Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name SHC1P2
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:44229126-44230218  UCSC
Coordinates (T2T) chr17:45082222-45083314  UCSC
Coordinates (hg19) chr17:42306494-42307586  UCSC
Strand -
Parental Sequence XM_011509897.1
Parental seq. overlap 998 bp
Parental seq. overlap (%) 32.1%
Genomic Region Intergenic
Retrocopy Summary SHC1P2, located on chr17:44229126-44230218, is a retrocopy of the parental gene SHC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SHC1
Full Name SHC adaptor protein 1
Also known as SHC|SHCA
Coordinate chr1:154962298-154974492
Strand -
Gene summary This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SHC1P1
Bonobo Pan paniscus SHC1P1
Gorilla Gorilla gorilla SHC1P1
Orangutan Pongo abelii SHC1P1
Gibbon Nomascus leucogenys SHC1P1
Green monkey Chlorocebus sabaeus SHC1P1
Crab-eating macaque Macaca fascicularis SHC1P1
Rhesus Macaca mulatta SHC1P1
Baboon Papio anubis SHC1P1
Golden snub-nosed monkey Rhinopithecus roxellana SHC1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SHC1P2
TGGAGGTCCTGCAATCAATGCGTGCCCTCGACTTCAACACCCAACTCAGGTCACGCAGGGAGGCAGGCCATCAGTCTGGTGTGTGATGCTGTGCTGGGTGTGAAGGGGGTGACAAGGAAGAGAAAGCCCTGTAGCTGCCTGCTCAGCTCTATCCTGGGAAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGGACACAGCTGAGGATGTTGCCTACGTTGCCAAAGACCCTGTGAATCAGAGAGCCTGCCACATTCTGGAGTGTCCCAAAGGCCCTCCCAGGATGTCATTAGCACCATTGGCCAGGCCTTCGAGTTGTGCTTCAAACAATACCTCACGAACCCACCCCAACTGCTCACCCCCAAGACAGGATGGCTGGCTTTGATGGATCAGCTTGGGATGAGGAGGAGGAAGAGCCACCTGACCATTAGTACTATAATGACGTCCCTGGGAAGGAACCTTCTCTTGGGGAGTTGGTAGACATGAGGCTTCGGGAAGGAGCCACTTCAGAGGCTGCTTGACCCACTCCACCCAGTGTCTGGACCCCCAGCCACTTGGGAGCTACACTGCCTGTGGGATAGCCTGCTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGCAGGCAGAGAGCTCTTCAATGATCCCTATATCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGAAGGTGGTGCTAGGCCCCCCCATCCTGCCATCAATCGCAGTGCACCCTGGGACCTCTTTGACATGAAGCCCTTTAAAGATGCTCTTTGGGTGCCTCCCCCTCCCCAGTGGTTTCCATGGCTGAGCAGCTCCAAGGGGAGCCCTGGTTCCACGGGAAGCTGAGCCAGCGAGAGGCTGAGGCATTGCTGCAGCTCCATGGCGACTTCCTGGTGCGGGAGAGCATGACCAAGGCCAGTATGTGCTTACTGGCTTGCAGAGTGGGCTGCCTAAGCACCTGCTATTGGTGGACCCTGAAGGACTGGTTTGGACAAAGGATCACTGCTTTGAGAGTGTCa
>XM_011509897.1
AACTCGGGAAAGTGGGAAGCGTGAAGGAGGGACCCTGAGGTAGAGGGTCAGGGGTTAGTGAGGCCGGAAGTGAGTGTAATAAAGTTTCTCCAGGGAGGCAGGGCCCGGGGAGAAAGTTGGAGCGGTAACCTAAGCTGGCAGTGGCGTGATCCGGCACCAAATCGGCCCGCGGTGCGGTGCGGAGACTCCATGAGGCCCTGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGGTTCGGTACATGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTGAGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGGACACAGCCGAGTATGTCGCCTATGTTGCCAAAGACCCTGTGAATCAGAGAGCCTGCCACATTCTGGAGTGTCCCGAAGGGCTTGCCCAGGATGTCATCAGCACCATTGGCCAGGCCTTCGAGTTGCGCTTCAAACAATACCTCAGGAACCCACCCAAACTGGTCACCCCTCATGACAGCCACAGCTTCACTGTCCTGTCCCTCAGGATGGCTGGCTTTGATGGCTCAGCATGGGATGAGGAGGAGGAAGAGCCACCTGACCATCAGTACTATAATGACTTCCCGGGGAAGGAACCCCCCTTGGGGGGGGTGGTAGACATGAGGCTTCGGGAAGGAGCCGCTCCAGGGGCTGCTCGACCCACTGCACCCAATGCCCAGACCCCCAGCCACTTGGGAGCTACATTGCCTGTAGGACAGCCTGTTGGGGGAGATCCAGAAGTCCGCAAACAGATGCCACCTCCACCACCCTGTCCAGCAGGCAGAGAGCTTTTTGATGATCCCTCCTATGTCAACGTCCAGAACCTAGACAAGGCCCGGCAAGCAGTGGGTGGTGCTGGGCCCCCCAATCCTGCTATCAATGGCAGTGCACCCCGGGACCTGTTTGACATGAAGCCCTTCGAAGATGCTCTTCGCGTGCCTCCACCTCCCCAGTCGGTGTCCATGGCTGAGCAGCTCCGAGGGGAGCCCTGGTTCCATGGGAAGCTGAGCCGGCGGGAGGCTGAGGCACTGCTGCAGCTCAATGGGGACTTCCTGGTACGGGAGAGCACGACCACACCTGGCCAGTATGTGCTCACTGGCTTGCAGAGTGGGCAGCCTAAGCATTTGCTACTGGTGGACCCTGAGGGTGTGGTTCGGACTAAGGATCACCGCTTTGAAAGTGTCAGTCACCTTATCAGCTACCACATGGACAATCACTTGCCCATCATCTCTGCGGGCAGCGAACTGTGTCTACAGCAACCTGTGGAGCGGAAACTGTGATCTGCCCTAGCGCTCTCTTCCAGAAGATGCCCTCCAATCCTTTCCACCCTATTCCCTAACTCTCGGGACCTCGTTTGGGAGTGTTCTGTGGGCTTGGCCTTGTGTCAGAGCTGGGAGTAGCATGGACTCTGGGTTTCATATCCAGCTGAGTGAGAGGGTTTGAGTCAAAAGCCTGGGTGAGAATCCTGCCTCTCCCCAAACATTAATCACCAAAGTATTAATGTACAGAGTGGCCCCTCACCTGGGCCTTTCCTGTGCCAACCTGATGCCCCTTCCCCAAGAAGGTGAGTGCTTGTCATGGAAAATGTCCTGTGGTGACAGGCCCAGTGGAACAGTCACCCTTCTGGGCAAGGGGGAACAAATCACACCTCTGGGCTTCAGGGTATCCCAGACCCCTCTCAACACCCGCCCCCCCCATGTTTAAACTTTGTGCCTTTGACCATCTCTTAGGTCTAATGATATTTTATGCAAACAGTTCTTGGACCCCTGAATTCAATGACAGGGATGCCAACACCTTCTTGGCTTCTGGGACCTGTGTTCTTGCTGAGCACCCTCTCCGGTTTGGGTTGGGATAACAGAGGCAGGAGTGGCAGCTGTCCCCTCTCCCTGGGGATATGCAACCCTTAGAGATTGCCCCAGAGCCCCACTCCCGGCCAGGCGGGAGATGGACCCCTCCCTTGCTCAGTGCCTCCTGGCCGGGGCCCCTCACCCCAAGGGGTCTGTATATACATTTCATAAGGCCTGCCCTCCCATGTTGCATGCCTATGTACTCTACGCCAAAGTGCAGCCCTTCCTCCTGAAGCCTCTGCCCTGCCTCCCTTTCTGGGAGGGCGGGGTGGGGGTGACTGAATTTGGGCCTCTTGTACAGTTAACTCTCCCAGGTGGATTTTGTGGAGGTGAGAAAAGGGGCATTGAGACTATAAAGCAGTAGACAATCCCCACATACCATCTGTAGAGTTGGAACTGCATTCTTTTAAAGTTTTATATGCATATATTTTAGGGCTGTAGACTTACTTTCCTATTTTCTTTTCCATTGCTTATTCTTGAGCACAAaatgataatcaattattacatttatacatcacctttttgacttttccaagcccttttacagctcttggcattttcctcgcctaggcctgtgaggtaACTGGGATCGCACCTTTTATACCAGAGACCTGAGGCAGATGAAATTTATTTCCATCTAGGACTAGAAAAACTTGGGTCTCTTACCGCGAGACTGAGAGGCAGAAGTCAGCCCGAATGCCTGTCAGTTTCATGGAGGGGAAACGCAAAACCTGCAGTTCCTGAGTACCTTCTACAGGCCCGGCCCAGCCTAGGCCCGGGGTGGCCACACCACAGCAAGCCGGCCCCCCCTCTTTTGGCCTTGTGGATAAGGGAGAGTTGACCGTTTTCATCCTGGCCTCCTTTTGCTGTTTGGATGTTTCCACGGGTCTCACTTATACCAAAGGGAAAACTCTTCATTAAAGTCCGTATTTCTTCTA

Publications

PMID - Link Title