Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name NME4P3
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:29972665-29973024  UCSC
Coordinates (T2T) chr17:30915999-30916358  UCSC
Coordinates (hg19) chr17:28299683-28300042  UCSC
Strand +
Parental Sequence NM_001286439.2
Parental seq. overlap 298 bp
Parental seq. overlap (%) 25%
Genomic Region Intragenic (EFCAB5)
Retrocopy Summary NME4P3, located on chr17:29972665-29973024, is a retrocopy of the parental gene NME4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NME4
Full Name NME/NM23 nucleoside diphosphate kinase 4
Also known as NDPK-D|NM23H4|nm23-H4
Coordinate chr16:396729-400754
Strand +
Gene summary The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LOC112204144P3
Bonobo Pan paniscus NME4P3
Orangutan Pongo abelii NME4P2
Gibbon Nomascus leucogenys NME4P1
Rhesus Macaca mulatta NME4P2
Golden snub-nosed monkey Rhinopithecus roxellana NME4P1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NME4P3
AGGGATGTGATCCAGCGCTTTGGAGGCAGGGCTTCAAGCTGGTAGGGATGAAGATCCTGTGGCCGGCCAGAAAGCGTCCTTGCTGAACACTACCAGGACCTGCGAAGGAAGCCCCTCTACCCAGCCCTCCTTAGCTATGTGAGCTCCAGGCCTGTTGATGGCCATGGTCTGGGAAGGGTACAATGTGATCCATGCCTCGAGGGCCATGATAGATACCCTGACAGGGTTGAGGCTGACTCTGTGACCATATGGGGAGACTTCAGCGACGTCCACATCAGCAGGAACATCATTCACACCAGCTATTCAGGGTAGGGGGTCAGAAAGAGATCCAGCTGTGGTTTGAAAGCAGTGAGCTGGTGA
>NM_001286439.2
ACAGCGGCCCGCGGGCCGGGCGTCATGGGCGGCCTCTTCTGGCGCTCCGCGCTGCGGGGGCTGCGCTGCGGCCCGCGGGCCCCGGGCCCGAGCCTGCTAGTGCGCCACGGCTCGGCGTCCCCTCCAGAGGAGGACGGCTGGGGCGGAGCTCAGCGCTGACCCTGGGTCTGGAAGCGACAGGCCTTGAAACTCCACAGCAGCACAGGCCCCGTCTCCTGGCTCGGACAGAACCCTGCTACCTTCCCTCTTCAATCTTCAGGCCCCTTTTTGTCCGTGTTTCCAGGGCTCACCTGGTGGGGAAAGAGGGCCCTCCTGGACCCGGGAGCGGACCCTGGTGGCGGTGAAGCCCGATGGCGTGCAACGGCGGCTCGTTGGGGACGTGATCCAGCGCTTTGAGAGGCGGGGCTTCACGCTGGTGGGGATGAAGATGCTGCAGGCACCAGAGAGCGTCCTTGCCGAGCACTACCAGGACCTGCGGAGGAAGCCCTTCTACCCTGCCCTCATCCGCTACATGAGCTCTGGGCCTGTGGTGGCCATGGTCTGGGAAGGGTACAATGTCGTCCGCGCCTCGAGGGCCATGATTGGACACACCGACTCGGCTGAGGCTGCCCCAGGAACCATAAGGGGTGACTTCAGCGTCCACATCAGCAGGAATGTCATCCACGCCAGCGACTCCGTGGAGGGGGCCCAGCGGGAGATCCAGCTGTGGTTCCAGAGCAGTGAGCTGGTGAGCTGGGCAGACGGGGGCCAGCACAGCAGCATCCACCCAGCCTGAGGCTCAAGCTGCCCTTACCACCCCATCCCCCACGCAGGACCAACTACCTCCGTCAGCAAGAACCCAAGCCCACATCCAAACCTGCCTGTCCCAAACCACTTACTTCCCTGTTCACCTCTGCCCCACCCCAGCCCAGAGGAGTTTGAGCCACCAACTTCAGTGCCTTTCTGTACCCCAAGCCAGCACAAGATTGGACCAATCCTTTTTGCACCAAAGTGCCGGACAACCTTTGTGGTGGGGGGGGGTCTTCACATTATCATAACCTCTCCTCTAAAGGGGAGGCATTAAAATTCACTGTGCCCAGCACATGGGTGGTACACTAATTATGACTTCCCCCAGCTCTGAGGTAGAAATGACGCCTTTATGCAAGTTGTAAGGAGTTGAACAGTAAAGAGGAAGTTTTGCACACCCA

Publications

PMID - Link Title