Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GDI2P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:72274550-72275148  UCSC
Coordinates (T2T) chr1:72153484-72154082  UCSC
Coordinates (hg19) chr1:72740233-72740831  UCSC
Strand +
Parental Sequence NM_001494.4
Parental seq. overlap 537 bp
Parental seq. overlap (%) 23.4%
Genomic Region Intragenic (NEGR1)
Retrocopy Summary GDI2P2, located on chr1:72274550-72275148, is a retrocopy of the parental gene GDI2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GDI2
Full Name GDP dissociation inhibitor 2
Also known as HEL-S-46e|RABGDIB
Coordinate chr10:5765222-5813434
Strand -
Gene summary GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GDI2P1
Bonobo Pan paniscus GDI2P1
Gorilla Gorilla gorilla GDI2P1
Orangutan Pongo abelii GDI2P1
Gibbon Nomascus leucogenys GDI2P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GDI2P2
CAATTAAACTTTACAGTGAGTCTTTGGCAAGATATGGCGAAAGCCCATACCTTTAACCACTCTATGGCCTTGGAGAACTGCCCCAAGGATTTGCAAGGCTAAGTGCTATTTATGGAGGTACCTATATGCTGAAAAAACCCATTGAAGAAATCATTGTGCAGAATGGAAAAGTAATTGGAGTAAAATCGGAAGGAGAAATTGCTTGCTGTAAGCAGTTCATCTGTGACCCCAGCTGTGTAAAAGATCGGGTAGAAAAAGTGGGCCAGGTGATCAGAGTTATTTGCATCCTCAGCCACCCCATCAAGAACACCAATGATGCCAACTCCTGCCAGATCATTATTCCACAGAACCAAGTCAATCGAAAGTCAGATATCTACGTCTGCATGATCTCCTTTGCGCACGATGTAGCAGCACAAGGGAAGTACATTGCCATAGTTAGTACGACTGTGGAAACCAAGGAGCCTGAGAAGGAAATCAGACCAGCTTTGGAGCTCTTGGAACCAACTGAGCAGAAATTTGTTAGCACCAGTGACaTTTCCCGCACGTACGATGCCACC
>NM_001494.4
AGTTCTTCTCTTCCCGTCTGAGGTGGCGGTCGGTCTCGCCTTGTCGCCAGCTCCATTTTCCTCTCTTTCTCTTCCCCTTTCCTTCGCGCCCAAGAGCGCCTCCCAGCCTCGTAGGGTGGTCACGGAGCCCCTGCGCCTTTTCCTTGCTCGGGTCCTGCGTCCGCGCCTGCCCCGCCATGAATGAGGAGTACGACGTGATCGTGCTGGGCACCGGCCTGACGGAATGTATCCTGTCAGGTATAATGTCAGTGAATGGCAAGAAAGTTCTTCATATGGATCGAAACCCTTACTACGGAGGAGAGAGTGCATCTATAACACCATTGGAAGATTTATACAAAAGATTTAAAATACCAGGATCACCACCCGAGTCAATGGGGAGAGGAAGAGACTGGAATGTTGACTTGATTCCCAAGTTCCTTATGGCTAATGGTCAGCTGGTTAAGATGCTGCTTTATACAGAGGTAACTCGCTATCTGGATTTTAAAGTGACTGAAGGGAGCTTTGTCTATAAGGGTGGAAAAATCTACAAGGTTCCTTCCACTGAAGCAGAAGCCCTGGCATCTAGCCTAATGGGATTGTTTGAAAAACGTCGCTTCAGGAAATTCCTAGTGTATGTTGCCAACTTCGATGAAAAAGATCCAAGAACTTTTGAAGGCATTGATCCTAAGAAGACCACAATGCGAGATGTGTATAAGAAATTTGATTTGGGTCAAGACGTTATAGATTTTACTGGTCATGCTCTTGCACTTTACAGAACTGATGATTACTTAGATCAACCGTGTTATGAAACCATTAATAGAATTAAACTTTACAGTGAATCTTTGGCAAGATATGGCAAAAGCCCATACCTTTATCCACTCTATGGCCTTGGAGAACTGCCCCAAGGATTTGCAAGGCTAAGTGCTATTTATGGAGGTACCTATATGCTGAATAAACCCATTGAAGAAATCATTGTACAGAATGGAAAAGTAATTGGTGTAAAATCTGAAGGAGAAattgctcgctgtaAGCAGCTCATCTGTGACCCCAGCTACGTAAAAGATCGGGTAGAAAAAGTGGGCCAGGTGATCAGAGTTATTTGCATCCTCAGCCACCCCATCAAGAACACCAATGATGCCAACTCCTGCCAGATCATTATTCCACAGAACCAAGTCAATCGAAAGTCAGATATCTACGTCTGCATGATCTCCTTTGCGCACAATGTAGCAGCACAAGGGAAGTACATTGCTATAGTTAGTACAACTGTGGAAACCAAGGAGCCTGAGAAGGAAATCAGACCAGCTTTGGAGCTCTTGGAACCAATTGAACAGAAATTTGTTAGCATCAGTGACCTCCTGGTACCAAAAGACTTGGGAACAGAAAGCCAGATCTTTATTTCCCGCACATATGATGCCACCACTCATTTTGAGACAACGTGTGATGACATTAAAAACATCTATAAGAGGATGACAGGATCAGAGTTTGACTTTGAGGAAATGAAGCGCAAGAAGAATGACATCTATGGGGAAGACTAACAGCAGTACATGTTATTATGTAATTAGGACACATTTAAAATTTGGCAAATAATGCATATAATGAAATCAATATTGTAAGGCCTGCTTTTGTAATGAAAATGGAGAGAATGAAGAGCGCTGTGCCAGTAAATACTCCCCTTCACCTTTCTAATTATTAACTTGTTTTCATGGAGTGGCTATTCAGCATTGGCAGTTACCACATTCTGTTCAATTTAACCAAACTGGCTTTTTTTTTTTCTAGTGAAGTTAAACAAACATTGGGATACCGACACAGACAACTTGAGACAGTTTTTTTAATCTTTTAATCAGTGTAGCTATGTGCTGCTGCTGCTCAAGAGCTGGATCCATACAGGTTGTGTGTCATCTGTCCTCTTGAGGTTCAGGAGATTCTAAATTGAATATTCCACGGTTTGGGACAGCATCCGGAAGTTTTCCCTATGACTTTATATTTTGTATTATGTCAAATGTTATGGCAGGGCCCAAATAGCATAGCCACAAGTTTGGTTTATGTGGGCATAAAATTCTAACCAAACCCCAGACATAGGGAGTCATTTGGAGAAAGCCTGTATGTGGTGTTTTAACCTAATAAAGTTGATGAGAGAGAAGGGGAGAGGAAGCGAACATAAAGCGGGTCAAGTGTAGTGCATCTTTTGTATCTCAGGCGTGGCTTCTTCAGTGGACCAAGCTGCAATGCAGTATTGACTTGACAGAGCCTCTACTTCTGTCTCAAAATGGCTCCAAATGATTTCTGTACTGCAAAATAAAGCCAAATTCTGGAAACTA

Publications

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