Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SLBPP2
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:4200521-4200705  UCSC
Coordinates (T2T) chr17:4089775-4089959  UCSC
Coordinates (hg19) chr17:4103816-4104000  UCSC
Strand -
Parental Sequence NM_001306074.2
Parental seq. overlap 156 bp
Parental seq. overlap (%) 9.1%
Genomic Region Intragenic (ANKFY1)
Retrocopy Summary SLBPP2, located on chr17:4200521-4200705, is a retrocopy of the parental gene SLBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SLBP
Full Name stem-loop binding protein
Also known as HBP
Coordinate chr4:1692731-1712319
Strand -
Gene summary This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SLBPP2
Bonobo Pan paniscus SLBPP2
Gorilla Gorilla gorilla SLBPP2
Orangutan Pongo abelii SLBPP2
Gibbon Nomascus leucogenys SLBPP1
Marmoset Callithrix jacchus SLBPP1
Mouse lemur Microcebus murinus SLBPP1
Horse Equus caballus SLBPP1
Velvety free-tailed bat Molossus molossus SLBPP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SLBPP2
ATTAAAGAAGTTCCAAGGCAGCTTCAACAATCTAGCATTCATCGCAAGGTCACCCACACATTTAAGGAGTATAGTCAACTCTCATGGGACCAGCAAATCAAACTCTAGGACGTTGTTCTGCATGCTGGGGATCATCCAGCTGAAGAAGGATGTGATTTGCAAGAAATTCATCCTGTAGACCTTGG
>NM_001306074.2
AGAGCTCGTGAGCGCCGGCGCGGGGACGCGGGTTTCTGCCTCAGgccctgccctgctctactctgcgctctctgcccgcgccgccgccgcctcagcctcggccctgcgctgcgcgcccggcccgtgctgccatggcctgccGCCCGCGAAGCCCGCCGAGGCATCAGAGCCGCTGCGACGGTGACGCCAGCCCGCCGTCCCCCGCGCGATGGAGCCTGGGACGGAAGCGCAGAGCCGACGGCAGGCGCTGGAGGCCCGAAGACGCCGAGGAGGCAGAGCACCGCGGCGCCGAGCGCAGACCCGAGAGATATAAAAGGAAACTCCTCATCAATGACTTTGGAAGAGAGAGAAAATCATCATCAGGAAGTTCTGATTCAAAGGAGTCTATGTCTACTGTGCCGGCTGACTTTGAGACAGATGAAAGTGTCCTAATGAGGAGACAGAAGCAGATCAACTATGGGAAGAACACAATTGCCTACGATCGTTATATTAAAGAAGTCCCAAGACACCTTCGACAACCTGGCATTCATCCCAAGACCCCTAATAAATTTAAGAAGTATAGTCGACGTTCATGGGACCAGCAAATCAAACTCTGGAAGGTGGCTCTGCATTTTTGGGATCCTCCAGCGGAAGAAGGATGTGATTTGCAAGAAATACACCCTGTAGACCTTGAATCTGCAGAAAGCAGCTCCGAGCCCCAGACCAGCTCTCAGGATGACTTTGATGTGTACTCTGGCACACCCACCAAGGTGAGACACATGGACAGTCAAGTGGAGGATGAGTTTGATTTGGAAGCTTGTTTAACTGAACCCTTGAGAGACTTCTCAGCCATGAGCTAACTGCCCCCTGGCGGCCAGGAAGAGAAACAGCTCCTCCCCGACTAGGTGGAAGGCTGGCCAGGCACCAAGCATGTGTGTGCACTTGTACCTGGTGGTTTCTCTGTTAGCAGTCCATTAGCTCATGCTGAATTATTTTTGCCTTACTTTCTTAAGAAACATTAATTTTATGTATAGTGAGTATATTTTGCATGTTTTAAATTGTAAATGGAGCTAAGTCCAAGAAAGTACTTGAAGCTCTCTTCCAGCGAGCTTAATTGCGTAATCCCTGTTGTCCTCCAGGGTAAGCTGACACGTCTACATAACTGGTTTTCCACAGGCATCTTCAGTTATTGCTTGTCAGGTGGACTGTTTTGGATTTAACCATGTAATCCATGGGACCAATTGAGAGTCAGCTACTTTTATAGGCATCAAAGTATTCTCAGACACCTTTAATATCTTTATGGAAACTTAATTTTTGGCCTTTTATCAATATGTCATAACAGCATTCTGAAGTCAGACATTGTTAAATTGAGCTATTAAACTAATGAGTTTTATGTAAGTTATATGGTCTTAATTTGGTACTTGTAAATAGCACTAGTTAGACTCTTTAGAATACTCCAAGAGTTAGGGCAGCAGAGTGGAGCGATTTAGAAAGAACATTTTAAAACAATCAGTTAATTTACCATGTAAAATTGCTGTAAATGATAATGTGTACAGATTTTCTGTTCAAATATTCAATTGTAAACTTCTTGTTAAGACTGTTACGTTTCTATTGCTTTTGTATGGGATATTGCAAAAATAAAAAGGAAAGAACCCTCTTTCACTGACTGGGGCTGTTGCCAGGTGGGCCAGCTGCCGTGAGAGCTGACATGTTTGGAGGGTCAGAA

Publications

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