Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PI4K2AP1
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Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:53434176-53435812  UCSC
Coordinates (T2T) chr17:54309350-54310986  UCSC
Coordinates (hg19) chr17:51511537-51513173  UCSC
Strand +
Parental Sequence NM_018425.3
Parental seq. overlap 972 bp
Parental seq. overlap (%) 22%
Genomic Region Intergenic
Retrocopy Summary PI4K2AP1, located on chr17:53434176-53435812, is a retrocopy of the parental gene PI4K2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PI4K2A
Full Name phosphatidylinositol 4-kinase type 2 alpha
Also known as PI4KII|PIK42A
Coordinate chr10:97640686-97676434
Strand +
Gene summary Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PI4K2AP1
Bonobo Pan paniscus PI4K2AP1
Gorilla Gorilla gorilla PI4K2AP1
Orangutan Pongo abelii PI4K2AP1
Green monkey Chlorocebus sabaeus PI4K2AP1
Crab-eating macaque Macaca fascicularis PI4K2AP1
Rhesus Macaca mulatta PI4K2AP1
Baboon Papio anubis PI4K2AP1
Golden snub-nosed monkey Rhinopithecus roxellana PI4K2AP1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.050.10.150.2
log10(TPM+1)

Related Sequence

>PI4K2AP1
TGCTCAGGCCCACCAGGAGCTGAATGAATTCCTGGAGGACCTTGAGTTCGAGGCTGCGGTGCAGCAGGCAGAACTGGCCATTAAGCACGTCATCTTTCCCAAGCCCCATCTACCAGGGCTCCAGCAGAAGCTACTTGTCAAGGACCCTCACGGGGTTCTGGAGGGTTACAATGGACTCATCCATCATTCTCTGAGTTGTGAGCCCATTGCTATTGCTTCTTTGTTGTTCAGAGGCTGGGGTTCCAGGGGAGCAGAGACAGAGAAGACTGATAACTGAGGCCTCTTGCTAGCTGCTTTGGATAAGAAAATAATTCTGAAGACTTGACAATATTAATATATGCATTTTGCTTTTTTTGCCAGTAAATAAAAGATCACTGTTGTCTTCAAATCCAACAATGAAGAGCCCCTATGGGCAACTTAATCCTAAGTGGATCAAGTGGTTGCAGAAGCTGTGCCATCCCTGCTGTTTTGGCCATGGTGCATACCTTGTCCTCAACCAGGGTTACCTCTCAGAGGCAGAGGGTGACCTGGTGGACTGAAAACTAGAATGCAACATTGTACTCCTCACAAAGGTAGTATACCTGGCCAATAAGACATTCAACTATAGAGCCATTGACAGAGTGATGTCCAGGGGCAAGCAGCTTATGCTAGAGAAAGTGTCAAAAGTTGGGCAGTGGTTTAACCCCATCAGGCAACCCACCAAAGCTTGGCTCATTCCAGCTTTTTGTTGAAGGCTATAAAGGTGCAGACTATTGGGTGTGGCGTTTTGAAGCAGAACTGCTTCCTGAGAACATTAACCAGCAACTGATCCTGCAGTTCCAGCCGCTGGTGGTGCTGGATCACATCATCTGCGACACTGACAGAGACAATGACAACTGGTAAATGTGACTGTCCAAAGGATAGCTCTAGCTTTCAGCACACAGACTGGGTGATGGTGAAGGAGCCTGTTATCAAGGTGTCTGCCATAGACAATGGGCTGGCCTTCCCACAAAAGCAGCCTGACTCCTAGAGGGAATATCCTTTGCACCGGGCCTGGTTGCCCCGGACAAAAGTCCCATTCTCTTAGGAGTTCAAAGATCTGATCCTTCCAAAGATATCCAACCCAACTTCAAGGACTTGGAAGAGGACCTATGTGAACTCTTCAGGAAAGCTCCTGaTCTGGTTTTGACAAGGACCAGTTTGATAAGCAGATTACTGTCATGCTGGGTCAGATCCTAAATCTGACTCAGGCCTTGAAAGACAAGAGTCCCCTGCACCTTGTCCAGATGCCACCTGTGGTTGTTGAGATGAGATGGCCCATTCCCACCAGCGGTTTTCTAGCGAATCCTACACACAGAG
>NM_018425.3
CGGCCGCGAGCGCAGTGGTGTGGAGCGCGCCGGGTCCCGGAGCCGGCTGTCTGAGGGATGGACGAGACGAGCCCACTAGTGTCCCCCGAGCGGGCCCAACCCCCGGACTACACCTTCCCGTCGGGCTCGGGCGCTCACTTTCCGCAGGTGCCCGGGGGCGCGGTCCGAGTGGCGGCGGCGGCCGGCTCGGGCCCCTCTCCGCCGGGCTCGCCGGGCCACGACCGCGAGCGGCAGCCACTGTTGGATCGGGCCCGGGGCGCGGCGGCCCAGGGCCAGACCCAAACCGTGGCGGCGCAGGCCCAGGCTCTGGCCGCTCAGGCCGCGGCGGCAGCCCACGCCGCTCAGGCCCACCGCGAGCGGAACGAGTTCCCGGAGGATCCTGAGTTCGAGGCGGTGGTGCGGCAGGCCGAGCTGGCCATCGAGCGCTGCATCTTTCCCGAGCGCATCTACCAGGGCTCCAGCGGAAGCTACTTCGTCAAGGACCCTCAGGGGAGGATCATTGCTGTCTTCAAACCCAAGAATGAAGAGCCCTATGGGCATCTTAATCCTAAGTGGACCAAGTGGCTGCAGAAGCTGTGCTGTCCTTGCTGCTTTGGCCGTGACTGCCTTGTCCTTAACCAGGGCTATCTCTCAGAAGCAGGGGCCAGCCTGGTGGACCAAAAACTGGAACTCAACATTGTTCCCCGTACAAAGGTAGTATACCTGGCCAGTGAGACCTTCAACTATAGTGCCATTGACCGAGTGAAGTCCAGGGGCAAGCGGCTTGCACTAGAGAAAGTGCCAAAAGTTGGACAGCGGTTTAACCGCATCGGGCTACCACCAAAGGTTGGTTCATTCCAGCTCTTTGTTGAAGGCTACAAAGATGCAGACTATTGGCTGCGGCGTTTTGAAGCAGAACCTCTTCCTGAGAACACTAACCGGCAACTACTGCTCCAGTTTGAGCGGTTGGTGGTGCTGGATTACATCATCCGCAACACTGATCGAGGCAATGACAACTGGCTGATTAAATATGACTGTCCAATGGATAGTTCTAGCTCTCGGGACACAGACTGGGTGGTGGTGAAGGAGCCTGTTATCAAGGTGGCTGCCATAGACAATGGGCTGGCCTTCCCACTGAAGCATCCTGACTCCTGGAGGGCATATCCTTTTTACTGGGCCTGGTTGCCCCAGGCGAAAGTCCCATTTTCTCAGGAGATCAAAGATCTGATCCTTCCAAAGATATCGGACCCTAACTTCGTCAAGGACTTGGAAGAGGACCTATATGAACTCTTCAAGAAAGATCCTGGTTTCGACAGGGGCCAGTTCCATAAGCAGATTGCTGTCATGCGGGGCCAGATCTTAAATCTGACCCAGGCCTTGAAAGACAACAAGAGTCCCCTGCACCTCGTCCAGATGCCACCTGTGATTGTCGAGACGGCCCGTTCCCACCAGCGGTCTTCTAGCGAGTCCTACACACAGAGCTTTCAGAGCCGGAAGCCCTTCTTTTCATGGTGGTAGCTCCAGAGGCAGGCAGAGGAAATATTGTCAGAGACTGGTGGGAGGAAGCCTGGGGAGTGGGGTGCAGGAAAAGCCAGAGAAGCCGGTGGAGAGCAGCACCTTTAAGAGCCCTCTCTCTCTGCTTGCCACCCTGCTCAGAGCTTTCCACCCACAGGGAGAAGCACAATCAGGAACAGTGAGTGCTCCTCGCCCTTCTGATGTGGGGGAGGCTGGAGCTCCATGCACGTAGTCCAGATGCCTGGGAAGGAACATCTCCCTTCCAGCATCTGCTGGTAGCAGGCTGGGACAGTCCCTTCCTTCCCTGAAACCCTGCTCTATTGCAATTCCCTATTATATTCTGCATCAGAAAAACAAACAAAACAAAAACAACTTTAAATGCTTGTAGCAGAACCCCGGGTCATCTCATGTCAGAAACCTTTAATCCAGGCCTAAATTTGCATAGACCTGACATTCAGCTGCCTTGCAGTTGCTTCCTCCCATGAGCCAAGGTGGTGTCAGAGGGCAACTGGATGACTCGCAGTACCACAGCACTGGGACAGACAGAAGCCACACCTTTCTTTTGGGTTTTTGCCAAGCCTCCTCCATCTCCCATCAGTGCTGTGGGCTGGCTGCAAGCCTCGAAACAGTTCTCCTGGAAGGGAGGTTTTTGCTTTACCCCCGCCAGCACTTCCGCACACAATCATAGAGAACCTCTCTGCTCTCTGCTGGCCTACAGCTTGTCTGTTTCTCAAGCAGAGGCAGGAAGAGCTAGTCTTAGCATTTATATTTTAATAGGAAGTTGACTCCCAGCATGTAAAAGTGATCCACGCAGCCGGAGTGTATGCCGGGAGCTAAGTGGTCTATGGGTGAACATATCCCACCTTGCTTCCTGAGTCCTTGGTCCCAATCTTCTCATTTGTTCCTCTCGTTTTAAATTTTTTCCCCCCAACTCTTTTGATGTAAGAGTTCAGTTTGTCTTCGGGAGTGGGTCTCTGCAAGGGCTCTGGGATGAGTCTTGGCTTCCAAGAGGACAGGCTATTAGGTTCTTGGACTTTTTTCTGTGCTACCGCTGCTGCTTGGTGGAAGTAACAGGACGTGGATTCTGCCTCATAAGTGGCAGTTTCCCTTTTCTCTCTGACTTGTCCTAGGCCGATTTCTCTATGGCTTCCCTGAGAAAGGTGAGGCCCAAAGGAGAGAGGCCTTCAAACTGTCCCAGGTCCTGCGCAGCTCAGTGCGTATCTTCTTGCTTCCATGTGTCTTTTCCCCTGCTGCCTCACTCCCCACCCCCACTTGCCAGGTGTTTGAGCCATTTCTACACCAAAGCAAAGTACGGCCTCAGGAGGGAGTAAAAAGGGTGCCATCTGTGTCTGGAGGGGCAGCTGTGTTCATGCCCTGTGCTACTGGACATTTCACAATTCTGGCACCTTGCGATTGGTCAGTCAACCTCAGAAAGTAACTATCTTGAAGGTTTGAAAAACAACCAAAGAAAGGGAGTGAGGACTATGGCTGCATGTCCTCTGCTTGCCCGGCTGCAGAGCAGAGATGTGCAGCCCTCTGGTCAGCTGGTCCAGGCTGGTCCCCGCCGGTCCCCTTCCAGTCCAGCCACCAAGAGTCCACTTGTCCCGGGCTTCCACCTGGCTGACAGGAAGAATTTCTGAGAGCTGGATGTGCATGCCCTGTGGACGAAGGTACAGCTCGCCTGCCTGCCCCAATCCCAGCCCCGACAATCACATGCAGCTGACTCGGACACTGGCCTTGGGAACAATGTTCGAGAGAACACTTGCCCCTTGACTGTAGGAGCCAGAAGGGGACCCAGGTGTGCATAGCTCTCTGTAGACATTTTTACCCAAACCTGTTGGTAAAGTGCCCATCTGGTGCTCAAGAGAGCCTGGGGGTCTAACAGGGAGCCCGGCTGCCTCACCTGGCCACAGCCTCCACACCAGATCTCCACATTGTCTTGATCCAGACCAGCTCTGTGATCAGAAGGAAATTGGGTCCAGTGTAGGAGAGAGCTGGTCCTGGGCCTGGCAGGCAAGAGTGTGGGCATCCTTTCCTGGCCTTTCTCCACTCTCCCTCAAGCCTGTGCTCAGGTTGCCTTGAATGTGGACTCTGGAAGAGCCAGGGGCCCAGAATGCCGGGGGAGGCTTCTGAGTGGCACTCATGGAACACCGTCCCTCTGCCAGCCATAGGCCCTGCCTCCAGTGTCAGGGAATGGAGGCTGGGCTGCGAGAGTGTTGCTGCCCCCTGTGTCATTCTTCTAATCCAATGTAGAAATTGTACGTAATGTATTTAAATCAACGCAAATGTATGAATAACAAATACAGTTCTGACCTTTTTTGTCCAGTTTCTTTGGGGGAAGGAAGACAAAGAAGGTAGGAACGGAATTTTGAGGGCAAAGAAACCTGTGTTTCCATGGAATTGCTGAGACGTGGCTCCTGGGGCTATTTCTCCCTAATAAAGGATGATCCAGGtcctcatttccaaagtcccaatgctctgaaaaccaaaagtattttcataacccatttgaaaccaaacctgacctgaacttacactgataggaagctatgggtaattatgatgtgttccttttagtgtgattctttgttgcagaaatgtcaatatattttatgacatggttccctactagggattatacagtatttgctgactacttcctaagagccaaaaataaaaaatctgaattccaaaa

Publications

PMID - Link Title
No publications available for this retrocopy