Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FERMT3P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:22278137-22278291  UCSC
Coordinates (T2T) chr17:22939789-22939943  UCSC
Coordinates (hg19) chr17:21804743-21804897  UCSC
Strand -
Parental Sequence NM_178443.3
Parental seq. overlap 132 bp
Parental seq. overlap (%) 5.2%
Genomic Region Intergenic
Retrocopy Summary FERMT3P1, located on chr17:22278137-22278291, is a retrocopy of the parental gene FERMT3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FERMT3
Full Name FERM domain containing kindlin 3
Also known as KIND3|MIG-2|MIG2B|UNC112C|URP2|URP2SF
Coordinate chr11:64205920-64223891
Strand +
Gene summary Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla FERMT3P1
Gibbon Nomascus leucogenys FERMT3P2
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FERMT3P1
AAAGTTCAAGGCCAAGCAGCTCATCCCACGGATCCTGGAAGCCCCTAGAATGTGGCTTGGCTCTTGCCGACCAGGCCCAGCTGTGCCTCCATCAGGCCTGGCAATGCTTGCCTGACTTTGGCATCTACTACCTCATGGTCAGGCTCAAGAGCAGA
>NM_178443.3
AGGAAGCTCCAAAGAGAAAGGAGGGCAGGAAGCCCACGGCCCACAGGGGTGTAGCCCGAGACCCACCTGCAGCCCCCAGCCCTTGCCAGGAAAGCAGCAGCCGCAGCCATGGCGGGGATGAAGACAGCCTCCGGGGACTACATCGACTCGTCATGGGAGCTGCGGGTGTTTGTGGGAGAGGAGGACCCAGAGGCCGAGTCGGTCACCCTGCGGGTCACTGGGGAGTCGCACATCGGCGGGGTGCTCCTGAAGATTGTGGAGCAGATCAATCGCAAGCAGGACTGGTCAGACCATGCTATTTGGTGGGAACAGAAGAGGCAGTGGCTGCTGCAGACCCACTGGACACTGGACAAGTACGGGATCCTGGCCGACGCACGCCTCTTCTTTGGGCCCCAGCACCGGCCCGTCATCCTTCGGTTGCCCAACCGCCGCGCACTGCGCCTCCGTGCCAGCTTCTCCCAGCCCCTCTTCCAGGCTGTGGCTGCCATCTGCCGCCTCCTCAGCATCCGGCACCCCGAGGAGCTGTCCCTGCTCCGGGCTCCTGagaagaaggagaagaagaagaaagagaaggagccagaggaagaGCTCTATGACTTGAGCAAGGTTGTCTTggctggggGCGTGGCACCTGCACTGTTCCGGGGGATGCCAGCTCACTTCTCGGACAGCGCCCAGACTGAGGCCTGCTACCACATGCTGAGCCGGCCCCAGCCGCCACCCGACCCCCTCCTGCTCCAGCGTCTGCCACGGCCCAGCTCCCTGTCAGACAAGACCCAGCTCCACAGCAGGTGGCTGGACTCGTCGCGGTGTCTCATGCAGCAGGGCATCAAGGCCGGGGACGCACTCTGGCTGCGCTTCAAGTACTACAGCTTCTTCGATTTGGATCCCAAGACAGACCCCGTGCGGCTGACACAGCTGTATGAGCAGGCCCGGTGGGACCTGCTGCTGGAGGAGATTGACTGCACCGAGGAGGAGATGATGGTGTTTGCCGCCCTGCAGTACCACATCAACAAGCTGTCCCAGAGCGGGGAGGTGGGGGAGCCGGCTGGCACAGACCCAGGGCTGGACGACCTGGATGTGGCCCTGAGCAACCTGGAGGTGAAGCTGGAGGGGTCGGCGCCCACAGATGTGCTGGACAGCCTCACCACCATCCCAGAGCTCAAGGACCATCTCCGAATCTTTCGCATCCCACGAAGGCCCCGGAAGCTGACCCTGAAGGGCTACCGCCAACACTGGGTGGTGTTCAAGGAGACCACACTGTCCTACTACAAGAGCCAGGACGAGGCCCCTGGGGACCCCATTCAGCAGCTCAACCTCAAGGGCTGTGAGGTGGTTCCCGATGTTAACGTCTCCGGCCAGAAGTTCTGCATTAAACTCCTAGTGCCCTCCCCTGAGGGCATGAGTGAGATCTACCTGCGGTGCCAGGATGAGCAGCAGTATGCCCGCTGGATGGCTGGCTGCCGCCTGGCCTCCAAAGGCCGCACCATGGCCGACAGCAGCTACACCAGCGAGGTGCAGGCCATCCTGGCCTTCCTCAGCCTGCAGCGCACGGGCAGTGGGGGCCCGGGCAACCACCCCCACGGCCCTGATGCCTCTGCCGAGGGCCTCAACCCCTACGGCCTCGTTGCCCCCCGTTTCCAGCGAAAGTTCAAGGCCAAGCAGCTCACCCCACGGATCCTGGAAGCCCACCAGAATGTGGCCCAGTTGTCGCTGGCAGAGGCCCAGCTGCGCTTCATCCAGGCCTGGCAGTCCCTGCCCGACTTCGGCATCTCCTATGTCATGGTCAGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGATGAAACATGGTTTCAAACGAGTTCTTTCTTGTTACTTTTTAAAATTTCTTTTTTATAAATTAATATTTTATTGTTGGATCCTC

Publications

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