Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DND1P2
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:46259052-46260564  UCSC
Coordinates (T2T) chr17:47121079-47122582  UCSC
Coordinates (hg19) chr17:44336418-44337930  UCSC
Strand -
Parental Sequence NM_194249.3
Parental seq. overlap 1462 bp
Parental seq. overlap (%) 91%
Genomic Region Intergenic
Retrocopy Summary DND1P2, located on chr17:46259052-46260564, is a retrocopy of the parental gene DND1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DND1
Full Name DND microRNA-mediated repression inhibitor 1
Also known as RBMS4
Coordinate chr5:140670794-140673576
Strand -
Gene summary This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DND1P2
Bonobo Pan paniscus DND1P1
Gorilla Gorilla gorilla DND1P1
Orangutan Pongo abelii DND1P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DND1P2
AAGGCGGCGCTGGAGGCGTGGGTCAGGGAGACAGGCATCGCCTGGTGCAGGTGAACGGGCAGAGGAAGTATGGCGGGCCACCCCCAGGCTGGGTGGGCAGCCCGCCGCCGGCTGGGTCAGAGGTGTTCATCGGGCGGCTGCCTCAGGAAGTGTATGAGCACCAGCTATCCTGCTGTTCCAGCGCGTGGGCCGCCTCTACGAGTTCCGCCTGATGATGACCTTCAGCGGCCTGAACCGCGGCTTCGCATATGCCCGCTGCAGCTCGCGGCGCGGCGCGCAGGCCGCCATCGCCCGCTGCACAACCACCCGCTGCGGCCGTCCTGCCCGCTGCTCGTGTGCCGCAGCACCGGGAAGTGTGAGCTGAGCGTTGACTGCCTGCCGCCGAATCTGACCCGCAccgcgctgctgcccgcgctgctgcccgcgctgcAGCCGCTGGGTCCCGGCCTGCAGGAGGCGCGGCTGCTGCCCAGCCCCGGACCTGCGCCCGGGCAGATCGCTCTGCTCAAATTCAGCTCGCACTGGACCGCTGCCATGGCCAAAAAGGCCCTGGAGGAAGGGCAGCCACACCTCTGTGGAGAGCAGGTGGCTGTGGAGTGGCTCAAGCCAGAACTGAAGCAGCGACTTCGCCAGCAGCTTGTGGGTCCCTCCTTGCGGTCCCCACAGCCAGAGGGCAGCCAGTTGGCCTTGGCAAGGGACAAGTTAGGGTCCCAAGGGGCTCGGGCTACCCTGCAGTTGCTGTGCCAACGAATGAAGCTGGGCAGCCCTGTGTTCCTCACCAAGTGTTTGGGCATAGGACCTGCTGGCTGGCACCGCTTCTGGTACCAGGTGGTGATTCCTGGGCATCCGGTGCCCTTCAGCGGCCTCATCTGGGTTGTGCTGACCCTAGATGGCCGGGATGGGCATGAGGTGGCCAAGGATGCTGTGTCTGTAGGGCTGCTGCAGGCACTCAGTGAGTCTGGGGCCAACCTCCTGTGGTCTGCTGGGGCTGAGGCAGGTAGCATGGTTAAACAGTGACTCCATTCTCTCTCCACAGGCAGCCCGAATGGGCATGCAGAGCCTGTATCAGGCCCCAACCCAGCAAACCTGGGTGGCCACTATCTGACCCCCAAAGGTGGGGAGGGGCATGGGCCCAGGCCCATCAGCCTCCCTGCTGGGACAGGGACCTATGGCACCTGGGGGCAGCTTAGGTTTGGCTTAAGTTGTGGTGAGGGGCCTTGCCCTCCCCCTCCCAGCCCAGGGTCCAACCTGACCCAGTTATCTTCCATGGCCATTCCTTATCCCACCCCCACCCGATCATACCTTCCCCCCTCTGCCACAGCTTAGCATGAATCTTCTTTATTGTCCTGATTTGTCCTCTTTGTTGGTTTTTATTTGTGGGGAAGGGCAGCTGAGCCAAAGGGGTCAGAAATTCTGCCCTTTGCCTCCACCACATGGCATTCTGGTTTTGGTTTCTGTATAGTTTTGGGTCTTTCTATGCTGGTTGTATTTATGTTAAACCCCTGGTTAGTa
>NM_194249.3
ATAAAGAGGGTACGAGGGGGCCAGCTGGAGAGCCATGCAGTCCAAGCGGGATTGTGAGCTGTGGTGTGAGAGGGTGAATCCAGAGAACAAGGCGGCGCTGGAGGCGTGGGTCAGGGAGACAGGCATCCGCCTGGTGCAGGTGAACGGGCAGAGGAAGTATGGCGGGCCACCCCCAGGCTGGGTGGGCAGCCCGCCGCCAGCTGGGTCAGAGGTGTTCATCGGGCGGCTGCCTCAGGACGTGTACGAGCACCAGCTTATCCCGCTGTTCCAGCGCGTGGGCCGCCTCTACGAGTTCCGCCTGATGATGACCTTCAGCGGCCTGAACCGCGGCTTCGCCTATGCCCGCTACAGCTCGAGGCGCGGCGCGCAGGCCGCCATCGCCACGCTGCACAACCATCCGCTGCGGCCGTCCTGCCCGCTGCTCGTGTGCCGCAGCACCGAGAAGTGTGAGCTGAGCGTTGACGGCCTGCCGCCGAATCTGACCCGCAGCGCGCTGCTGCTCGCGCTGCAGCCGCTGGGTCCCGGCTTGCAGGAGGCGCGGCTGCTGCCCAGCCCCGGACCGGCGCCCGGGCAGATCGCTCTGCTCAAATTCAGCTCGCACCGGGCCGCTGCCATGGCCAAAAAGGCCCTGGTGGAAGGGCAGTCACACCTCTGTGGAGAGCAGGTGGCTGTGGAGTGGCTCAAGCCAGACCTGAAGCAGCGACTTCGCCAGCAGCTTGTGGGTCCCTTCTTGCGGTCCCCACAGCCAGAGGGCAGCCAGTTGGCTTTGGCAAGGGACAAGTTAGGGTTCCAAGGGGCTCGGGCTACCCTGCAGTTGCTGTGCCAACGAATGAAGCTGGGCAGCCCTGTGTTCCTCACCAAGTGTTTGGGCATAGGACCTGCTGGCTGGCACCGCTTCTGGTACCAGGTGGTGATTCCTGGGCATCCGGTGCCCTTCAGCGGCCTCATCTGGGTTGTGCTGACCCTAGATGGCCGGGATGGGCATGAGGTGGCCAAGGATGCTGTGTCTGTACGGCTGCTGCAGGCACTCAGTGAGTCTGGGGCCAACCTCCTGTGGTCTGCTGGGGCTGAGGCAGGTACCATGGTTAAACAGTGACTCCATTCTTTCTCCACAGGCACCCTGAATGGGCATGCAGAGCCTGTGTCAGGCCCCATCCCAGCAGGCCTGGGTGGCCACTTTCTGACCCCCAAAGGTGGGGAGGGGCATGGGCCCAGGCCCATCAGCCTCCCTGCTGGGACAGGGACCTATGGCACCTGGGGGCAGCTTAGGTTTGGGTTAAGTTGTGGTGAGGGGCCTTGCCCTCCCGCTCCCAGCCCAGGGTCCAACCTGACCCAGTGATCTTCCATGGCCGTTCCTTGTCCCACCCCCACCCGATCATACCTTCCCCCCTCTGCCACAGCTTAGCATGAATCTTCTTTATTGTCCTGATTTGTCCTCTTTGTTGGTTTTTATTTGTGGGGAAGGGCAGCTGAGCCAAAGGGGTCAGAAATTCTGCCCTTTGCCTCCACCACATGGCATTCTGGTTTTGGTTTCTGTATAGTTTTGGGTCTTTCTATGCTGGTTGTATTTATATTAAACCCCTGGTTAGTATATA

Publications

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