Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYT1LP1
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Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:31709569-31709718  UCSC
Coordinates (T2T) chr17:32655386-32655535  UCSC
Coordinates (hg19) chr17:30036588-30036737  UCSC
Strand +
Parental Sequence XM_017003608.1
Parental seq. overlap 137 bp
Parental seq. overlap (%) 2.9%
Genomic Region Intergenic
Retrocopy Summary MYT1LP1, located on chr17:31709569-31709718, is a retrocopy of the parental gene MYT1L. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYT1L
Full Name myelin transcription factor 1 like
Also known as MRD39|NZF1|ZC2H2C2|ZC2HC4B|myT1-L
Coordinate chr2:1789113-2331388
Strand -
Gene summary This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]

Homology

Species Scientific Name Retrocopy
Rhesus Macaca mulatta LOC114675510P1
Baboon Papio anubis MYT1LP1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.20.3
log10(TPM+1)

Related Sequence

>MYT1LP1
CAAAGTGGTATCAGGATAGCACAGAGCAAAGAAGATAAAGAAACTCAAGAGCCCATCAGGTGTCCCGCCCCCAGGTGCGACGGCCAGGGCCACATCACCGGGTAGTACGCGTCCCACTGTAGCGCCTCCGGGTGCCCCTTGGCAGCCAAG
>XM_017003608.1
GCGTGTGCATGGGGGTGTGTGGAAGTCAAACAGATCCCTGAGGCCTGCGAGCCTATCGCGCTGCATTTGTCATTCCTGCCCGGGCGACATTTTTTTTTTCCCTAAGCTACTGCACACTAAACAGTGAGAGAGCTTTTCCCTGCAGTCTTGTTGAAGCACCCCGGGTTTTTTGCTCATTGTTGGTGGGTGCATTTTAATTTTTTCATTCCCTGGACTATGGGTTATGATATCCATACTCACTGAAGACAAAAAGCCACCTTTTCTGCGTCTTGGTGGCATGCATGTGTCTCATCATCCTTTCAAACTTGTGGTGGAACAGGGTTTTCTTCCCTGTCTGTGTATTTTGAGCCAGCACAGTTACCAAAATTGAACTTGTCTTTCGCTTGTGAGCGGTTGTGGTCATTGTGAGGGCGGGTCATGAGGAGGCTGTAGCCAAGGACGAGGTGTGTGCGGCTGTTGCCTGGACGTTTGTCCAATCCACGTTGACATTTGAGGGATCACAGCGTGTGAAAATGAACTCAGAGGAGAATTGGTGAATTCCTATCCAGTGGGCATCTTCAAACCCTGGTCGACGGCGGAAGAATATCAGGTCCTGAGATCACCCACCCGGCGCGGCAACAGTGCAGAGTGGCCACATCTGGTGGAAGAAGAAAAAAATGTAGTTATTGAATTCAATCAAGTGTTTGCATCTTTCAAGCTATCAACAAAATTCCATCAAGAAAGGTTCCAGTTGGTCTCACAGACGTATGGATATCCGAGGAGCCACCTAAAGatggagaaatcaaggcatagagagattaagtgactttgccacagtcacaagctggagaggaccaggagtagagcttagagcgagcccctgactctgggcctgcgtcctgccaggagtcacgctgcctcCGTTCCTAGGAGAGAAGACTTCCTGTAAGATGGAGGTGGACACCGAGGAGAAGCGGCATCGCACGCGGTCCAAAGGGGTTCGAGTTCCCGTGGAACCAGCCATACAAGAGCTGTTCAGCTGTCCCACCCCTGGCTGTGACGGCAGTGGTCATGTCAGTGGCAAATATGCAAGACACAGAAGTGTATATGGTTGTCCCTTGGCGAAAAAAAGAAAAACACAAGATAAACAGCCCCAGGAACCTGCTCCTAAACGAAAGCCATTTGCCGTGAAAGCAGACAGCTCCTCAGTGGATGAGTGTGACGACAGTGATGGGACTgaggacatggatgagaaggaggaggatgagggggaggagtactccgaggacaatgatgagccaggggatgaggacgaggaggacgaggagggggaccgggaggaggaggaggagatcgaggaggaggatgaggacgatgacgaggatggagaagatgtggaggatgaagaagaggaagaggaggaggaggaggaggaggaagaggaagaagaAAACGAAGACCATCAAATGAATTGTCACAATACTCGAATAATGCAAGACACAGAAAAGGATGATAACAATAATGACGAATATGACAATTACGATGAACTGGTGGCCAAGTCATTGTTAAACCTCGGCAAAATCGCTGAGGATGCAGCCTACCGGGCCAGGACTGAGTCAGAAATGAACAGCAATACCTCCAATAGTCTGGAAGACGATAGTGACAAAAACGAAAACCTGGGTCGGAAAAGTGAGTTGAGTTTAGACTTAGACAGTGATGTTGTTAGAGAAACAGTGGACTCCCTTAAACTATTAGCCCAAGGACACGGTGTTGTGCTCTCAGAAAACATGAATGACAGAAATTATGCAGACAGCATGTCGCAGCAAGACAGTAGAAATATGAATTACGTCATGTTGGGGAAGCCCATGAACAACGGACTCATGGAAAAGATGGTGGAGGAGAGCGATGAGGAGGTGTGTCTGAGCAGTCTGGAGTGTTTGAGGAATCAGTGCTTCGACCTGGCCAGGAAGCTCAGTGAGACCAACCCGCAGGAGAGGAATCCGCAGCAGAACATGAACATCCGTCAGCATGTCCGGCCAGAAGAGGACTTCCCCGGAAGGACGCCGGACAGAAACTACTCGGACATGCTGAACCTCATGCGGCTGGAGGAGCAGTTGAGCCCCCGGTCGAGAGTGTTTGCCAGCTGTGCGAAGGAGGATGGGTGTCATGAGCGGGACGACGATACCACCTCTGTGAACTCGGACAGGTCTGAAGAGGTGTTCGACATGACCAAGGGGAACCTGACCCTGCTGGAGAAAGCCATCGCTTTGGAAACGGAAAGAGCAAAGGCCATGAGGGAGAAGATGGCCATGGAAGCTGGGAGGAGGGACAATATGAGGTCATATGAGGACCAGTCTCCGAGACAACTTCCCGGGGAGGACAGAAAGCCTAAATCCAGTGACAGCCATGTCAAAAAGCCATACTATGGTAAAGATCCCTCAAGAACAGAAAAGAAAGAGAGCAAGTGTCCAACCCCCGGGTGTGATGGAACCGGCCACGTAACTGGGCTGTACCCACATCACCGCAGCCTGTCCGGATGCCCGCACAAAGATAGGGTCCCTCCAGAAATCCTTGCCATGCATGAAAGTGTCCTCAAGTGCCCCACTCCGGGCTGCACGGGGCGCGGGCATGTCAACAGCAACAGGAACTCCCACCGAAGCCTCTCCGGATGCCCGATCGCTGCAGCAGAGAAACTGGCCAAGGCACAGGAAAAGCACCAGAGCTGCGACGTGTCCAAGTCCAGCCAGGCCTCGGACCGCGTGCTCAGGCCAATGTGCTTTGTGAAGCAGCTGGAGATTCCTCAGTATGGCTACAGAAACAATGTCCCCACAACTACGCCGCGTTCCAACCTGGCCAAGGAGCTCGAGAAATATTCCAAGACCTCGTTTGAATACAACAGTTACGACAACCATACTTATGGCAAGCGAGCCATAGCTCCCAAGGTGCAAACCAGGGATATATCCCCCAAAGGATATGATGATGCGAAGCGGTACTGCAAGGACCCcagccccagcagcagcagcaccagcagctacgcgcccagcagcagcagcaacctgagctgcggcgggggcagcagcgccagcagcacgtgcagcaagagcagcTTCGACTACACGCACGACATGGAGGCGGCCCACATGGCGGCCACCGCCATCCTCAACCTGTCCACGCGCTGCCGCGAGATGCCGCAGAACCTGAGCACCAAGCCGCAGGACCTGTGCGCCACGCGGAACCCTGACATGGAGGTGGATGAGAACGGGACCCTGGACCTCAGCATGAACAAGCAGAGGCCGCGGGACAGCTGCTGCCCCATCCTGACCCCTCTGGAGCCCATGTCCCCCCAGCAGCAGGCAGTGATGAACAACCGGTGTTTCCAGCTGGGCGAGGGCGACTGCTGGGACTTGCCCGTAGACTACACCAAAATGAAACCCCGGAGGATAGACGAGGACGAGTCCAAAGACATTACTCCAGAAGACTTGGACCCATTCCAGGAGGCTCTAGAAGAAAGACGGTATCCCGGGGAGGTGACCATCCCAAGTCCCAAACCCAAGTACCCTCAGTGCAAGGAGAGCAAAAAGGACTTAATAACATGTCCAACTCCAGGGTGTGATGGGAGTGGTCATGTGACTGGTAATTACGCCTCACACAGAAGTCTGTCTGGCTGCCCCCTGGCGGACAAAAGCATTCGAAGTATGCTGGCCACCAGCTCCCAAGAACTCAAGTGCCCCACGCCTGGCTGTGATGGTTCTGGACATATCACCGGCAATTATGCTTCTCATCGGAGCCTTTCAGGTTGCCCAAGAGCAAAGAAAAGTGGTATCAGGATAGCACAGAGCAAAGAAGATAAAGAAGATCAAGAACCCATCAGGTGTCCGGTCCCCGGGTGCGACGGCCAGGGCCACATCACTGGGAAGTACGCGTCCCATCGCAGCGCCTCCGGGTGCCCCTTGGCGGCCAAGAGGCAGAAAGACGGGTACCTGAATGGCTCCCAGTTCTCCTGGAAGTCGGTCAAGACGGAAGGCATGTCCTGCCCCACGCCAGGATGCGACGGCTCAGGCCACGTCAGCGGCAGCTTCCTCACACACCGCAGatatggtattttcaacttaagatggctttatggggatgctgaccccatggtatgtggaggagtacctgTATCCATCCCCATGGTATGTGGAGGAGCACCTGTATCCATCCCCGTGGTATATGGAGGAGCACCTGTATCCATCCCCGTGGTATGTGGAGGAGCACCTGTATCCATCCCCGTGGTATGTGGAGGAGTACCTGTATCCATCCCCGTGGTATGTGGAGGAGTACCTGTATCCATCCCCGTGTTATGTGGAGGAGTACCTGTATCCATCCCCGTGGTATGTGGAGAAGTACCTGTATCCATCCCCATGGTATGTGGAGGAGTACCTGTATCCATCTCCGTGGTATGTGGAGGAGTACCTGTATCCATCCCCGTGGTATGTGGAGGAGTACCTGTATCCATCCCCGTGGTATGTGGAGGAGTACCtgtattcacactgttgtggaactgatctctccaattcttccgtctccattgaaacactgtctccattcaacactgactcgcccttcctcagctgcctagcccctggcacccacactgtgctttctgcctctgtgaatctgatgcttctagggacctcctataagtagaatcccatggggtttgcttttttg

Publications

PMID - Link Title
No publications available for this retrocopy