Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name RYKP1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:4222189-4225054  UCSC
Coordinates (T2T) chr17:4111442-4114299  UCSC
Coordinates (hg19) chr17:4125484-4128349  UCSC
Strand +
Parental Sequence NM_002958.4
Parental seq. overlap 2429 bp
Parental seq. overlap (%) 78.9%
Genomic Region Intragenic (ANKFY1)
Retrocopy Summary RYKP1, located on chr17:4222189-4225054, is a retrocopy of the parental gene RYK. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RYK
Full Name receptor like tyrosine kinase
Also known as D3S3195|JTK5|JTK5A|RYK1
Coordinate chr3:134157133-134250859
Strand -
Gene summary The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RYKP1
Bonobo Pan paniscus RYKP1
Gorilla Gorilla gorilla RYKP1
Orangutan Pongo abelii RYKP1
Gibbon Nomascus leucogenys RYKP1
Green monkey Chlorocebus sabaeus RYKP1
Crab-eating macaque Macaca fascicularis RYKP1
Rhesus Macaca mulatta RYKP1
Baboon Papio anubis RYKP1
Golden snub-nosed monkey Rhinopithecus roxellana RYKP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RYKP1
GGGGCCCAGCGTGAGCCTCTACCTGAGTGAGGATGAGGTGCACCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGACAAATGACCTTATTATTCACTACGCTCTGTCCTTTAATCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATTCGAAGTCCAAGGTTGAATGTAAGCTGGGATTCCAAGCGGACAATGTTTTGGCAATGGACCTGCCCCAGGGCAACATTTCTGTTCAGGGAGAAGTTCTACGCACTTTATCAGTATTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTCAATTCTTCAAAGAATTTTACCGTCTTAAATTTTAAACCAAGGAAAATGTGCACCAAAAATGGCCCTGACACGCAGCTCCAACCACTTCTACGCGTGTTTTATATTAGGGTAGGGTTTCTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGGTTGAACTGGATGACAGCATTAGTGCCAGCAGGAGTTCCCAAGGGTTGTCTCAGCCATCCACCCAGACGACTCAGTATCCGAGAGCTGACACACCCAACAATCCAACTCCTATCACCAGCTCCTCAGGTTATCCTACCTTGCGGATAGAGAAGAACGACTTGAGAAGTGTCACTCTTTTGGAGGCCAAAGCCAAGGTGAAGGATATAGCAATATCCAGGGACAGGATAACTCTAATAAAAGATGTACTCCAAGAAGGTACTCTTGGGCATATTTTCCATGGGATTTTAATAGATAAAAAAGATCCAAATAAAGAAAAACAAGCATTGGTCGAAACAAAGATCAAGCTTCTGAAATTCAGGTGACAATGATGCTCACTGAAAGTCGTAAGCTGCAAAGTCTTCATCACAGAAATCTTCTTCCTATTACTCATGGGTGTATACGAGAAAAGCCCATGGTGACACTGCCTTACATGAACTGAGGGAATCTTCACTTGTTTTTACGGCAGTGCAAGTTAGTAGAGGCCAATAATCCACAGGCAATTTCTCAACAAGACCTGGTACACATGGCTATTCAGATTGCCTGTGGAATGAGCTACCTGGCCAGAACGGAAGTCATCCACAAAGACCTGGCTGCTAGGAACTGTATCACTGATGACACACTTCAAGTTAAGATCACAGACAATGCCGTCTCATGGACTATCACTGTCTGGGGGACAATGAAAACAGGCCAGTTTGTTGGATGGCTCTTGAAAGTCTGGTTAATAACGAGTTTTCTAGCACTAGTGATGTGTGGGGCCTTTGGAGTGATGCTGTGGGAACTCATGACTCTGGGCCAGACGCCCTACATGGACACTGACCCCTTCGAGATGGCCGCATACCTGAAAGATGGTTACCGAATAGCCCAGCCAATCAACTGTCCTGATGAACCATTTGCTGTGATGGCCTGTTGCTGGGCCTTAGATCCGGGGGAGAGGCCCAAGTTTCAGCAGCTGGTACAGTGTCTCACAGTTTCATGCAGGCCTGGGGGCCTACGTCTGACTCTTCTCTCGCAATCCCACAGCATCAGGAGAAAGGTGCCTGTCATGGATGCTTTGTATCTAACACCACGCCAACAGAAGCACATTTGTCTTCCAGAACACTGTGCCTCAGCAATGCTTTAGAATCTGAACTTTTTAAGACAGACTTAATAATGTGGCATATTTTCTAGATATCACTTTTATTAGGTTGAACTGAAAGGGTTTTTGTAAATTTTTTGGCCAAAATTTTTTAAAACATAGTTACCTTGGACTAGAGGTACATTGTTACAAAATGAACAGTTTTTAAAATTGTTCAGACACAGATATTTGGAAGTAGCTATCTTAGTGCCAACTGCTTTTTATTTTTTTTACTTCATCAAGGTGATGTAAGTGACTCACCTTTGAAGtGAAGTTTTTTTAATGTTATTTTTTATCACTACTCTTGGAAATGGCCTGTCTTCAAGATGCAATACTTTTCTTAGGAAAGGAAAAACAGCATAAAAAGATACCTGGTTTGTCTTGTACAAGAAAAGGCAATATGAGAGGAAGAAAATTTAAAGAAAAGCTAGAGGAAAAAAAATTTTTTTTAATACTTATTAGAAGCAAACTGCCCTTGCATGGAAAACTGTTTGTTTGTTTTTTTTTAGTGAAAAGGAATTCTGCTTTCGTGTTTTTGGGAAAGCAGGAACTGAGTTCATTGCATCTTTAATTTGGTGGAAATTAGCTTTTCTGTGAACCAGAAGTGGTTTGAGGCAGATCTGTAGTAAATAATGGTGATTTTATTTATTTTTACTCTCTGGAAAAGGAGACAATACAATTCCAGAAAGTGGACTCATATTTCTAAGGTTAAGATTCCCGTTTATTGCACCTAGAATAGTGCTATGCACAGAGTGGGTGCTTGAGTTGTCGTTTTTTTTTTTTTTTTAAATAAACTGGTAAATTTTGTGCTTATCTTCAAGGCTGGCTTAAGTATAAACTTGTTTTTTTAAACACTTGAAAAATTAAAGGATTTGTTTTATATT
>NM_002958.4
AGCCCCCAACTCCGGACGATGCAGCGAGGAGGCGGCGGCGGCGGCGCGCTCCGGAGGTCTGAAGCCACTGCTGGCTGCCACGGGCCGGCGGTGCGATGAGCTGGGCAGCCGCCCCCggctcggggctgtgagcggctcggggccgggggtgggcggcGGTGCGGCGGGCGGCCGACGCTCCTCTTCGGCGGCGGCGGCGGCGGCCATGCGTGGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCCTGAGGgccccgccgccgccgccgctgctgcttctgcttgcgctgttgccgctgctgcccgcgcctggcgctgccgccgcccccgccccgcggcccccgGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGTCACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAGCTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTGTTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAATTTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGCATTAGTGCCAGCAGTAGTTCCCAAGGGCTGTCTCAGCCATCCACCCAGACGACTCAGTATCTGAGAGCAGACACGCCCAACAATGCAACTCCTATCACCAGTTATCCTACCTTGCGGATAGAGAAGAACGACTTGAGAAGTGTCACTCTTTTGGAGGCCAAAGGCAAGGTGAAGGATATAGCAATATCCAGAGAGAGGATAACTCTAAAAGATGTACTCCAAGAAGGTACTTTTGGGCGTATTTTCCATGGGATTTTAATAGATGAAAAAGATCCAAATAAAGAAAAACAAGCATTTGTCAAAACAGTTAAAGATCAAGCTTCTGAAATTCAGGTGACAATGATGCTCACTGAAAGTTGTAAGCTGCGAGGTCTTCATCACAGAAATCTTCTTCCTATTACTCATGTGTGTATAGAAGAAGGAGAAAAGCCCATGGTGATATTGCCTTACATGAATTGGGGGAATCTTAAATTGTTTTTACGACAGTGCAAGTTAGTAGAGGCCAATAATCCACAGGCAATTTCTCAGCAAGACCTGGTACACATGGCTATTCAGATTGCCTGTGGAATGAGCTACCTGGCCAGAAGGGAAGTCATCCACAAAGACCTGGCTGCCAGGAACTGTGTCATTGATGACACACTTCAAGTTAAGATCACAGACAATGCCCTCTCCAGAGACTTGTTCCCCATGGACTATCACTGTCTGGGGGACAATGAAAACAGGCCAGTTCGTTGGATGGCTCTTGAAAGTCTGGTTAATAACGAGTTCTCTAGCGCTAGTGATGTGTGGGCCTTTGGAGTGACGCTGTGGGAACTCATGACTCTGGGCCAGACTCCCTACGTGGACATTGACCCCTTCGAGATGGCCGCATACCTGAAAGATGGTTACCGAATAGCCCAGCCAATCAACTGTCCTGATGAATTATTTGCTGTGATGGCCTGTTGCTGGGCCTTAGATCCAGAGGAGAGGCCCAAGTTTCAGCAGCTGGTACAGTGCCTAACAGAGTTTCATGCAGCCCTGGGGGCCTACGTCTGACTCCTCTCCAATCCCACACCATCAGGAAGAAGGTGCCTGTCGGGGCTCACTTGAAGCCTGTCAGGGATGCTTTGTATCTAACACAACGCCAACAGAAGCACATTTGTCTTCCAGAACACCGTGCCTTAGAAATGCTTTAGAATCTGAACTTTTTAAGACAGACTTAATAATGTGGCATATTTTCTAGATATCACTTTTATTAGGTTGAACTGAAAGGGTTTTTGTAAATTTTTTGGCCAAAATTTTTTAAAACATACTTACTTTGGACTAGGGGTACATTCTTACAAAATAAATAAACAGTTTTTAAAATTGTTTAGACACAGATATTTGGAATTAGCTATCTTAGTGCCAACTGCTTTTTATTTTTTTACTTCATCAAGGTGATGTAAGTGACTCACCTTTAAAGTTTTTTTAGTGTTATTTTTTATCACTACTCTGGGAAATGGTTTGTCTTCAAGATGCAATACTTTTCTTAGTAAAGGAAAAACAGCATAAAAAGATACCTGGTCTGCCTTGTACAAGAAAAGGCAATATTAGAGGAAGAAAATTTAAAGAAAAGCTAGAGGAAAAAAAAATTTTTTTAAAAATACTTATTAGAAGCAAACTGCCCTTGCATGGAAAACTGTTTATTTTTTTCAGTGAAAAGGAATTCTGCTTTCGTGTTTTTGGGAAAGCAGGAACTGAGTTCATTACATCTTTAATTTGGCAGAAATTAGCCTTTCTGTGAACCAGATGTGGTTTGGGGCAGATCTGTAGTAAACAATGGTGATTTTATTTATTTTTACTCTCTGGAAAAGGAGATAATACAATTCCAGAAAGTGAACTCATATTTCTAAGGTTAAGATTCCCTTTTATTGCACCTAGAATAGTGCTATGCACAGAGCGGGTGCTTGAGTTGTTGTCGTTTTTTGTTTGTTTTTTAAATGTAAACTGGTAAATTTTGTGCTTATCTTCAAGGCTGGCTTAAGTATAAAATTGTTTTTTAAACACTTGAAAAATTAAAGGATTTGTTTTATATTA

Publications

PMID - Link Title