Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TMEM14CP1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:1601263-1601403  UCSC
Coordinates (T2T) chr17:1490032-1490172  UCSC
Coordinates (hg19) chr17:1504557-1504697  UCSC
Strand -
Parental Sequence NM_016462.4_2
Parental seq. overlap 121 bp
Parental seq. overlap (%) 11.9%
Genomic Region Intragenic (SLC43A2)
Retrocopy Summary TMEM14CP1, located on chr17:1601263-1601403, is a retrocopy of the parental gene TMEM14C. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TMEM14C
Full Name transmembrane protein 14C
Also known as C6orf53|HSPC194|MSTP073|NET26|bA421M1.6
Coordinate chr6:10723070-10731127
Strand +
Gene summary Predicted to be involved in mitochondrial transport. Predicted to act upstream of or within erythrocyte differentiation and regulation of heme biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TMEM14CP1
Bonobo Pan paniscus TMEM14CP1
Gorilla Gorilla gorilla LOC101134115P1
Orangutan Pongo abelii TMEM14CP1
Gibbon Nomascus leucogenys TMEM14CP2
Green monkey Chlorocebus sabaeus TMEM14CP3
Crab-eating macaque Macaca fascicularis TMEM14CP3
Rhesus Macaca mulatta TMEM14CP3
Baboon Papio anubis TMEM14CP2
Golden snub-nosed monkey Rhinopithecus roxellana TMEM14CP3
Marmoset Callithrix jacchus TMEM14CP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TMEM14CP1
TAGCAGGCCTGAGTGCTTATTAGCCATCTCGGGATCCAGGGAACATTTGGGTTTTCCCAGCTACACCTGGAAACTTGGCGGGCATATGGGAATGAGATTCTACCACTCTGGAAGATTCATGCCCACAGGTTTCATTGCAGT
>NM_016462.4_2
ATTCTCTGACCGCCCCTCTCCCGGTACACTGCGCAGGCACAACAGAGCCGCTCCCCTCTCCTCGCCCCGCCACCGGGACGGAGAGCGCCCGCCGCTGCATTTCCGGCGACACCTCGCAGTCATTCCTGCGGCTTGCGCGCCCTTGTAGACAGCCGGGGCCTTCGTGAGACCGGTGCAGGCCTGGGGTAGTCTCCTGTCTGGACAGAGAAGAGAAAAATGCAGGACACTGGCTCAGTAGTGCCTTTGCATTGGTTTGGCTTTGGCTACGCAGCACTGGTTGCTTCTGGTGGGATCATTGGCTATGTAAAAGCAGGCAGCGTGCCGTCCCTGGCTGCAGGGCTGCTCTTTGGCAGTCTAGCCGGCCTGGGTGCTTACCAGCTGTCTCAGGATCCAAGGAACGTTTGGGTTTTCCTAGCTACATCTGGTACCTTGGCTGGCATTATGGGAATGAGGTTCTACCACTCTGGAAAATTCATGCCTGCAGGTTTAATTGCAGGTGCCAGTTTGCTGATGGTCGCCAAAGTTGGAGTTAGTATGTTCAACAGACCCCATTAGCAGAAGTCATGTTCCAGCTTAGACTGATGAAGAATTAAAAATCTGCATCTTCCACTATTTTCAATATATTAAGAGAAATAAGTGCAGCATTTTTGCATCTGACATTTTACCTAAAAAAAAAGACACCAAACTTGGCAGAGAGGTGGAAAATCAGTCATGATTACAAACCTACAGAGGTGGCGAGTATGTAACACAAGAGCTTAATAAGACCCTCATAGAGCTTGATTCTTGTATATTGATGTTGTCTTTTCTTTCTGTATCTGTAGGTAAATCTCAAGGGTAAAATGTTAGGTGTCAGCTTTCAGGGCTCTGAAACCCCATTCCCTGCTCTGAGGAACAGTGTGAAAAAAAGTCTTTTAGGAGATTTACAATATCTGTTCTTTTGCTCATCTTAGACCACAGACTGACTTTGAAATTATGTTAAGTGAAATATCAATGAAAATAAAGTTTACTATAAATAA

Publications

PMID - Link Title