATCCACGTCATTGTCCGCACGGAGTGAGGATTGGGGGCCCAGGCCTGGCCTCGGGG
>NM_006221.4
ggagcaggcgctgcggcAGGAGGGAAGATGGCGGACGAGGAGAAGCTGCCGCCCGGCTGGGAGAAGCGCATGAGCCGCAGCTCAGGCCGAGTGTACTACTTCAACCACATCACTAACGCCAGCCAGTGGGAGCGGCCCAGCGGCAACAGCAGCAGTGGTGGCAAAAACGGGCAGGGGGAGCCTGCCAGGGTCCGCTGCTCGCACCTGCTGGTGAAGCACAGCCAGTCACGGCGGCCCTCGTCCTGGCGGCAGGAGAAGATCACCCGGACCAAGGAGGAGGCCCTGGAGCTGATCAACGGCTACATCCAGAAGATCAAGTCGGGAGAGGAGGACTTTGAGTCTCTGGCCTCACAGTTCAGCGACTGCAGCTCAGCCAAGGCCAGGGGAGACCTGGGTGCCTTCAGCAGAGGTCAGATGCAGAAGCCATTTGAAGACGCCTCGTTTGCGCTGCGGACGGGGGAGATGAGCGGGCCCGTGTTCACGGATTCCGGCATCCACATCATCCTCCGCACTGAGTGAGGGTGGGGAGCCCAGGCCTGGCCTCGGGGCAGGGCAGGGCGGCTAGGCCGGCCAGCTCCCCCTTGCCCGCCAGCCAGTGGCCGAACCCCCCACTCCCTGCCACCGTCACACAGTATTTATTGTTCCCACAATGGCTGGGAGGGGGCCCTTCCAGATTGGGGGCCCTGGGGTCCCCACTCCCTGTCCATCCCCAGTTGGGGCTGCGACCGCCAGATTCTCCCTTAAGGAATTGACTTCAGCAGGGGTGGGAGGCTCCCAGACCCAGGGCAGTGTGGTGGGAGGGGTGTTCCAAAGAGAAGGCCTGGTCAGCAGAGCCGCCCCGTGTCCCCCCAGGTGCTGGAGGCAGACTCGAGGGCCGAATTGTTTCTAGTTAGGCCACGCTCCTCTGTTCAGTCGCAAAGGTGAACACTCATGCGGCCCAGCCATGGGCCCTCTGAGCAACTGTGCAGCACCCTTTCACCCCCAATTAAACCCAGAACCACTGCTCTGC

Publications

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