Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RNASEH1P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:20901975-20902777  UCSC
Coordinates (T2T) chr17:20850791-20851593  UCSC
Coordinates (hg19) chr17:20805288-20806090  UCSC
Strand -
Parental Sequence NM_001378271.1
Parental seq. overlap 773 bp
Parental seq. overlap (%) 14.6%
Genomic Region Intergenic
Retrocopy Summary RNASEH1P1, located on chr17:20901975-20902777, is a retrocopy of the parental gene RNASEH1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RNASEH1
Full Name ribonuclease H1
Also known as H1RNA|PEOB2|RNH1
Coordinate chr2:3541430-3558333
Strand -
Gene summary This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RNASEH1P2
Bonobo Pan paniscus RNASEH1P2
Gorilla Gorilla gorilla RNASEH1P3
Gibbon Nomascus leucogenys RNASEH1P2
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RNASEH1P1
GGGAGTCGAAATGCTTCCTGGTGCCGGGAGTGAGCGATGAGCCGGCTTCTGTTCCTGGCCGCAGAGTCGCCTTGGCCGCCTTGCCCTGCCGCTGCTCTCACGGGTTCGGGATGTTCTATGCCGTGAGGAGGGGCGGCAAGACCGGGGTCTTTCTGACCGGGAATGAGTGCAAAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAGTTTGCCACAGAGGATGAGACCTGGGACTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCAGAAGGGCAGGAAAATCAACATGGACAAGAATCAGAGACGAAAGCCAGCAAGCGACTCCGTGAGCCACTGGATGGAGATGGAGATGAAAGCGCAGAGCCATATGCAAGCACATGAAGCCGAGGGTGAAGCCGGCGCCTCCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTCGTCGTCTACGCTGATGGCTGCTGCTCCAGTAATGGGCGTAGAAGGCCACGAGCAGGAATCCGCGTTTACTGGGGGCCGGGCTATCCTTTAAATGTAGGCATTAGACTTCCTGGGTGGCAGACAAACCAAAGAGCGGAAATTCATGCAGCCTACAAGGCCATTGAACAAGCAAAGACTCAAAACATCAATAAACTGGTTCTGTATACAGACAGTATGTTTACGATAAATGGTGTAACTGGGTTCAAGGTTGGAAGAAAAATGGATGGAAGACAAGTGCAGGGAAAGAGGTGATCAACAAAGAGGACTTCGTGGCACTGGAGAGGCTGACCCAGGGGATGGACATTCAGTGGGC
>NM_001378271.1
GGTGTTGAGCGCCGGCGGCTCGCGCCCACGCTGGGCCGGGAGTCGAAATGCTTCCCGGTGCCGGGAGTGAGCGATGAGCTGGCTTCTGTTCCTGGCCCACAGAGTCGCCTTGGCCGCCTTGCCCTGCCGCCGCGGCTCTCGCGGGTTCGGGATGTTCTATGCCGTGAGGAGGGGCCGCAAGACCGGGGTCTTTCTGACCTGGAATGAGTGCAGAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAGTTTGCCACAGAGGATGAGGCCTGGGCCTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCAGAAGGGCATGAAAATCAACATGGACAAGAATCGGAGGCGAAAGCCAGCAAGCGACTCCGTGAGCCACTGGATGGAGATGGACATGAAAGCGCAGAGCCGTATGCAAAGCACATGAAGCCGAGCGTGGAGCCGGCGCCTCCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTCGTCGTCTACACTGATGGCTGCTGCTCCAGTAATGGGCGTAGAAGGCCGCGAGCAGGAATCGGCGTTTACTGGGGGCCAGGCCATCCTTTAAATGTAGGCATTAGACTTCCTGGGCGGCAGACAAACCAAAGAGCGGAAATTCATGCAGCCTGCAAAGCCATTGAACAAGCAAAGACTCAAAACATCAATAAACTGGTTCTGTATACAGACAGTATGTTTACGATAAATGGTATAACTAACTGGGTTCAAGGTTGGAAGAAAAATGGGTGGAAGACAAGTGCAGGGAAAGAGGTGATCAACAAAGAGGACTTTGTGGCACTGGAGAGGCTTACCCAGGGGATGGACATTCAGTGGGAAAACATTTATCTTAACAGATGCATGTTCCTGGTCATTCGGGATTTATAGGCAATGAAGAAGCTGACAGATTAGCCAGAGAAGGAGCTAAACAATCGGAAGACTGAGCCATGTGACTTTAGTCCTTGGGAGAACTTGAGCCAGCGGCTGTCTTGCTGCCTGTACTTACTGGTGTGGAAAATAGCCTGCAGGTAGGACCATTGCAGTGATGGGCAGATGCGTCTTTCACACGGAATCAGGCACAGTGGCCTTCTGTGACATGTGTTTATAAAAAATGGTTAAGTATATAATAAATTGAACATCTTTGAGATTGGAGAATTATGTGAGATTTCCACATTATGTTTACTGGGTTCAATACTGTCCTTGCTTGTTTTATTGCAGGCAAGCAAGGCAAATGGCCTAAAATGCTGTGGCTTATATTTTGATAAGAAATCAAAAAACCATTGGTTAAAAGATGCAACTCAGAAGTCTGGAAGTATTCTGAAAGCATCCATTTACCGTCCAGTTGACAGGTTTGAGTCTCCTGCTTGTATAGGTGACTTGTGCCCATGGGTACATTAAAGGAACATGCTGCCCAGGGCCTGGGCGGACAGCTCAGTGGGCAGGATGTGTGCTGGGTCTCAGCCCCATGTGCCTGCTTGCTGGGCAGTTAGTATAGGGCAAAGCCTGCCTGCGGCGACCCTGGCTGCTAGGCCATTCTCTAGGAACAGCTGCGACTCATAAAGACCAAGAAGCATAAATAAACTTTCAAAAATTTATTTGGCTCTTTCGTTAAAAACTGTGCAAATTaaaaaaaaaaaaaaaaaaGTAAGACACCggctgggcacagtggctcacttctgtaatcctagcactttgggaggccaaggcgggcagatcacttgaggtcaggagtttgagaccagcttggccaacatgacgaaaccctgtctctactaaaattacaaaaattatccaggtgtggtggcacgggcttgtagtcccagctacttgggaggctgaggcacaagaatcacttgaacccaggcggcagaggttgcagtgagccaagattgcaccactgcactccatcctgggcaacagagtgagactctgtctcaaaaaaaaaaaaaaGTAGTAAAAGTTTGACATGATTATTTATTTAGttttaaacctttttattataaaaacatacaggaagtgacacaaaacaaatgtatagcttattgaatgattatgattgtaaggtgaataacctttgtgtccaccacctggtgaagaaatagtactttgccagataccccaggaggctctcccaagtgcccctccagccacagccctcttcttctccccctccttgccccaacaagtaatcctgacttttacagaaatgactttcttggttttttGATGGCAGTTTAGTCTTGTCTGCTTTTTTTTGTTTATTTTTTTATCTACTTCAGTGTCCATTTGCAGTCCCGTCGGCCTCACTGttttccctgccgtttatctgttgaagagcctgggctgtttgtcccatggcttcccacagtgtagattttgctgaccacgtggtcatggtgtagttcagcatggtcctctatgtttcctgcacattggcagctgggtccagaggcttgatgagcctcaaatttgatccctttggcaggagaacaggcggttaggagctttcctcaggaaagtaccatgttgacggcagctgatgctcagtgccaagatccattaattatttggggttgcaaaatggtggtattctcattctgtcgttttgcttgcctttattagctggaatggttttctaagaaagtgttttcttttttatacttatctggttacccagtggtacagttcatataggaagggcaggataaatgcttgattctttgctcttgtacactaagtttttaagataatgcattagttgtctgtcaaggaaggtgagtggtgaagggtttttacatatatacaagaattcatgggctgggcatggtgtcttatgcctgtaatcccagcactttgggaggctgaggctggaggatcacatgaacccaggagtttgagactagtctgggcaacatagtgacaccctgtctctacagaaaattaaaataaaatcaggtgggtgtggtagtgcctgcctgttgtcccagctattctggaggctgagatgggaggatcgcttgggcccaggaggtcgaggatgcgtgagctgtgaccatgccaccacattccagcctgggcgacagcaagtccttgtcttaaaaaaaaaaaagaatttgtggagttaagcatacttggtgggtttcaatccgttgtgatttttatctttatttagctcagactagcttattcggtcagtgagagggagcctcttcagcttggctcttgctttcttttgataagtgtgcacatgtgtgcatacatgtgtgcacagaccacacgcacagtcattgatagctccctgcagcctggcatgtcaagatgctctaggcccaatttatagagcttctgctccaaacctgTCttaaaagaaaaactttagacaagttagcagtttaattgagcagaaaatagtttcttcagctgggtagcactcaggaccaaaagtggttcagaacgttctcctgtgcgttgtgtgcaggctgtatttatttatagccacaggaagggaaagacacatgtacatggccagactgactgcaggtcagcctccacctcacataggcatgttttgggagccttcagcatgtgattggtgagactctgctgcttgttacagaagtgtactctcaagtcaggtcccagtttgcttatacattaagtgaggttataagtcactatgtacagaggcagttttaggccaaacttaattCCGTTTAACacttggaatccattatttttcccagagtctctggtagagatggtatttcagatccagtttaggatgctcattgctattgcgttggtcattatttctagatttttggacggagctttaaaaaaatacaaacattgcacacacatatttaaaggaagaatattttctgagcctatattgatattcccaatacaaattcagggtcctggggcctttacatagcctcctctatatgatgtctgtgtctcctgcactcggaatcctgcttctcaagacacaggacaatggcatggaatatccatcccttaatcactcacttgttttattcctctttagcatttagcatttaaaaaaaatactaataccatagcattaattgtgatgatgaaaacagCACTGTGTCTACGTTGTCAGAAAAATTGCTCCTTTTTACCACCATTGACTCATTTCTGTGTGTTCAGGTCTCATAACCAGTCTATAGTCAGTGTCAtcttggggacagtattccttgagtttctgatgttgaattcagttttgctggatacgaaattcttggcccagattttctttgagtatcttgttttattctgttttcttccagcataaagtgatgcatgaaaagcctgatgaatcttgttttcttcccctgacagtcatatgctgtttttccttagatgcccaaaggattttttcctttttctgtcaagtcggccgttttattcgaatgtgtcatgtgttggtattggttgtcctggtccatatttgcaagcgtatggtgtgctctttctatgtgtacttcatatctgttattttaagaagatttgcttgaactggagtttagtgttacatttttcttgctttggcttttttctgtggggatccctgttatctgtatgttgaaatctaaattggctgttctcagtgtttgccactgtctcttgaatctcttttatctctttctttgtttctttttgagttttaaaagttGTTATTGTACCACTTTTGTTTTGttttgttatttaaaataggaacagtgtctcactgtgttgcccaggctggtcttaaactcctggcctcaagcgatcctccttccttggcctcccaaagtgctgggattacaggtgtgagccaccaaagccggccCCACCTTGCtttttaaaacagctctgttgaggtgtaactgacaggtaatgaactgcacataCGTGAAGTGACCGATGCATTTGCCTGTGAAGCTGTCGCCagaacatgtccatcaccaccaacagcagtttcacaccccggtctaaaccgtccctcgtgtcctccatgttcaggcaaccactggtctgctccctctcactaaaggttaatttatatattctagaattttatctgagtggaatcgcagagcaagtactgtggggggaggtgcttctactcagcataattattttggcattcacccattttgtgtacatcaataatccacattttgtattgcatggatataccacagtttatttatttacctgttgaccgatatttcgattatttccaatttctaaataaaaataaagcaaataaagctgccgtgaacattta

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