Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name OLA1P2
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Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:20776425-20776900  UCSC
Coordinates (T2T) chr17:20725239-20725714  UCSC
Coordinates (hg19) chr17:20679738-20680213  UCSC
Strand +
Parental Sequence NM_001011708.3
Parental seq. overlap 435 bp
Parental seq. overlap (%) 10.5%
Genomic Region Intergenic
Retrocopy Summary OLA1P2, located on chr17:20776425-20776900, is a retrocopy of the parental gene OLA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name OLA1
Full Name Obg like ATPase 1
Also known as DOC45|GBP45|GTBP9|GTPBP9|PTD004
Coordinate chr2:174072447-174248532
Strand -
Gene summary This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes OLA1P2
Gorilla Gorilla gorilla OLA1P1
Orangutan Pongo abelii OLA1P2
Gibbon Nomascus leucogenys OLA1P2
Green monkey Chlorocebus sabaeus OLA1P2
Crab-eating macaque Macaca fascicularis OLA1P1
Rhesus Macaca mulatta OLA1P1
Baboon Papio anubis OLA1P1
Golden snub-nosed monkey Rhinopithecus roxellana OLA1P3
Marmoset Callithrix jacchus OLA1P2
Bonobo Pan paniscus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.4
log10(TPM+1)

Related Sequence

>OLA1P2
aAACAAATGGTTGATAAAAATAAAAATAAATTAAATAGTGGGTGGACAAGTATGACCTAGGTGCCTTTGTCGTTCCTTTTAGTGGGGCCTTGGCAAGAATTGAGTGCTGAGGAGAGACCGGAGTAACTGGAAGCAAACACGACTCAAAGTGCTTTGCCAAAGATCATTAAGGCTGGGTCTGCAGCACTCCAACTAGAATACGTTTTCACTGCAGGCCCAGATGAAGTGTGTGCAGGGACCATCAGGAAAGGGACTAAGAATCCTCAGGCTGCAGGAAAGATTCACACAAATTTTGAAAAGAGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAATGGGAAGGTTCTGAAATGCAGTCAAGGCTGCCGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAACACACCTCAACAACCGAAGAAGAAA
>NM_001011708.3
CTTCCTCCCCGCCTCCAGCTGCCGGCAGGACCTTTCTCTCGCTGCCGCTGGGACCCCGTGTCATCGCCCAGGCCGAGCACGGAAATCTACTTTCTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTCCCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGATGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGCAAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAAAGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCTCATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGTGCTTTTGAAGATGATGATATCACGCACGTTGAAGGAAGTGTAGATCCTATTCGAGATATAGAAATAATACATGAAGAGCTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAGGTGGCTGTGAGAGGAGGAGATAAAAAACTAAAACCTGAATATGATATAATGTGCAAAGTAAAATCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGATTGGAATGACAAAGAGATTGAAGTGTTGAATAAACACTTATTTTTGACTTCAAAACCAATGGTCTACTTGGTTAATCTTTCTGAAAAAGACTACATTAGAAAGAAAAACAAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCTTTGGTCATTCCTTTTAGTGGGGCCTTGGAACTCAAGTTGCAAGAATTGAGTGCTGAGGAGAGACAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATCATTAAGGCTGGGTTTGCAGCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACTAAGGCTCCTCAGGCTGCAGGAAAGATTCACACAGATTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAGGAAGGTTCTGAAAATGCAGTCAAGGCTGCTGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAACACACCTCAACAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTGAAAACCAATGCGACAAATAAAGTTGGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACCCCCCCCCCCCCATGAAATGCAGGTTCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTCAGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCTCCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAAAACCAGCCTTGGTGTGTTTGGGGATGTCTGTATTGACTGACTGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAATTTTAAGGCGTGTGTATGACACAGTAACTGGCAGTGTGGGGCAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAATAGTATACCAGGGATTTGTCTCAAAAAAGTTAATTAATTTATAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATATGAGATAGGTGACTGACCACAAAGAAGAAAATTCTGTCTCAAAAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGAGGTTCACTTTTAATCTTTCCTTTGAAATTATTAAATTGTAAAAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCAATGTGTATAAAAGTTCCTACACTGATTTTGAAATACTAAGATCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATATTTGAGAGCAGTCGAAGTGGTAGTATGGGTAAGTTAAGCACTTCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGGTAATTTGGAGACCCTTTGCCACTTAGCCTTCTCTTGTGATGATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTTTCCATTCCTGTGAGACCTCCCTTCCTTGTCCTTGTCCTCTGCCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGATTCATACCCAGCCAGCCTTTGCCTCTACTGTATCGCTTTGGGACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAAAGTTACCAAATGTAGCACTAGAGGCAAGAAAAGGGGTGATTTTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAGTCGTGAGTATAATTTAGAAGCTCTCCAGTGAGTATTTTTTTAGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTACAGCAGAGAAATAAGAATAAAACTAATGAAGGGTTTTTTAAAAGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAGTTTGCTGTGAAAAATCCTTGTTATATCTATTTCTGTATTGGAGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAAGAATCAAATATCTTGCTTTTGGGTCTTCTCCAAAGTAAATTGCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATCATGCAATTTTACTTTGTCTAGCTTCTAATGTGGTAAATTGCACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGTAACTGCATTCATTAGGGGCTGAAAATAAATGTTAAAAATGTTTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTTCATTTTCTCTGAAAGTCGAGAATTCCAAGAACTGTTACATATAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGATAAAGTTAATATATTTTAGGATGTTATGTAAATATTTTTGCATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTGAggccaggcgtggaggctcacacctataatcccaacactttgggaggccgaggtgggaggatcacttgagcacaggagtttgagaccagcctgtgcaacatcatgaaacatcatctctacataaaaaaatacatatatacaaaaattagctgggcatcatggcacacacctgtagtcccagctacttaggaggctgagatgggaggattgatcgatcgcttgagcctgggaggtggaggctactgtgagccatgatcatgccactgcactccagcctgggcaacagagtgagaccctgtctccaaagagaaagagaaaCTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAATAGCATTTAGTTGTGTTTTATCATGTTATCTTCATAACATGCATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAATAGTTTTTGTCGCTAACTTAGTTATGAGTGAAGCCTCTGTTCACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATGATTCATCAATATTCCTATATTAAAATTCCAGTTTGATGTTTGTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCCGTCTCCTTTCATTCAGAGAGTCAGAGACGGTATCTCCTCCTCCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCTCTTTTTATTTTACAAGAGACTTGAGAAATGTCGGTTGTTCCTAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAGCTTGTAAAATACACTGTGGTGATAAAATAAAAGAGCTGGGTTTGA

Publications

PMID - Link Title
26898989The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation.